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Acta Physiologica Congress

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Acta Physiologica 2009; Volume 195, Supplement 669
The 88th Annual Meeting of The German Physiological Society
3/22/2009-3/25/2009
Giessen, Germany

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    M
    Ma Y.- Monday, 23 March, Audimax, Poster Area CPoster Session: Angiogenesis and hypoxiaModerators: T. Gloe (Mannheim)H. Sauer (Giessen) Retinoic acid enhance the erythropoietin genexpression under hypoxia in neuroblastoma cells
    Mace O.- Monday, March 23, Hall 1Main SessionPhysiology and pathophysiology ofpulmonary epithelial ionJoint Symposium with the Excellence Cluster Cardiopulmonary System and SFB 547 Cardio-Pulmonary VasculatureChairpersons: W. Clauss (Giessen)R. E. Morty (Giessen) Regulation of Na+ transport by AMPK in human lung epithelial cells
    Mack A.- SGK1-dependent downregulation of Foxo3a promotes growth of colon tumors
    Madsen K.- Lithium impairs kidney development and inhibits glycogen synthase kinase-3
    Mahler N.- Monday, March 23, Hall 3Oral SessionRenal transport IChairpersons: C. Wagner (Zrich, CH)R. Warth (Regensburg) Cyclosporine A-induced increases of renal and hepatic MDR1 expression do not depend on renal MRP2
    Mahmud H.- Role of APC in erythrocte survival
     - Regulation of erythrocyte survival by AMP-activated protein kinase
     - Participation of leukotriene C4 in the regulation of suicidal erythrocyte death
    Maier S.- TASK-1 channels in cardiac muscle cells of murine and human heart
    Mair N.- Sphingosine-1-phosphate (S1P) pathway for heat hyperalgesia in C57Bl6J mice
    Mairbaurl H.- Beta-adrenergic stimulation prevents inhibition of alveolar Na-transport in hypoxia
    Makrides V.- ACE2 and collectrin are tissue-specific associated proteins of the amino acid transporter B0AT1 and B0AT1-Hartnup-causing mutations
    Malan D.- Endurance training in heterozygous ILK-deficient mice induces a hypertrophic cardiomyopathy
    Mall M.- Role of ENaC in the pathogenesis and as a therapeutic target for cystic fibrosis lung disease
    Mally S.- The role of the Ca2+ channels TRPC1 and TRPC6 in neutrophil migration
     - Monday, March 23, Audimax, Poster Area BPoster Session: Cell migrationModerators: P. Dieterich (Dresden)C. Stock (Mnster) Carbonic anhydrase activity affects cell migration
     - Effects of modified 1-integrin expression on pH-dependent adhesion and migration of human melanoma cells
    Malmsten M.- Arteriosclerosis prophylaxis by Ginkgo biloba (EGb 761) in patients with metabolic syndrome
     - Possible atheroprotective effects of hyaluronic acid from the endothelial surface layer
    Mannigel I.- Monday, March 23, Hall 4Oral SessionVascular inflammation: Basic aspectsChairpersons: H.-J. Schnittler (Dresden)B. Walzog (Mnchen) The mammalian actin binding protein 1 (mAbp1) is required for firm arrest and intraluminal crawling of neutrophils during the acute inflammatory response
    Manns M.- Preserved abundance but functional dysregulation of Na+/H+ exchanger isoform NHE3 in the small and large intestine in CD45RBhigh transfer colitis mice with diarrhea
     - Monday, March 23, Audimax, Poster Area EPoster Session: Gut and epithelial transporters IModerators: M. Ritter (Salzburg, AT)J. Roth (Giessen) Dual role of the Na+/H+ exchanger isoform 3 for PEPT1-mediated H+/dipeptide cotransport in native murine intestine
     - Secretagogue stimulation enhances NBCe1-B (electrogenic intestinal/pancreatic Na+/HCO3- cotransporter) surface expression in murine colonic crypts
     - Genetic deletion of NHE3, Slc26a6 (PAT1), Slc26a3 (DRA) and CFTR helps unravel the different pathways for duodenal HCO3- and H+ secretion in vivo
     - Sunday, March 22, Hall 4Oral SessionIntestinal transportChairpersons: M. Bleich (Kiel)G. Breves (Hannover) Gastric KNCQ1 channels provide luminal K+ to the H+/K+ ATPase, whereas Kir 4.1 channels are involved in secretory membrane recycling
    Marciniak-Czochra A.- Perspectives of mathematical modeling for understanding of intracellular signaling and vesicular trafficking in macrophages
    Marcora S.- Influence of a combined low-carbohydrate high intensity interval training intervention on insulin sensitivity, blood lipids and whole body metabolism in obese sedentary individuals
    Marcussen N.- Lithium impairs kidney development and inhibits glycogen synthase kinase-3
    Markowski P.- LPS pretreatment or downregulation of TLR4-signalling induces HIF-1 accumulation and reduces cardiac ischemia-reperfusion injury in mice
    Marks D.- Tuesday, March 24, Audimax, Poster Area DPoster Session: Central homeostatic regulationModerators: H. Braun (Marburg)R. Gerstberger (Giessen) Activation of (non-)nitrergic hypothalamic MnPO neurons due to systemic thermal and osmoregulatory stimulations in the rat
     - Functional expression of the apelin-12 receptor protein APJ in rat hypothalamic nuclei (PVN and MnPO) involved in body fluid homeostasis and temperature regulation
     - The role of peripheral and central cyclooxygenase products in the manifestation of brain-controlled sickness responses during localized inflammation induced by macrophage-stimulating lipopeptide-2
    Markwardt F.- Sphingosine-1-phosphate receptors stimulate macrophage plasma membrane actin assembly via ADP release, ATP synthesis and P2X7 receptor activation
    Maroski J.- Possible atheroprotective effects of hyaluronic acid from the endothelial surface layer
    Martens H.- Ruminal epithelial cells express a conductance for propionate
    Martin C.- NHE1-activity creates an intracellular pH-gradient in human melanoma cells
    Martin M.- ACE-inhibiting peptides in hypoallergenic infant formulas lower blood pressure and induce cardiac remodeling in the SHR-model
    Martins J. R.- Monday, March 23, Hall 3Oral SessionEpitheliumChairpersons: K. Kunzelmann (Regensburg)H. Oberleithner (Mnster) Defective Ca2+ dependent chloride secretion by TMEM16A knockdown
    Marx R.- Upregulation of neuronal sodium current density in hippocampal neurons by thyroid hormone involves bFGF and glial cells
    Mas Gomez N.- Mice have light-induced retinal damage at low light intensity
    Masumiya H.- Visualisation of respiratory activity in breathing slices from mice using voltage-sensitive dyes
    Matinmehr F.- Hypertrophic cardiomyopathy mutations R723G and R453C in the myosin head homain cause force enhancement by different mechanisms
    Matschke K.- Improvement of vessel graft storage in a new preservation solution on human internal mammary artery (HIMA)
     - Characterization of AMP-hydrolysis in human internal mammary artery
    Matschke V.- Influence of a combined low-carbohydrate high intensity interval training intervention on insulin sensitivity, blood lipids and whole body metabolism in obese sedentary individuals
    Matter C.- Tuesday, March 24, Audimax, Poster Area GPoster Session: Vascular function and remodelingModerators: R. P. Brandes (Frankfurt a. M.)G. Siegel (Berlin) Diet-induced obesity increases plasma aldosterone and impairs endothelial function
    Matthey M.- Tuesday, March 24, Hall 3Oral SessionEndothelial cell biology: NO, NADPH oxidaseChairpersons: H. Morawietz (Dresden)U. Pohl (Mnchen) The 2-adrenoceptor antagonist ICI 118,551 relaxes pulmonary arteries via a Gi/o protein-dependent NO release
    Matzner N.- Effects of glucocorticoids on regulation of cytosolic Ca2+ activityin dendritic cells
     - Blunted activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3
     - Ca2+-dependent functions in peptidoglycan-stimulated mouse dendritic cells
     - Regulation of calcium signaling in dendritic cells by 1,25-dihydroxyvitamin D3
     - Non-selective cation channel-mediated Ca2+-entry, modulation of calcium/calmodulin-dependent kinase II (CaMKII) and G2/M cell cycle arrest in irradiated K562 leukemia cells
    Mawrin C.- A conserved splice variant of NaV1.8 voltage-gated sodium channel from human dorsal root ganglion neurons
    Maxeiner H.- Enhanced paracrine effects of cardiac progenitor cells depending on the underlying cardiovascular disease of the donor
     - Comparable parcrine effects of human progenitor cells irrespectively of the donor's age
    Mayer A.- Metabolic adaptation of tumor-initiating cells is a key factor determining angiogenesis in a sarcoma allograft model
    Mayer V.- Impact of M3 and M5 acetylcholine receptors on cholinergic dilatation of mesenteric arteries in genetically modified mice
    McDermott B.- Intermedin: A novel counter-regulatory peptide in the cardiovascular system
    McDonnell N. B.- Doxycycline treatment attenuates the development of aortic lesions in the mouse experimental model of vascular type of the Ehlers-Danlos syndrome
    McKenna W. J.- Hypertrophic cardiomyopathy mutations R723G and R453C in the myosin head homain cause force enhancement by different mechanisms
    McTavish N.- The role of SGK1 in the glucocorticoid-induced activation of the -Enacgene promoter
    Mederos y Schnitzler M.- TRPC1 suppresses the Ca2+ permeability in heteromeric channel complexes without effects on arterial tone
     - Mutation of the critical histidine residue in the T1 domain of Kv2.1 prevents the heteromeric assembly of Kv2.1/Kv6.x channels
    Medina C.- Sunday, March 22, Audimax, Poster Area CPoster SessionYoung Investigator Award (Poster):Cell mobilization and cell signalingModerators: D. W. Richter (Gttingen)A. Sachinidis (Kln) Effect of TGF-1 and inflammatory cytokines on EMT and cell migration in alveolar epithelial cells
    Mehl U.- Genetic or pharmacological CD26/DPP-IV inhibition combined with G-CSF administration enhances homing of stem cells and improves ventricular function after acute myocardial infarction
    Mehnert C.- Characterization of AMP-hydrolysis in human internal mammary artery
     - Sunday, March 22, Hall 2Oral SessionExtracellular nucleotides and ischemiaChairpersons: U. Decking (Dsseldorf)A. Deussen (Dresden) Mathematical modeling of the AMP conversion to adenosine in flow experiments with human internal mammary arteries
    Mehta A.- Control of ion transport by AMPK: Is it important?
    Meier J. C.- Tuesday, March 24, Audimax, Poster Area EPoster Session: Neural degeneration and agingModerators: D. Bsselberg (El Paso, US),M. Diener (Giessen) Fragile X mental retardation protein (FMRP) stimulates translation of the human achaete-scute homologue-1 (hASH1) mRNA
    Meindl T.- Rehabilitation program for cerebellar patients presenting postural ataxia
     - Quantification of movement decomposition during a precision grip task comparable to picking a raspberry
    Meissner A.- The effects of sphingosine-1-phosphate on vascular smooth muscle cells are negatively controlled by the cystic fibrosis transmembrane regulator (CFTR)
    Meissner M.- Differentiation between homo- and heteromultimers of the ionotropic steroid receptors TRPM3 and TRPM1
    Meissner S.- Influence of high-fat diet on murine vascular dynamics in LDLR knockout compared to C57BL/6 mice analyzed in vivo by Doppler Fourier Domain Optical Coherence Tomography
    Mengual R.- Monday, March 23, Hall 1Main SessionPhysiology and pathophysiology of K2P -channelsSymposium of the Working Group Heart and Circulation PhysiologyChairpersons: J. Daut (Marburg)R. Warth (Regensburg) Invalidation of TASK1 K+ channels disrupts adrenal gland zonation and mineralocorticoid homeostasis
    Mentrup V.- Lasp-2 expression, localization, and ligand interactions:A new Z-disc scaffolding protein
    Mercorillo D.- The non-gastric H+/K+-ATPase ATP12A exerts an anti-apoptotic effect on butyrate-treated myelomonocytic HL60 cells
    Mertel S.- Bruchpilot filaments accelerate vesicle reloading at active zones
    Mertens M.- Protective effect of the angiotensin metabolite angiotensin-(17) in experimental acute lung injury
    Messlinger K.- Upregulation of CGRP- and nNOS-immunoreactive neurons in the rat trigeminal ganglion after infusion of a NO donor
     - New insights into the activity-dependent regulation of axonal conduction velocity
    Mester J.- Determination of lactate influx rates into erythrocytes after maximal exercise
     - Effects of different warm up intensities on lactate distribution in different blood compartments and power output
     - Effects of active or passive recovery between high-intensity cycling bouts on power output, lactate and pH time course
     - Effects of sodium bicarbonate ingestion on pH and lactate distribution in different blood compartments after short term high intensity exercise
     - Differential influence of acute and chronic altitude training on apoptosis, proliferation and senescence of endothelial progenitor cells
     - Physiological differences between three step test designs in front crawl swimming
    Metzler D.- Ileal smooth muscle contractile activity of neonatal mice is less sensitive to cAMP/PKA than to cGMP/PKG signaling
    Meusel M.- COX-inhibition restores renal organic anion transport and positively influences renal outcome in a rat model of ischemic acute kidney injury
    Meuth P.- Wednesday, March 25, Hall 2Main SessionMathematical models in physiologyChairpersons: A. Deussen (Dresden)E.-J. Speckmann (Mnster) A thalamo-cortical neuronal network model targets absence epilepsy
    Meyer C.- Systemic activation of the renin-angiotensin system causes stimulation of the intraocular renin-angiotensin system
    Meyer M.- From physics to physiology - transfer of knowledge within a practical course in physics
    Meyer R.- LPS pretreatment or downregulation of TLR4-signalling induces HIF-1 accumulation and reduces cardiac ischemia-reperfusion injury in mice
     - Effect of a new type of muscarinic acetylcholine receptor activator on sarcomere shortening in isolated murine cardiac myocytes
     - Gender and Toll-like receptor signaling affect cardiac function in hypertrophy
    Mieth A.- sEH-deficiency attenuates neointima formation in the femoral artery cuff model of hyperlipidemic mice
    Milatz S.- Tuesday, March 24, Hall 4Oral SessionKidney PhysiologyChairpersons: M. Gekle (Halle/Saale),F. Schweda (Regensburg) Tricellulin enhances the barrier for ions and for macromolecules depending on its localization within the tight junction
    Mildenberger S.- The influence of aldosterone and NaCl on vascular smooth muscle cells
     - Direct interaction of mineralocorticoid receptor and EGF receptor
    Milenkovic V.- Systemic activation of the renin-angiotensin system causes stimulation of the intraocular renin-angiotensin system
    Milkau M.- Ca2+-dependent K+-channels (IK1, SK3) mediate arteriolar dilation in a distinct stimulus-dependent fashion
    Miller M.- Effect of genetic ablation of the acid/base transporters pNBC1, NHE1, NHE2, and Slc26a7, on gastric epithelial functions
    Milosevic N.- Tumor-induced angiogenesis analyzed in confrontation cultures of multicellular tumor spheroids and embryonic stem cell-derived embryoid bodies
    Minge D.- Overexpressing somatodendritic A-type potassium channel subunits in hippocampal neurons
    Mintert-Jancke E.- Downregulation of GIRK subunits by RNA-interference in rat atrial myocytes reveals transcriptional coupling of Kir3.1 and Kir3.4
    Miqdad M.- Tuesday, March 24, Audimax, Poster Area CPoster Session: Cardiovascular pathophysiologyModerators: B. F. Becker (Mnchen)H.-G. Zimmer (Leipzig) The role of cytosolic Ca2+-oscillations for inflammation in human cerebrovascular endothelial cells after subarachnoid hemorrhage
     - Sunday, March 22, Hall 5Oral SessionCalcium signaling and calcium storesChairpersons: Y. Abdallah (Giessen)H. Sauer (Giessen) Ca2+-induced necrosis in human astrocytes after cerebral hemorrhage
    Mladenovic D.- L-NAME potentiate homocysteine-induced convulsions in adult rats
    Moch H.- Onconeuronal cerebellar degeneration-related antigen Cdr2 is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response
    Moder A.- Regulation of CD45 expression and correlation with apoptosis in myelomonocytic HL60 cells
    Moholt Hedensted H. C.- Long-term depression of pain perception in man affects peripheral receptive fields
    Mohr F.- Differentiation between homo- and heteromultimers of the ionotropic steroid receptors TRPM3 and TRPM1
    Mohr F. W.- Calcium-sensing receptor in the human heart
    Mohr K.- Effect of a new type of muscarinic acetylcholine receptor activator on sarcomere shortening in isolated murine cardiac myocytes
    Mohr-Andra M.- Effect of a new type of muscarinic acetylcholine receptor activator on sarcomere shortening in isolated murine cardiac myocytes
    Molenda N.- Real-time monitoring of cell elasticity and cytoskeletal dynamics in living cells with atomic force microscopy
     - CFTR expression controls the paracellular permeability of bronchial epithelium
    Moller K.- Migrating oligodendrocyte precursor cell somata swell prior to dislocation
    Molnar T.- Downregulation of Na+/H+ exchanger isoform 3 (NHE3) function, but not expression, in colonic mucosa of patients with ulcerative colitis may be related to loss of PDZK1 adaptor protein expression
    Momotani K.- Endothelium dependent modulation of phosphorylation of smooth muscle myosin phosphatase in brain vessels by the thromboxane A2 mimetic, U-46619
    Moneke I.- Sunday, March 22, Hall 3Oral SessionPulmonary pathophysiology and hypoxiaChairpersons: D. M. Katschinski (Gttingen)H. Scholz (Berlin) Deletion of the subunit of the large conductance calcium-activated potassium channel abrogates epoxyeicosatrienoic acid-induced pulmonary vasoconstriction
    Morawietz H.- Glucose-dependent regulation of chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) in human endothelial cells
     - Impaired vascular function in small resistance arteries of LOX-1 overexpressing mice on high-fat diet
     - Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) mediated downregulation of arterial transcription factor Hey2 in human endothelial cells
     - Influence of high-fat diet on murine vascular dynamics in LDLR knockout compared to C57BL/6 mice analyzed in vivo by Doppler Fourier Domain Optical Coherence Tomography
    Morgenstern A.- Tuesday, March 24, Hall 5Oral SessionMethods and teachingChairpersons: M. Diener (Giessen)P. B. Persson (Berlin) Detection and tracking of cells in confluent cell cultures within the framework of statistical pattern recognition
    Morrisseau C.- sEH-deficiency attenuates neointima formation in the femoral artery cuff model of hyperlipidemic mice
    Morsch M.- Modulation of the Ca2+ conductance of nicotinic acetylcholine receptors by the endogenous protein Lypd6
    Morschel M.- Distribution of acetylcholine receptor subtypes in the respiratory related areas of the rat brainstem
     - Hypoxia prolonged effects of the central cholinergic modulation of breathing after organophosphorus poisoning in the perfused brainstem preparation of rat
    Morty R. E.- Carbon monoxide rapidly impairs alveolar fluid clearance by inhibiting epithelial sodium channels
     - Lung epithelial Na+ channels are regulated by mechanical forces
     - Carbon monoxide modulates the activity of sodium channels in the alveolar epithelium: A role for ENaC?
    Moser M.- Kindlin-3 is essential for firm leukocyte adhesion during inflammation in vivo
    Mothet J.-P.- Modulation of glutamatergic synapses by the glial-derived D-serine in the prefrontal cortex
    Mottaghy K.- Oxygen diffusion through different liquid layers with and without surfactant in a physical model
    Motterlini R.- Carbon monoxide rapidly impairs alveolar fluid clearance by inhibiting epithelial sodium channels
     - Carbon monoxide modulates the activity of sodium channels in the alveolar epithelium: A role for ENaC?
    Mrochen N.- Effect of 1,25-dihydroxyvitamin D3 on macromineral homoeostasis of sheep fed different levels of calcium
    Mrowka R.- Tuesday, March 24, Audimax, Poster Area EPoster Session: Neural degeneration and agingModerators: D. Bsselberg (El Paso, US),M. Diener (Giessen) Fragile X mental retardation protein (FMRP) stimulates translation of the human achaete-scute homologue-1 (hASH1) mRNA
     - EazyClone: A user-friendly application for the development of cloning strategies
     - Seed based systematic discovery of specific transcription factor target genes
    Mueller B.- Characterization of AMP-hydrolysis in human internal mammary artery
    Mueller G.- Impaired vascular function in small resistance arteries of LOX-1 overexpressing mice on high-fat diet
     - Influence of high-fat diet on murine vascular dynamics in LDLR knockout compared to C57BL/6 mice analyzed in vivo by Doppler Fourier Domain Optical Coherence Tomography
    Mueller-Hoecker J.- Genetic or pharmacological CD26/DPP-IV inhibition combined with G-CSF administration enhances homing of stem cells and improves ventricular function after acute myocardial infarction
    Mufti S.- Enhanced paracrine effects of cardiac progenitor cells depending on the underlying cardiovascular disease of the donor
    Muhlradt P. F.- The role of peripheral and central cyclooxygenase products in the manifestation of brain-controlled sickness responses during localized inflammation induced by macrophage-stimulating lipopeptide-2
     - Fever, sickness behavior and circulating cytokines in response to macrophage-activating lipopeptide-2 and lipopolysaccharide in toll-like receptor-2-deficient mice and CD36-deficient rats
    Muller B.- Improvement of vessel graft storage in a new preservation solution on human internal mammary artery (HIMA)
    Muller C.- Role of CD73 (ecto-5-nucleotidase) on T-cell mediated immune response
     - Role of Ca2+-channels in the regulation of phagocytosis by retinal pigment epithelium
    Muller J.- Nox1, Nox2 and Nox4 are key regulators of mouse embryonic stem cell-derived cardiovascular differentiation
    Muller L.- NMDA receptor dysfunction in epilepsy
    Muller M.- H2O2-mediated modulation of cytosolic signaling and organelle function in rat hippocampus
     - Comparable parcrine effects of human progenitor cells irrespectively of the donor's age
     - Effects of sodium bicarbonate ingestion on pH and lactate distribution in different blood compartments after short term high intensity exercise
     - Enhanced hypoxia susceptibility in hippocampal slices from a mouse model of Rett Syndrome
     - Neonatal brainstem is prone to the generation of spreading depression during severe hypoxia
     - Impaired K+-channel activity attenuates cyanide-induced hyperpolarization of CA1 pyramidal neurons in Mecp2-deficient mice
    Muller T.- Regulation of guanylyl cyclase-A, the receptor for atrial natriuretic peptide, by alternative splicing
    Mullins J.- Wednesday, March 25, Hall 4Oral SessionVascular inflammation: Clinical aspectsChairpersons: W. Franz (Mnchen)A. Grlach (Mnchen) The renin-angiotensin system as a primary cause in the pathophysiology of polyarteritis nodosa in rats
    Munzel G.- Intermedin, a hypoxia-regulated cardiac gene, worsens post-ischemic recovery and increases the susceptibility to apoptosis
    Munzel T.- Regulation of erythrocyte survival by AMP-activated protein kinase
    Munzner G.- Monday, March 23, Audimax, Poster Area APoster Session: EpilepsyModerators: A. Draguhn (Heidelberg)S. Hefft (Freiburg) Effects of levetiracetam on principal cells and interneurons in hippocampal slices
    Murer H.- Tuesday, March 24, Audimax, Poster Area CPoster Session: Gut and epithelial transporters IIModerators: S. Amasheh (Berlin)U. Seidler (Hannover) Expression and dietary modulation of intestinal phosphate cotransporters
     - Differential regulation of three renal phosphate transporters by parathyroid hormone (PTH)
    Murgott J.- The Organum Vasculosum Laminae Terminalis (OVLT) as a central nervous sensor for putative exogenous and endogenous pyrogens
     - LPS, MDP and FSL-1 induced cellular activation in rat area postrema microglial cells
     - Purinoceptor mediated signaling in neuronal and glial cells of the rat hypothalamic median preoptic nucleus
     - Fever, sickness behavior and circulating cytokines in response to macrophage-activating lipopeptide-2 and lipopolysaccharide in toll-like receptor-2-deficient mice and CD36-deficient rats
    Murray F.- Impaired urinary concentration abilityin mice lacking adenylyl cyclase 6
    Muscher A.- Dietary N supply modulates jejunal glucose absorption in goats

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