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Acta Physiologica Congress

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Acta Physiologica 2009; Volume 195, Supplement 669
The 88th Annual Meeting of The German Physiological Society
3/22/2009-3/25/2009
Giessen, Germany

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    K
    Kahlert S.- Inhibition of Na+/H+ exchangers protects hippocampal slices from oxygen-glucose-deprivation induced injury
    Kalwa H.- TRPC1 suppresses the Ca2+ permeability in heteromeric channel complexes without effects on arterial tone
    Kameritsch P.- Gap junction mediated control of endothelial vasomotor activity
    Kamkin A.- Unusual role of Kv2 channels in rat posterior cerebral small arteries
    Kampik N.B.- Localization and regulation of the anion exchanger 3 (Slc4A3) in mouse kidney
    Kandolf R.- Parvovirus B19 protein NS1 inhibits Na+/H+ exchanger
    Kann O.- Neurometabolic coupling and oxygen demands during gamma oscillations in the hippocampus
    Kantelhardt J. W.- Sunday, March 22, Hall 4Oral SessionAdaptive processes in sleep and exerciseChairpersons: M. E. Schlfke (Hagen)P. Wahl (Kln) Sleep stages modify the coupling of respiration and heartbeat
    Karl R. M.- MGluR/TRPC3-mediated synaptic Ca2+ signaling in spiny dendrites of central neurons
    Kasch J.- Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate background Ca2+ entry and muscle fatigue
    Kasseckert S. A.- The role of cellular pH and mitochondrial permeability transition pore (MPTP) in postconditioning-mediated protection against acute myocardial reperfusion injury
     - Sunday, March 22, Hall 5Oral SessionCalcium signaling and calcium storesChairpersons: Y. Abdallah (Giessen)H. Sauer (Giessen) Ca2+-induced necrosis in human astrocytes after cerebral hemorrhage
     - Tuesday, March 24, Audimax, Poster Area CPoster Session: Cardiovascular pathophysiologyModerators: B. F. Becker (Mnchen)H.-G. Zimmer (Leipzig) The role of cytosolic Ca2+-oscillations for inflammation in human cerebrovascular endothelial cells after subarachnoid hemorrhage
     - Wednesday, 25 March, Hall 3Oral SessionSarcomeric and mitochondrial function in cardiac andskeletal muscleChairpersons: K. Boengler (Essen)T. Kraft (Hannover) Protection of cardiac myocytes against reperfusion injury through inhibition of glycogen synthase kinase-3 (GSK-3) involves the mitochondrial permeability transition pore (MPTP)
    Kasseckert S.A.- Comparable parcrine effects of human progenitor cells irrespectively of the donor's age
     - Cannabinoid receptor activation protects coronary endothelium against reperfusion injury in a cellular model of ischemia and reperfusion
    Katschinski D. M.- HIF-1 affects etoposide-resistance and MDR-1 efflux activity
     - Impact of prolyl-4-hydroxylase domain (PHD) enzyme 2 on cell motility and adhesion
     - Normoxic destabilization of ATF-4 depends on proteasomal degradation
     - Enhanced hypoxia susceptibility in hippocampal slices from a mouse model of Rett Syndrome
     - Hypoxia-inducible factor-1 affects cardiac function during chronic pressure overload
     - Expression of friend of GATA (FOG)-2 in hypoxia is modulated by HIF-1
    Kebig A.- Effect of a new type of muscarinic acetylcholine receptor activator on sarcomere shortening in isolated murine cardiac myocytes
    Kelleher D.- Metabolic adaptation of tumor-initiating cells is a key factor determining angiogenesis in a sarcoma allograft model
    Kempe D.- Monday, March 23, Hall 5Oral SessionRenal transport IIChairpersons: J. Leipziger (Aarhus, DK)E. Schlatter (Mnster) Calciuria and phosphaturia in mice expressing PKB/SGK-resistant GSK
    Kempe D. S.- Monday, March 23, Audimax, Poster Area CPoster Session: Kidney IModerators: W. Neuhofer (Mnchen)W. H. Castrop (Regensburg) Renal function of PDK1 hypomorphic mice
     - Hyperaldosteronism in Klotho-deficient mice
     - Role of APC in erythrocte survival
     - SGK1-dependent regulation of intestinal peptide transport
     - Decreased susceptibility of the PDK1 hypomorphic mouse to tumor growth upon chemical cancerogenesis
    Kemper B.- Atrial natriuretic peptide antagonizes the vasopressin mediated water permeability in inner medullary collecting duct cells via proteinkinase G
    Kentrup D.- Characterization of the epithelial sodium channel delta subunit in human nasal epithelium
    Keseru B.- Sunday, March 22, Hall 3Oral SessionPulmonary pathophysiology and hypoxiaChairpersons: D. M. Katschinski (Gttingen)H. Scholz (Berlin) Deletion of the subunit of the large conductance calcium-activated potassium channel abrogates epoxyeicosatrienoic acid-induced pulmonary vasoconstriction
     - Chronic hypoxia-induced pulmonary hypertension and pulmonary vascular remodeling are linked to the downregulation of the soluble epoxide hydrolase
    Kessels C.- Impaired cardiac function in old but not in young mice after IGF1-receptor knockout
    Kessler S.- Lung epithelial Na+ channels are regulated by mechanical forces
     - The P2X7 receptor plays an important role in purinergic signaling pathways in alveolar macrophages
    Khaleghi Ghadiri M.- The effect of DC potential shifts associated with quenching thirst on neuronal network activities
    Kieckhaefer C.- Effects of smooth muscle sensitized for light radiation with 5-aminolaevulinic acid and Bay K 8644
    Kielbasa S.- Seed based systematic discovery of specific transcription factor target genes
    Kienitz M.-C.- Downregulation of GIRK subunits by RNA-interference in rat atrial myocytes reveals transcriptional coupling of Kir3.1 and Kir3.4
     - Analysis of GIRK current desensitization using FRET
     - Acetylcholine-activated GIRK current (IK(ACh)) provides a sensitive assay for autocrine production and action of extracellular adenosine in rat atrial myocytes in vitro
     - Overexpression of A1-adenosine receptors in rat atrial myocytes results in increased functional expression of Kir2 inward-rectifying K+ channels
     - A FRET-based approach for optical recording of adenosine A1 receptor activation
    Kieser S.- Characterisation of the 5-lipoxygenase pathway and leukotriene receptors in differentiating mouse embryonic stem cell derived embryoid bodies
    Kilb W.- Use dependent shifts in intracellular Cl- alter GABAergicactions in identified neurons of the immature neocortex
     - GABAergic networks in the developing cerebral cortex are activated by taurine
    Kim H.-C.- Single-cell caspase-3/7 imaging: P2X7 receptor activation triggers cell death
    Kirschner K.- Tuesday, March 24, Audimax, Poster Area EPoster Session: Neural degeneration and agingModerators: D. Bsselberg (El Paso, US),M. Diener (Giessen) Fragile X mental retardation protein (FMRP) stimulates translation of the human achaete-scute homologue-1 (hASH1) mRNA
     - The Wilms tumor suppressor WT1 regulates interleukin-10 expression in macrophagocytic cells
    Kirschning K.- Fever, sickness behavior and circulating cytokines in response to macrophage-activating lipopeptide-2 and lipopolysaccharide in toll-like receptor-2-deficient mice and CD36-deficient rats
    Kirschstein T.- Spatial learning and long-term potentiation in aged chronically epileptic rats
     - Inhibitory interneurons are not required for metabotropic glutamate receptor-dependent LTD in the hippocampal CA1 region
     - Status epilepticus leads to altered synaptic plasticity in dorsomedial striatum
    Kittel R. J.- Bruchpilot filaments accelerate vesicle reloading at active zones
     - The LEM-domain protein MAN1 is required for presynaptic function at the drosophila neuromuscular junction
    Kjaer M.- Dynamic adaptations of the extracellular matrix in tendon and muscle connective tissues to mechanical loading
    Kjaersgaard G.- Lithium impairs kidney development and inhibits glycogen synthase kinase-3
    Klaiber M.- The ANP/cGMP/cGMP-dependent protein kinase pathway counteracts angiotensin II-stimulated calcium mobilization in cardiac myocytes
    Klapperstuck M.- Sphingosine-1-phosphate receptors stimulate macrophage plasma membrane actin assembly via ADP release, ATP synthesis and P2X7 receptor activation
    Klaus F.- PIKfyve-dependent regulation of the Cl- channel ClC-2
     - Regulation of the EAAT3 by PIKfyve
     - SGK1 and PIKfyve in the regulation of the Ca2+ channel TRPV6
    Klebingat K.-J.- Superoxide formation in human intrarenal arteries is mainly due to NADPH oxidase activity and contributes to endothelium-dependent vasodilation
    Klede S.- Dynamic regulation of titin stiffness in the Z/I region of the sarcomere
    Kleggetveit I.-P.- Effects of local lidocaine application on conductive properties of human C-fibers
    Klein N.- Protective effect of the angiotensin metabolite angiotensin-(17) in experimental acute lung injury
    Klein T.- Hypoxia prolonged effects of the central cholinergic modulation of breathing after organophosphorus poisoning in the perfused brainstem preparation of rat
     - Distribution of acetylcholine receptor subtypes in the respiratory related areas of the rat brainstem
    Kleinschmidt M.- Expression of friend of GATA (FOG)-2 in hypoxia is modulated by HIF-1
     - Hypoxia-inducible factor-1 affects cardiac function during chronic pressure overload
     - HIF-1 affects etoposide-resistance and MDR-1 efflux activity
    Kleta R.- ACE2 and collectrin are tissue-specific associated proteins of the amino acid transporter B0AT1 and B0AT1-Hartnup-causing mutations
    Klier M.- Carbonic anhydrase II supports lactate transport via monocarboxylate transporter isoform 4, but not via isoform 2
    Klingberg H.- HL-1mouse cardiomyocyte death after simulated ischemia and reperfusion is dependent on pHo: Roles of the Na+/H+ exchanger NHE1, and the Ca2+-independentphospholipase A2 PLA2-VI
    Klingel K.- SGK1-dependent downregulation of Foxo3a promotes growth of colon tumors
    Klitzing C.- Characterization of AMP-hydrolysis in human internal mammary artery
    Klocker N.- Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP
     - Tuesday, March 24, Audimax, Poster Area EPoster Session: Transporters and channelsModerators: K. Benndorf (Jena)S. Grnder (Aachen) The increase in AMPA receptor surface expression by auxAMPARs critically depends on receptor conformation
     - A novel family of proteins that control trafficking and gating of AMPA receptors
     - AuxAMPARs promote surface expression of AMPA receptors by selective ER export
    Klockner U.- Tuesday, March 24, Audimax, Poster Area FPoster Session: Contractile mechanisms andcardiac functionsModerators: K. Brixius (Kln)P. Sasse (Bonn) Superoxide and nitric oxide differentially modulate calcium transients and contraction in aged murine ventricular myocytes
    Klokkers J.- Cyclosporin A induced apoptosis in primary cultured inner medullary collecting duct cells correlates with increased TNF expression
     - Atrial natriuretic peptide antagonizes the vasopressin mediated water permeability in inner medullary collecting duct cells via proteinkinase G
    Klyuch B. P.- Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone
    Knappe U.- Effects of smooth muscle sensitized for light radiation with 5-aminolaevulinic acid and Bay K 8644
    Knies R.- Tuesday, March 24, Hall 3Oral SessionEndothelial cell biology: NO, NADPH oxidaseChairpersons: H. Morawietz (Dresden)U. Pohl (Mnchen) The 2-adrenoceptor antagonist ICI 118,551 relaxes pulmonary arteries via a Gi/o protein-dependent NO release
    Knorr C.- The role of peripheral and central cyclooxygenase products in the manifestation of brain-controlled sickness responses during localized inflammation induced by macrophage-stimulating lipopeptide-2
    Knufermann P.- LPS pretreatment or downregulation of TLR4-signalling induces HIF-1 accumulation and reduces cardiac ischemia-reperfusion injury in mice
     - Gender and Toll-like receptor signaling affect cardiac function in hypertrophy
    Koch E.- Influence of high-fat diet on murine vascular dynamics in LDLR knockout compared to C57BL/6 mice analyzed in vivo by Doppler Fourier Domain Optical Coherence Tomography
    Koch L.- Impaired cardiac function in old but not in young mice after IGF1-receptor knockout
    Kocher O.- Sunday, March 22, Audimax, Poster Area BPoster SessionYoung Investigator Award (Poster):Channels and transportModerators: J. Daut (Marburg)J. Leipziger (Aarhus, DK) The PDZ proteins NHERF1 and NHERF2 have distinct roles in G-protein coupled receptor regulation of CFTR-mediated intestinal anion secretion in vivo
    Kocks S. L.- Tuesday, March 24, Audimax, Poster Area APoster Session: Ca? and energy homeostasisModerators: U. Flgel (Dsseldorf)K.-D. Schlter (Giessen) HL-1 cardiomyocytes display isoform-specific functions of Akt1 and Akt2
    Kocks S.L.- Impaired cardiac function in old but not in young mice after IGF1-receptor knockout
    Koeditz J.- Normoxic destabilization of ATF-4 depends on proteasomal degradation
    Koenig X.- Conformational stability of the domain IV S6 segment of the voltage-gated Na channel as assessed by single- and double mutant perturbation analysis
    Koepsell H.- Tuesday, March 24, Audimax, Poster Area APoster Session: Kidney IIModerators: A. Kurtz (Regensburg)T. Volk (Erlangen) Organic cation transporter mediated cytotoxicity of irinotecan and paclitaxel
    Kogel A.- Monday, March 23, Audimax, Poster Area DPoster Session: Regulation and myocardial metabolism and functionModerators: T. Noll (Giessen)H.-G. Zimmer (Leipzig) PPAR activation limits the nonenzymatic effect of renin on cell lengths in adult ventricular cardiomyocytes
    Kogler H.- Hypoxia-inducible factor-1 affects cardiac function during chronic pressure overload
    Kohler R.- Ca2+-dependent K+-channels (IK1, SK3) mediate arteriolar dilation in a distinct stimulus-dependent fashion
     - Unusual role of Kv2 channels in rat posterior cerebral small arteries
    Kohling R.- Changes of GABAergic function in a model of chronic epilepsy
     - Status epilepticus leads to altered synaptic plasticity in dorsomedial striatum
     - Inhibitory interneurons are not required for metabotropic glutamate receptor-dependent LTD in the hippocampal CA1 region
     - Spatial learning and long-term potentiation in aged chronically epileptic rats
    Kohlstedt K.- Adipocyte-derived lipokines affect ACE expression and differentiation of human macrophages
    Kohnen A.- Hypoxia-induced vascular repair by progenitor cells requires the NADPH oxidase Nox2
    Kohrer K.- Accelerated atherosclerosis inapolipoprotein E/ecto-5nucleotidase (CD73) double-deficient mice
    Koka S.- Regulation of erythrocyte survival by AMP-activated protein kinase
     - Effect of cyclosporine onparasitemia and survival of Plasmodium berghei-infected mice
     - Azathioprine favorably influences the course of malaria
    Kolar F.- The BKCachannelis involved in the cardioprotectionafforded by in vivo hypoxic preconditioning or chronic hypoxia
    Kolb F. P.- Rehabilitation program for cerebellar patients presenting postural ataxia
     - Quantification of movement decomposition during a precision grip task comparable to picking a raspberry
    Kolbaev S. N.- Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone
    Kolbe K.- Thiol-dependent modulation of human EAG1 potassium channels
    Kolling J.- Differential influence of acute and chronic altitude training on apoptosis, proliferation and senescence of endothelial progenitor cells
    Kongsuphol P.- Regulatory volume decrease by the calcium activated chloride channel TMEM16A
     - Monday, March 23, Hall 3Oral SessionEpitheliumChairpersons: K. Kunzelmann (Regensburg)H. Oberleithner (Mnster) Defective Ca2+ dependent chloride secretion by TMEM16A knockdown
    Konietzny R.- Monday, 23 March, Audimax, Poster Area CPoster Session: Angiogenesis and hypoxiaModerators: T. Gloe (Mannheim)H. Sauer (Giessen) Retinoic acid enhance the erythropoietin genexpression under hypoxia in neuroblastoma cells
    Konig C.- Modulatory function ofPI3K in mu-opioid inhibition of voltage-gated calcium channels in nociceptive neurons
    Konnerth A.- MGluR/TRPC3-mediated synaptic Ca2+ signaling in spiny dendrites of central neurons
    Kopitzke L.- Endurance training in heterozygous ILK-deficient mice induces a hypertrophic cardiomyopathy
    Korbmacher C.- Tuesday, March 24, Hall 5Oral SessionEpithelial sodium channelsChairpersons: C. Korbmacher (Erlangen)K. Kusche-Vihrog (Mnster) Functional characterization of a loss-of-function mutation of human ENaC associated with atypical CF
     - Stimulatory effect of proteases on the epithelial sodium channel (ENaC) in confluent M-1 mouse renal collecting duct cells
     - Dual-specificity tyrosine phosphorylated and regulated kinase type 2 (DYRK2) activates the epithelial sodium channel (ENaC) in Xenopus laevis oocytes and in mouse distal nephron
     - Functional characterization of the -subunit of human ENaC
    Korbmacher J.- Tuesday, March 24, Hall 5Oral SessionEpithelial sodium channelsChairpersons: C. Korbmacher (Erlangen)K. Kusche-Vihrog (Mnster) Functional characterization of a loss-of-function mutation of human ENaC associated with atypical CF
    Korten S.- Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) mediated downregulation of arterial transcription factor Hey2 in human endothelial cells
    Kotlikoff M. I.- Cardiomyocytes within the vena cava are pacing the embryonic heart
    Kotter S.- Dynamic regulation of titin stiffness in the Z/I region of the sarcomere
    Kovac S.- Spreading depression triggers epileptiform activity in combined amygdala-hippocampus-neocortex tissues
    Kovacs R.- Neurometabolic coupling and oxygen demands during gamma oscillations in the hippocampus
    Kovermann P.- Tuesday, March 24, Hall 5Oral SessionTransportersChairpersons: P. Kovermann (Hannover)C. Wagner (Zrich, CH) Anion-dependent gating of EAAT4-associated anion channels
     - Anion-dependent conformational changes in glutamate transporters detected by fluorescence spectroscopy and voltage-clamp fluorometer
    Kraayvanger L.- Predictors of hypoventilation in obese patients with sleep-related breathing disorders
    Krabbenhoft A.- Sunday, March 22, Hall 4Oral SessionIntestinal transportChairpersons: M. Bleich (Kiel)G. Breves (Hannover) Gastric KNCQ1 channels provide luminal K+ to the H+/K+ ATPase, whereas Kir 4.1 channels are involved in secretory membrane recycling
     - Sunday, March 22, Audimax, Poster Area BPoster SessionYoung Investigator Award (Poster):Channels and transportModerators: J. Daut (Marburg)J. Leipziger (Aarhus, DK) The PDZ proteins NHERF1 and NHERF2 have distinct roles in G-protein coupled receptor regulation of CFTR-mediated intestinal anion secretion in vivo
     - Genetic deletion of NHE3, Slc26a6 (PAT1), Slc26a3 (DRA) and CFTR helps unravel the different pathways for duodenal HCO3- and H+ secretion in vivo
     - NBCn1 (Slc4a7) is a major HCO3- importer in murine duodenum and essential for basal and stimulated HCO3- secretion in vivo
     - Effect of genetic ablation of the acid/base transporters pNBC1, NHE1, NHE2, and Slc26a7, on gastric epithelial functions
    Kraehling H.- Extracellular matrix digestion depends on the matrix composition and on NHE1 activity
    Kraft R.- Functional and molecular analysis of glutamate receptors in human midbrain-derived neural precursor cells
    Kraft T.- Hypertrophic cardiomyopathy mutations R723G and R453C in the myosin head homain cause force enhancement by different mechanisms
    Krahling H.- Monday, March 23, Audimax, Poster Area BPoster Session: Cell migrationModerators: P. Dieterich (Dresden)C. Stock (Mnster) Carbonic anhydrase activity affects cell migration
     - Effects of modified 1-integrin expression on pH-dependent adhesion and migration of human melanoma cells
    Kramer A.- Delivery of herpes simplex virus type 1 genome through the nuclear pore complex
     - Caspases 3 and 9 pave the way for apoptosis through breakdown of the nuclear barrier
    Kramer S.- Parvovirus B19 protein NS1 inhibits Na+/H+ exchanger
    Kraus D.- Gender and Toll-like receptor signaling affect cardiac function in hypertrophy
    Kravchenko M.- Modulation of TRPC4 channels by calcium and via calmodulin-binding sites
    Krawczyk L. M.- Doxycycline treatment attenuates the development of aortic lesions in the mouse experimental model of vascular type of the Ehlers-Danlos syndrome
    Krehbiehl N.- Comparable parcrine effects of human progenitor cells irrespectively of the donor's age
     - Enhanced paracrine effects of cardiac progenitor cells depending on the underlying cardiovascular disease of the donor
    Kress M.- Sphingosine-1-phosphate (S1P) pathway for heat hyperalgesia in C57Bl6J mice
    Kreutz C.-P.- Monday, March 23, Hall 4Oral SessionVascular smooth muscle tone and vascular remodelingChairpersons: M. Hecker (Heidelberg)M. Kuhn (Wrzburg) Activation of the AMP-activated protein kinase by A769662 induces dilation in hamster microvessels
    Kreutz T.- Endurance exercise improves peroxiredoxin expression in erythrocytes of men suffering from type 2 diabetes
     - Exercise alters MCT1-protein expression and exercise-induced translocation in erythrocytes of men suffering from non-insulin dependent type II-diabetes
    Kreutzer J.- Expression of NADPH oxidase components during early mouse embryo development
    Kreutzmann P.- Possible explanation of the contrasting effects of minocycline in experiments on mitochondria and in a clinical study
    Krick W.- Sat-1 transport mechanisms and regulation of mRNA expression by oxalate precursors
    Krieg L.- Genetic or pharmacological CD26/DPP-IV inhibition combined with G-CSF administration enhances homing of stem cells and improves ventricular function after acute myocardial infarction
    Krieg T.- Non secretory cytosolic renin protects cardiac cells from necrosis induced by glucose depletion or ischemia/reperfusion injury in the rat
    Krieger A.- Recombinant and native Cav2.3 E-type voltage-gated Ca2+ channels interact with the molecular chaperone Hsp70
    Krippeit-Drews P.- Limiting KATP channel activity leads to upregulation of antioxidant enzymes and protection of pancreatic beta cells against oxidative stress
     - Bile acids affect electrical activity and [Ca2+]c in pancreatic beta cells
     - Altering AMPK activity affects pancreatic beta cell function
    Kron M.- Impaired K+-channel activity attenuates cyanide-induced hyperpolarization of CA1 pyramidal neurons in Mecp2-deficient mice
     - Neonatal brainstem is prone to the generation of spreading depression during severe hypoxia
    Kronlage M.- The molecular compass for macrophage chemotaxis
    Krstic D.- Pretreatment with L-arginine reverse redutionof brain Na+/K+ ATPase activity induced by homocysteine thiolactone in adult rats
    Krueger B.- Functional characterization of the -subunit of human ENaC
     - Tuesday, March 24, Hall 5Oral SessionEpithelial sodium channelsChairpersons: C. Korbmacher (Erlangen)K. Kusche-Vihrog (Mnster) Functional characterization of a loss-of-function mutation of human ENaC associated with atypical CF
    Krueger M.- Physiological differences between three step test designs in front crawl swimming
    Krug S. M.- Functional and molecular analyses of absorption enhancers in an epithelial cell model
    Krug S.M.- Tuesday, March 24, Hall 4Oral SessionKidney PhysiologyChairpersons: M. Gekle (Halle/Saale),F. Schweda (Regensburg) Tricellulin enhances the barrier for ions and for macromolecules depending on its localization within the tight junction
    Kruger M.- Dynamic regulation of titin stiffness in the Z/I region of the sarcomere
    Krull S.- Expression of friend of GATA (FOG)-2 in hypoxia is modulated by HIF-1
    Kuba K.- ACE2 and collectrin are tissue-specific associated proteins of the amino acid transporter B0AT1 and B0AT1-Hartnup-causing mutations
    Kubis H.-P.- Influence of a combined low-carbohydrate high intensity interval training intervention on insulin sensitivity, blood lipids and whole body metabolism in obese sedentary individuals
    Kucherenko Y.- Participation of leukotriene C4 in the regulation of suicidal erythrocyte death
    Kuebler W.- Protective effect of the angiotensin metabolite angiotensin-(17) in experimental acute lung injury
     - Inhaled nitric oxide improves left ventricular function and reduces infarct size during myocardial ischemia by the Robin Hood effect
    Kuehn C.- Anti-inflammatory thalidomide improves islet grafts survival and functions in a xenogenic environment
    Kuehn K.- Delivery of herpes simplex virus type 1 genome through the nuclear pore complex
    Kuhl D.- SGK1-dependent regulation of intestinal peptide transport
     - SGK1-dependent downregulation of Foxo3a promotes growth of colon tumors
    Kuhlmann C.- Sunday, March 22, Audimax, Poster Area APoster SessionYoung Investigator Award (Poster)Cardiovascular systemModerators: K. Brixius (Kln)U. Decking (Dsseldorf) Protein based nanoparticles for the efficient delivery of genes into brain endothelial cells
    Kuhn A.- The peptide-gated ion channel from Hydra magnipapillata is made of three homologous subunits
    Kuhn M.- Atrial natriuretic peptide stimulates microvascular endothelial permeability
     - Atrial (ANP) and B-type natriuretic peptides (BNP) stimulate endothelial matrix metalloproteinase secretion and postischemic endothelial regeneration
     - Regulation of guanylyl cyclase-A, the receptor for atrial natriuretic peptide, by alternative splicing
     - The ANP/cGMP/cGMP-dependent protein kinase pathway counteracts angiotensin II-stimulated calcium mobilization in cardiac myocytes
     - Posttranslational modifications of the GC-A receptor for atrial natriuretic peptide: Characterization by mass spectrometry application
    Kuhnel M. P.- Sphingosine-1-phosphate receptors stimulate macrophage plasma membrane actin assembly via ADP release, ATP synthesis and P2X7 receptor activation
    Kuhtz-Buschbeck J.P.- Tuesday, March 24, Audimax, Poster Area BPoster Session: Motor systemsModerators: F. P. Kolb (Mnchen)J. P. Kuhtz-Buschbeck (Kiel) Cortical representation of pelvic floor muscles - an fMRI study
    Kulozik F. P.- Is contraction or relaxation of rabbit psoas myofibrils rate-limited by Ca2+-regulated switch of the troponin complex?
    Kulozik F.P.- The impact of the FHC-associated mutation K183 of troponin I on the Ca2+-transients of cardiomyocytes
    Kumar S.- Sodium-bicarbonate co-transporter SLC4A7 modulates the mitochondrial pathway of apoptosis in coronary cells under ischemic stress
    Kummel D.- Gait abnormalities as an indicator for pain or structural joint damage in antigen-induced arthritis of the rat
    Kummer W.- Tuesday, March 24, Hall 4Oral SessionAnion transportChairpersons: J. Deitmer (Kaiserslautern)A. Schwab (Mnster) Nicotine activates chloride channels in mouse tracheal epithelium
     - The P2X7 receptor plays an important role in purinergic signaling pathways in alveolar macrophages
    Kunert A.- SGK1 and PIKfyve in the regulation of the Ca2+ channel TRPV6
    Kunert-Keil C.- Calcium-dependent translocation of TRPC3 channels to the sarcolemma of mouse skeletal muscle fibres
     - Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate background Ca2+ entry and muscle fatigue
    Kunit T.- Resveratrol inhibits stimulus-secretion-coupling and induces apoptosis in INS-1E rat insulinoma cells
    Kunzelmann K.- Tuesday, March 24, Audimax, Poster Area FPoster Session: LungModerators: K. Kunzelmann (Regensburg)H. Schillers (Mnster) ER localized and Pak2 phosphorylated bestrophin 1 confers receptor activation of epithelial Ca2+ dependet ion channels
     - Monday, March 23, Hall 3Oral SessionEpitheliumChairpersons: K. Kunzelmann (Regensburg)H. Oberleithner (Mnster) Defective Ca2+ dependent chloride secretion by TMEM16A knockdown
     - Annexin V binds to CFTR and regulates its endocytosis
     - Regulatory volume decrease by the calcium activated chloride channel TMEM16A
     - Control of ion transport by AMPK: Is it important?
    Kuper C.- COX-2-derived cyclopentenone prostaglandins stimulate the expression of the sHSP B-Crystallin in renal medullary cells during osmotic stress
     - EGF receptor signaling is involved in expression of osmoprotective TonEBP target gene aldose reductase under hypertonic conditions
    Kupsch K.- Possible explanation of the contrasting effects of minocycline in experiments on mitochondria and in a clinical study
    Kurig B.- Wednesday, March 25, Hall 4Oral SessionEndothelial cell biologyChairpersons: M. Cattaruzza (Heidelberg)T. Noll (Giessen) The cardiac ankyrin repeat protein (CARP) interacts with cytoplasmic -actin in migrating endothelial cells
    Kuro-o M.- Hyperaldosteronism in Klotho-deficient mice
    Kurtz A.- Systemic activation of the renin-angiotensin system causes stimulation of the intraocular renin-angiotensin system
     - Human renin promoter cAMP response sequences are important for the cell-specific expression of renin in the adult kidney
     - Impaired renal blood flow autoregulation due to compromised tubuloglomerular feedback in mice lacking connexin 40
     - Kidney-specific deficiency of PPAR results in increased mouse renin production
    Kurtz L.- Impaired renal blood flow autoregulation due to compromised tubuloglomerular feedback in mice lacking connexin 40
    Kurz E.- Muscle activation patterns of selected ankle muscles in haemophilic patients during bipedal upright standing depending on Orthopaedic Joint Score
    Kusch J.- Heterotetrameric olfactory CNG channels are activated by the ligand binding to the two CNGA2 subunits only
     - Relating ligand binding to gating in HCN2 channels
    Kusche-Vihrog K.- Characterization of the epithelial sodium channel delta subunit in human nasal epithelium
     - Epithelial Na+ channels of endothelial are regulated by aldosterone
     - Endothelial cell stiffness explored by a combination of fluorescence and atomic force microscopy
     - Nitric oxide release of individual endothelial cells
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    Kwapiszewska G.- The cytoskeletal protein paxillin is associated with pulmonary vascular remodeling
    Kzhyshkowska J.- Perspectives of mathematical modeling for understanding of intracellular signaling and vesicular trafficking in macrophages

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