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Acta Physiologica Congress

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Acta Physiologica 2009; Volume 195, Supplement 669
The 88th Annual Meeting of The German Physiological Society
3/22/2009-3/25/2009
Giessen, Germany

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    F
    Fabian A.- Monday, March 23, Hall 4Oral SessionTRP channelsChairpersons: A. Cavali (Homburg/Saar)A. Schwab (Mnster) TRPC1 channels guide migrating cells in chemokine gradients
     - Analysis and quantification of cell migration during chemotaxis
     - The role of the Ca2+ channels TRPC1 and TRPC6 in neutrophil migration
     - Extracellular ATP reduces paracellular endothelial permeability via mechanical relaxation
    Faehling M.- Untranslated regionsof the ENaC subunit mRNA act as targets forregulatory binding proteins in kidney cell lines
    Faenger B.- The back muscles of laboratory rats
     - In vivo intramuscular electrical stimulation of rat triceps brachii with a multichannel electrode array
    Fahling M.- Tuesday, March 24, Audimax, Poster Area EPoster Session: Neural degeneration and agingModerators: D. Bsselberg (El Paso, US),M. Diener (Giessen) Fragile X mental retardation protein (FMRP) stimulates translation of the human achaete-scute homologue-1 (hASH1) mRNA
     - Seed based systematic discovery of specific transcription factor target genes
    Fahlke C.- Tuesday, March 24, Hall 5Oral SessionTransportersChairpersons: P. Kovermann (Hannover)C. Wagner (Zrich, CH) Anion-dependent gating of EAAT4-associated anion channels
     - Anion-dependent conformational changes in glutamate transporters detected by fluorescence spectroscopy and voltage-clamp fluorometer
     - Sodium dependence of glutamate transport by a prokaryotic glutamate transporter
     - A myotonia-causing mutation in the selectivity filter of human ClC-1 channels affects slow gating
     - Cation binding by bacterial glutamate transporters characterized through equilibrium and stop flow tryptophane fluorescence
    Fakler B.- Tuesday, March 24, Audimax, Poster Area EPoster Session: Transporters and channelsModerators: K. Benndorf (Jena)S. Grnder (Aachen) The increase in AMPA receptor surface expression by auxAMPARs critically depends on receptor conformation
     - Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP
     - BKCa- Cav channel complexes
     - A novel family of proteins that control trafficking and gating of AMPA receptors
     - AuxAMPARs promote surface expression of AMPA receptors by selective ER export
    Falk V.- Calcium-sensing receptor in the human heart
    Fandrey J.- Regulation of cellular oxygen-sensor activity controlling hypoxia-dependent transcription in mammalian cells
     - Role of ROS in the regulation of HIF-1 by PHD2 under mild hypoxia
     - Induction of endotoxin tolerance mimics HIF-1 knockout and effects monocyte-endothelial interaction
     - Monday, 23 March, Audimax, Poster Area CPoster Session: Angiogenesis and hypoxiaModerators: T. Gloe (Mannheim)H. Sauer (Giessen) Retinoic acid enhance the erythropoietin genexpression under hypoxia in neuroblastoma cells
     - The cellular activity of prolyl-hydroxylase 2 is upregulated by nitric oxide
     - LPS pretreatment or downregulation of TLR4-signalling induces HIF-1 accumulation and reduces cardiac ischemia-reperfusion injury in mice
    Faraji H.- Effect of different rest intervals during resistance training on growth hormone, testosterone and blood lactate
    Faria D.- Annexin V binds to CFTR and regulates its endocytosis
    Farkas K.- Downregulation of Na+/H+ exchanger isoform 3 (NHE3) function, but not expression, in colonic mucosa of patients with ulcerative colitis may be related to loss of PDZK1 adaptor protein expression
    Fasshauer M.- H2O2-mediated modulation of cytosolic signaling and organelle function in rat hippocampus
    Fassler R.- Kindlin-3 is essential for firm leukocyte adhesion during inflammation in vivo
    Fauler M.- Sunday, March 22, Hall 5Oral SessionSignaling in skeletal and smooth muscleChairpersons: K. Jurkat-Rott (Ulm)S. Wenzel (Giessen) Activation of the Na+/K+/2Cl--cotransporter in mammalian skeletal muscle
     - Amphotericin B induced cation leak in skeletal muscle membranes and its implications for familial hypokalemic periodic paralysis
     - Tuesday, March 24, Hall 3Oral SessionCI? channels and non-selective cation channelsChairpersons: C. Fahlke (Hannover)K. Jurkat-Rott (Ulm) Cellular Na+ overload and K+-dependent depolarization indicate a nonselective cation leak
    Fechner L.- cAMP affects Ca2+ signaling in salivary glands of the blowfly Calliphora vicina
    Fedorenko O.- PIP5k2A-dependent regulation of the excitatory amino acid transporter EAAT3
    Feil R.- The ANP/cGMP/cGMP-dependent protein kinase pathway counteracts angiotensin II-stimulated calcium mobilization in cardiac myocytes
    Feil S.- The ANP/cGMP/cGMP-dependent protein kinase pathway counteracts angiotensin II-stimulated calcium mobilization in cardiac myocytes
    Fels J.- Nitric oxide release of individual endothelial cells
     - Epithelial Na+ channels of endothelial are regulated by aldosterone
    Felsenberg D.- Contribution of altered microvascular responses to orthostatic intolerance after simulated exposure to microgravity
    Feng Z.- Effect of genetic ablation of the acid/base transporters pNBC1, NHE1, NHE2, and Slc26a7, on gastric epithelial functions
     - Sunday, March 22, Hall 4Oral SessionIntestinal transportChairpersons: M. Bleich (Kiel)G. Breves (Hannover) Gastric KNCQ1 channels provide luminal K+ to the H+/K+ ATPase, whereas Kir 4.1 channels are involved in secretory membrane recycling
    Fenton R. A.- Role of ferroportin-1 (FPN-1) in renal iron (Fe) handling
    Ferraro T.- Towards a better understanding of SK channel physiology and pharmacology
    Fesus G.- TRPC1 suppresses the Ca2+ permeability in heteromeric channel complexes without effects on arterial tone
    Fetting D.- Novel Cav1.2 and PMCA4b interacting PDZ domain containing proteins
    Fietze I.- Sunday, March 22, Hall 4Oral SessionAdaptive processes in sleep and exerciseChairpersons: M. E. Schlfke (Hagen)P. Wahl (Kln) Sleep stages modify the coupling of respiration and heartbeat
    Figulla H.-R.- Investigating the interplay of NO and ROS during cardiomyocyte differentiation from mouse embryonic stem cells
     - Characterisation of the 5-lipoxygenase pathway and leukotriene receptors in differentiating mouse embryonic stem cell derived embryoid bodies
     - Nox1, Nox2 and Nox4 are key regulators of mouse embryonic stem cell-derived cardiovascular differentiation
     - Phosphoinositide 3-kinases (PI3Ks) control early steps of cardiovascular differentiation of mouse embryonic stem cells
     - Metabolic pathways regulate P-glycoprotein gene expression via reactive oxygen species
     - NAD(P)H oxidases are key regulators of cardiomyocyte differentiation from embryonic stem cells
    Filippow N.- Tuesday, March 24, Audimax, Poster Area BPoster Session: Motor systemsModerators: F. P. Kolb (Mnchen)J. P. Kuhtz-Buschbeck (Kiel) Cortical representation of pelvic floor muscles - an fMRI study
    Finke C.- A computer modeling study of neuronal sensitivity and synchronization at tonic-to-bursting transitions
    Finkensieper A.- Phosphoinositide 3-kinases (PI3Ks) control early steps of cardiovascular differentiation of mouse embryonic stem cells
     - Tumor-induced angiogenesis analyzed in confrontation cultures of multicellular tumor spheroids and embryonic stem cell-derived embryoid bodies
     - Characterisation of the 5-lipoxygenase pathway and leukotriene receptors in differentiating mouse embryonic stem cell derived embryoid bodies
    Fischer J.- Accelerated atherosclerosis inapolipoprotein E/ecto-5nucleotidase (CD73) double-deficient mice
    Fischer M.- Enhanced hypoxia susceptibility in hippocampal slices from a mouse model of Rett Syndrome
     - A myotonia-causing mutation in the selectivity filter of human ClC-1 channels affects slow gating
    Fischer M. J.- Upregulation of CGRP- and nNOS-immunoreactive neurons in the rat trigeminal ganglion after infusion of a NO donor
    Fischer M. S.- In vivo intramuscular electrical stimulation of rat triceps brachii with a multichannel electrode array
     - The back muscles of laboratory rats
    Fischer S. S.- Hyperaldosteronism in Klotho-deficient mice
    Fischer T.- ATIP-1 gene trapping provides first evidence for an important physiological function of ATIP-1 in the heart
    Fissler B.- ATIP-1 gene trapping provides first evidence for an important physiological function of ATIP-1 in the heart
    Fisslthaler B.- Chronic hypoxia-induced pulmonary hypertension and pulmonary vascular remodeling are linked to the downregulation of the soluble epoxide hydrolase
     - The AMP-activated protein kinase exerts anti-inflammatory effects in the endothelium by activating MEF2A and increasing KLF2 and eNOS expression
     - Interfering with the association of A kinase anchoring proteins (AKAPs) to PKA prevents the fluid shear stress induced phosphorylation of eNOS in endothelial cells
     - Angiotensin II impairs endothelial function through PYK2-dependent tyrosine phosphorylation and inactivation of eNOS
    Flach B.- Tuesday, March 24, Hall 5Oral SessionMethods and teachingChairpersons: M. Diener (Giessen)P. B. Persson (Berlin) Detection and tracking of cells in confluent cell cultures within the framework of statistical pattern recognition
    Flacke J.-P.- Sodium-bicarbonate co-transporter SLC4A7 modulates the mitochondrial pathway of apoptosis in coronary cells under ischemic stress
    Fleischmann B.- Tuesday, March 24, Hall 3Oral SessionEndothelial cell biology: NO, NADPH oxidaseChairpersons: H. Morawietz (Dresden)U. Pohl (Mnchen) The 2-adrenoceptor antagonist ICI 118,551 relaxes pulmonary arteries via a Gi/o protein-dependent NO release
     - Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP
     - Endurance training in heterozygous ILK-deficient mice induces a hypertrophic cardiomyopathy
     - Pregnancy induced cardiovascular adaptation in mouse
     - Cardiomyocytes within the vena cava are pacing the embryonic heart
    Fleming I.- sEH-deficiency attenuates neointima formation in the femoral artery cuff model of hyperlipidemic mice
     - Angiotensin II impairs endothelial function through PYK2-dependent tyrosine phosphorylation and inactivation of eNOS
     - Interfering with the association of A kinase anchoring proteins (AKAPs) to PKA prevents the fluid shear stress induced phosphorylation of eNOS in endothelial cells
     - The AMP-activated protein kinase exerts anti-inflammatory effects in the endothelium by activating MEF2A and increasing KLF2 and eNOS expression
     - Activation of AMP-activated protein kinase protects endothelial barrier against reperfusion-induced failure
     - Chronic hypoxia-induced pulmonary hypertension and pulmonary vascular remodeling are linked to the downregulation of the soluble epoxide hydrolase
     - Sunday, March 22, Hall 3Oral SessionPulmonary pathophysiology and hypoxiaChairpersons: D. M. Katschinski (Gttingen)H. Scholz (Berlin) Deletion of the subunit of the large conductance calcium-activated potassium channel abrogates epoxyeicosatrienoic acid-induced pulmonary vasoconstriction
     - Adipocyte-derived lipokines affect ACE expression and differentiation of human macrophages
     - Cytochrome P450-derived metabolites of nitro-fatty acids are signaling molecules
    Flockerzi V.- Modulation of TRPC4 channels by calcium and via calmodulin-binding sites
    Flogel U.- Accelerated collateral vessel growth in CD73-/- mice after hindlimb ischemia revealed by in vivo 3D magnetic resonance angiography
     - Comparative phosphoproteome analysis of NO induced heart failure
     - Sunday, March 22, Hall 3Oral SessionRespiratory inflammation and gas exchangeChairpersons: G. Gros (Hannover)W. Kuebler (Berlin) Early detection of pneumonia by 19F magnetic resonance imaging
     - Atrial (ANP) and B-type natriuretic peptides (BNP) stimulate endothelial matrix metalloproteinase secretion and postischemic endothelial regeneration
    Florea A.-M.- Tuesday, March 24, Audimax, Poster Area BPoster Session: Cell death and survivalModerators: G. Euler (Giessen),V. Shahin (Mnster) Expression of DNA-methyltransferases and DNA-methyl-binding proteins in intrinsic and UVB induced extrinsic skin ageing: a pilot study
     - Indications of Ca2+ pools which are involved in As2O3 mediated [Ca2+]i changes
    Floride E.- Participation of leukotriene C4 in the regulation of suicidal erythrocyte death
     - Regulation of erythrocyte survival by AMP-activated protein kinase
    Foglein Á.- Stimulatory effect of proteases on the epithelial sodium channel (ENaC) in confluent M-1 mouse renal collecting duct cells
    Foller M.- Colon tumors express functional membrane androgen receptors that trigger pro-apoptotic responses
     - SGK1 and PIKfyve in the regulation of the Ca2+ channel TRPV6
     - Regulation of erythrocyte survival by AMP-activated protein kinase
     - Participation of leukotriene C4 in the regulation of suicidal erythrocyte death
     - Involvement of PI3K/AKT pathway in the hypoglycemic effects of saponins from Helicteres isora
     - Endothelin receptor stimulation protects from suicidal erythrocyte death
     - Role of APC in erythrocte survival
     - Azathioprine favorably influences the course of malaria
     - Suicidal erythrocyte death associated with cholestasis
     - Parvovirus B19 protein NS1 inhibits Na+/H+ exchanger
     - SGK1-dependent downregulation of Foxo3a promotes growth of colon tumors
     - Decreased susceptibility of the PDK1 hypomorphic mouse to tumor growth upon chemical cancerogenesis
     - Stimulation of the Na+-glucose cotransporter SGLT1 by AMP-activated protein kinase
     - PIKfyve-dependent regulation of the Cl- channel ClC-2
    Follin Larsen B.- Long-term depression of pain perception in man affects peripheral receptive fields
    Foltz W.- The antioxidant n-acetylcysteine reduces L-type Ca2+ current density and ameliorates hypertrophy in cardiomyocytes of rats with ascending aortic stenosis
    Fontana P.- Connexin 37: A modifier gene in atherosclerosis and thrombosis
    Forsch E.- NGF induces long-term changes in axonal excitability of mechano-insensitive C-afferents in pig skin, in vivo
    Forst S.- Biglycan: A negative regulator of cardiac elastin expression in diabetic hearts
     - From risk to heart failure in mice: Identification of UCP-2 and biglycan as potential risk factors in the left ventricle leading to severe heart failure
     - The arginine competition: eNOS deficiency and polyamine metabolism
     - Induction of diabetes like hyperfiltration in heterozygous eNOS mice overexpressing TGF-b1 does not depend on changes in the mRNA expression of fibrotic markers
    Forstera B.- Tuesday, March 24, Audimax, Poster Area EPoster Session: Neural degeneration and agingModerators: D. Bsselberg (El Paso, US),M. Diener (Giessen) Fragile X mental retardation protein (FMRP) stimulates translation of the human achaete-scute homologue-1 (hASH1) mRNA
    Fortmann T.- Analysis and quantification of cell migration during chemotaxis
     - Monday, March 23, Hall 4Oral SessionTRP channelsChairpersons: A. Cavali (Homburg/Saar)A. Schwab (Mnster) TRPC1 channels guide migrating cells in chemokine gradients
    Fouquet W.- Bruchpilot filaments accelerate vesicle reloading at active zones
    Francino A.- Hypertrophic cardiomyopathy mutations R723G and R453C in the myosin head homain cause force enhancement by different mechanisms
    Frank E.- Genetic or pharmacological CD26/DPP-IV inhibition combined with G-CSF administration enhances homing of stem cells and improves ventricular function after acute myocardial infarction
    Frank M.- Localisation of K+ channel subunits in lipid rafts and modulation of K+ currents by membrane cholesterol content in rat left ventricular myocytes
    Franz W.- Genetic or pharmacological CD26/DPP-IV inhibition combined with G-CSF administration enhances homing of stem cells and improves ventricular function after acute myocardial infarction
     - Programming and selection of pluripotent stem cells towards distinct cardiovascular cell types
    Fraser S. A.- Stimulation of the Na+-glucose cotransporter SGLT1 by AMP-activated protein kinase
    Frede S.- LPS pretreatment or downregulation of TLR4-signalling induces HIF-1 accumulation and reduces cardiac ischemia-reperfusion injury in mice
     - Induction of endotoxin tolerance mimics HIF-1 knockout and effects monocyte-endothelial interaction
    Freitag P.- Induction of endotoxin tolerance mimics HIF-1 knockout and effects monocyte-endothelial interaction
     - Monday, 23 March, Audimax, Poster Area CPoster Session: Angiogenesis and hypoxiaModerators: T. Gloe (Mannheim)H. Sauer (Giessen) Retinoic acid enhance the erythropoietin genexpression under hypoxia in neuroblastoma cells
    Frese S.- Determination of lactate influx rates into erythrocytes after maximal exercise
     - Analysis of intramuscular myosin heavy-chain (MyHC) pattern in single muscle fibers with focus on fast twitch fiber type II by using laser microdissection and qRT-PCR
    Freudinger R.- Novel Cav1.2 and PMCA4b interacting PDZ domain containing proteins
     - Dysregulation of hypothalamic-pituitary-adrenal hormone secretion in SPRED2-deficient mice
    Freyer M.- Monday, March 23, Hall 3Oral SessionRenal transport IChairpersons: C. Wagner (Zrich, CH)R. Warth (Regensburg) Cyclosporine A-induced increases of renal and hepatic MDR1 expression do not depend on renal MRP2
    Frisch A.- The influence of aldosterone and NaCl on vascular smooth muscle cells
    Fromm M.- Functional and molecular analyses of absorption enhancers in an epithelial cell model
     - Tuesday, March 24, Hall 4Oral SessionKidney PhysiologyChairpersons: M. Gekle (Halle/Saale),F. Schweda (Regensburg) Tricellulin enhances the barrier for ions and for macromolecules depending on its localization within the tight junction
    Frommhold D.- Monday, March 23, Hall 4Oral SessionVascular inflammation: Basic aspectsChairpersons: H.-J. Schnittler (Dresden)B. Walzog (Mnchen) The mammalian actin binding protein 1 (mAbp1) is required for firm arrest and intraluminal crawling of neutrophils during the acute inflammatory response
    Fronius M.- Lung epithelial Na+ channels are regulated by mechanical forces
     - Carbon monoxide rapidly impairs alveolar fluid clearance by inhibiting epithelial sodium channels
     - Tuesday, March 24, Hall 4Oral SessionAnion transportChairpersons: J. Deitmer (Kaiserslautern)A. Schwab (Mnster) Nicotine activates chloride channels in mouse tracheal epithelium
     - Xenopus laevis lung epithelia exhibit basolateral Cl- channels involved in transepithelial Cl- secretion and reabsorption
     - Carbon monoxide modulates the activity of sodium channels in the alveolar epithelium: A role for ENaC?
     - The P2X7 receptor plays an important role in purinergic signaling pathways in alveolar macrophages
    Fuller M.- Gap junction mediated control of endothelial vasomotor activity
    Funke F.- Neonatal brainstem is prone to the generation of spreading depression during severe hypoxia
     - H2O2-mediated modulation of cytosolic signaling and organelle function in rat hippocampus
    Furst J.- ICln-self interactions assessed by fluorescence resonance energy transfer (FRET)

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