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Acta Physiologica Congress

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Acta Physiologica 2009; Volume 195, Supplement 669
The 88th Annual Meeting of The German Physiological Society
3/22/2009-3/25/2009
Giessen, Germany

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    H
    Haas H. L.- Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone
    Habazettl H.- Inhaled nitric oxide improves left ventricular function and reduces infarct size during myocardial ischemia by the Robin Hood effect
     - Contribution of altered microvascular responses to orthostatic intolerance after simulated exposure to microgravity
    Haberberger R.- Sphingosine-1-phosphate (S1P) pathway for heat hyperalgesia in C57Bl6J mice
    Haegele M.- Effects of active or passive recovery between high-intensity cycling bouts on power output, lactate and pH time course
    Haerteis S.- Functional characterization of the -subunit of human ENaC
    Hafezi W.- Delivery of herpes simplex virus type 1 genome through the nuclear pore complex
    Hagele S.- Enhanced hypoxia susceptibility in hippocampal slices from a mouse model of Rett Syndrome
    Hagen S.- Sunday, March 22, Hall 4Oral SessionIntestinal transportChairpersons: M. Bleich (Kiel)G. Breves (Hannover) Gastric KNCQ1 channels provide luminal K+ to the H+/K+ ATPase, whereas Kir 4.1 channels are involved in secretory membrane recycling
    Hagen V.- Heterotetrameric olfactory CNG channels are activated by the ligand binding to the two CNGA2 subunits only
    Hagenacker T.- Myricetin-induced modulation of voltage activated calcium and potassium channel currents in sensory neurones of rat
    Hagos Y.- HIF-1 affects etoposide-resistance and MDR-1 efflux activity
     - Tuesday, March 24, Audimax, Poster Area APoster Session: Kidney IIModerators: A. Kurtz (Regensburg)T. Volk (Erlangen) Organic cation transporter mediated cytotoxicity of irinotecan and paclitaxel
    Hahn A.- Oxygen diffusion through different liquid layers with and without surfactant in a physical model
    Halaszovich C.- Comparison of the affinities of PI(4,5)P2-binding domains in living cells with the help of the voltage-controlled PI(4,5)P2-5-phosphatase Ci-VSP
    Hallermann S.- The LEM-domain protein MAN1 is required for presynaptic function at the drosophila neuromuscular junction
     - Bruchpilot filaments accelerate vesicle reloading at active zones
    Hamer S.- Glycogen synthase kinase 3-beta (GSK3) forms multiple protein complexes
    Hammock B.- sEH-deficiency attenuates neointima formation in the femoral artery cuff model of hyperlipidemic mice
    Hammond H. K.- Impaired urinary concentration abilityin mice lacking adenylyl cyclase 6
    Handwerker H. O.- Effects of local lidocaine application on conductive properties of human C-fibers
    Hanley P.- The molecular compass for macrophage chemotaxis
     - Single-cell caspase-3/7 imaging: P2X7 receptor activation triggers cell death
    Hannig M.- Tumor-induced angiogenesis analyzed in confrontation cultures of multicellular tumor spheroids and embryonic stem cell-derived embryoid bodies
     - Characterisation of the 5-lipoxygenase pathway and leukotriene receptors in differentiating mouse embryonic stem cell derived embryoid bodies
    Happel P.- Migrating oligodendrocyte precursor cell somata swell prior to dislocation
    Har K.- Unusual role of Kv2 channels in rat posterior cerebral small arteries
    Harfe B.- Monday, March 23, Hall 3Oral SessionEpitheliumChairpersons: K. Kunzelmann (Regensburg)H. Oberleithner (Mnster) Defective Ca2+ dependent chloride secretion by TMEM16A knockdown
    Harjes U.- Impact of prolyl-4-hydroxylase domain (PHD) enzyme 2 on cell motility and adhesion
    Harmel N.- Simultaneous capacitance and fluorescence detection of single vesicle exocytosis
     - Tuesday, March 24, Audimax, Poster Area EPoster Session: Transporters and channelsModerators: K. Benndorf (Jena)S. Grnder (Aachen) The increase in AMPA receptor surface expression by auxAMPARs critically depends on receptor conformation
     - A novel family of proteins that control trafficking and gating of AMPA receptors
     - AuxAMPARs promote surface expression of AMPA receptors by selective ER export
    Hartel F.- Inhibition of prolyl hydroxylase attenuates hypoxia-reoxygenation-induced injury in endothelial cells
     - Hypoxia-induced ATP release protects human endothelial cells against apoptosis via autocrine P2Y2 receptor-mediated MEK/ERK signaling
     - Activation of AMP-activated protein kinase protects endothelial barrier against reperfusion-induced failure
    Hartig W.- Functional and molecular analysis of glutamate receptors in human midbrain-derived neural precursor cells
    Hartmann J.- MGluR/TRPC3-mediated synaptic Ca2+ signaling in spiny dendrites of central neurons
    Hartmann M.- Regulation of guanylyl cyclase-A, the receptor for atrial natriuretic peptide, by alternative splicing
    Hartmann S.- Overexpressing somatodendritic A-type potassium channel subunits in hippocampal neurons
    Hasin T.- Monday, March 23, Hall 3Keynote Lecture IIITranscription factors and signal transduction inmyocardial hypertrophyChairpersons: G. Euler (Giessen)A. Gdecke (Dsseldorf) Basic leucine zipper (bZIP) transcription factors mediate atrial signaling and hypertrophy
    Hassoun H.- Oxygen diffusion through different liquid layers with and without surfactant in a physical model
    Hatzelmann A.- PDE2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1
    Hatzelmann T.- Functional expression of the apelin-12 receptor protein APJ in rat hypothalamic nuclei (PVN and MnPO) involved in body fluid homeostasis and temperature regulation
    Hauser B.- Gender and Toll-like receptor signaling affect cardiac function in hypertrophy
    Hausser M.- Dendritic computation
     - Imaging functional connectivity in the cerebella cortical ciruit
    Haussinger D.- Suicidal erythrocyte death associated with cholestasis
    Hawlitschek C.- Effects of antihypertensive therapy on the development of cardiac insufficiency and structural remodeling in aged hypertensive rats
    Hecker M.- Wall tension-induced signaling in endothelial cells
     - Fluid shear stress-induced expression of the human nos-3
     - Cyclic stretch-mediated tyrosine nitration of CD40 impairs CD40L-stimulated IL12p40 expression in HUVEC
    Heckmann M.- From active zones to synaptic networks
     - Bruchpilot filaments accelerate vesicle reloading at active zones
     - The LEM-domain protein MAN1 is required for presynaptic function at the drosophila neuromuscular junction
    Hefft S.- Monday, March 23, Audimax, Poster Area APoster Session: EpilepsyModerators: A. Draguhn (Heidelberg)S. Hefft (Freiburg) Effects of levetiracetam on principal cells and interneurons in hippocampal slices
    Heger J.- Signal transduction ofplatelet-derived growth factor BB action enhancing vasculogenesis of embryonic stem cells
     - Matrix metalloproteinases as repressors of hypertrophy in ventricular cardiomyocytes of rats
     - From risk to heart failure in mice: Identification of UCP-2 and biglycan as potential risk factors in the left ventricle leading to severe heart failure
     - Induction of diabetes like hyperfiltration in heterozygous eNOS mice overexpressing TGF-b1 does not depend on changes in the mRNA expression of fibrotic markers
     - ANT1-overexpression compensates TGF induced apoptosis via stabilization of the mitochondrial permeability transition pore
    Hegyi P.- Downregulation of Na+/H+ exchanger isoform 3 (NHE3) function, but not expression, in colonic mucosa of patients with ulcerative colitis may be related to loss of PDZK1 adaptor protein expression
    Heigele S.- Monday, March 23, Audimax, Poster Area APoster Session: EpilepsyModerators: A. Draguhn (Heidelberg)S. Hefft (Freiburg) Effects of levetiracetam on principal cells and interneurons in hippocampal slices
    Heil M.- Accelerated collateral vessel growth in CD73-/- mice after hindlimb ischemia revealed by in vivo 3D magnetic resonance angiography
    Heimrich B.- A novel family of proteins that control trafficking and gating of AMPA receptors
    Heinemann S. H.- Scorpion -toxin Tz1 switches between excitatory and depressant modes in a voltage- and use-dependent manner
     - Thiol-dependent modulation of human EAG1 potassium channels
     - Functional impact of the S6-RCK linker in BK channels
     - Modulatory function ofPI3K in mu-opioid inhibition of voltage-gated calcium channels in nociceptive neurons
     - A conserved splice variant of NaV1.8 voltage-gated sodium channel from human dorsal root ganglion neurons
     - Tuesday, March 24, Hall 4Oral SessionPotassium channelsChairpersons: R. Bhring (Hamburg)S. H. Heinemann (Jena) EAG genes in Danio rerio coding for functional potassium channels
    Heinemann U.- Neurometabolic coupling and oxygen demands during gamma oscillations in the hippocampus
     - Electrophysiological properties of AMPA receptor mediated currents in tumor cells
    Heitmann V.- Extracellular ATP reduces paracellular endothelial permeability via mechanical relaxation
    Heitzmann D.- Monday, March 23, Audimax, Poster Area BPoster Session: Neuroprotection and hypoxiaModerators: D. Katschinski (Gttingen)U. Schrder (Magdeburg) TASK2 potassium channels are important determinants for central respiratory adaptation to hypoxia
     - Expression and localization of the TASK K+ channels in adrenal glands
     - Monday, March 23, Hall 1Main SessionPhysiology and pathophysiology of K2P -channelsSymposium of the Working Group Heart and Circulation PhysiologyChairpersons: J. Daut (Marburg)R. Warth (Regensburg) Invalidation of TASK1 K+ channels disrupts adrenal gland zonation and mineralocorticoid homeostasis
    Heller R.- Investigating the interplay of NO and ROS during cardiomyocyte differentiation from mouse embryonic stem cells
    Henke G.- Monday, March 23, Audimax, Poster Area CPoster Session: Kidney IModerators: W. Neuhofer (Mnchen)W. H. Castrop (Regensburg) Renal function of PDK1 hypomorphic mice
     - Non-selective cation channel-mediated Ca2+-entry, modulation of calcium/calmodulin-dependent kinase II (CaMKII) and G2/M cell cycle arrest in irradiated K562 leukemia cells
    Henle T.- ACE-inhibiting peptides in hypoallergenic infant formulas lower blood pressure and induce cardiac remodeling in the SHR-model
    Hennig B.- Actions of the gasotransmitter H2S on ion transport across rat distal colon
    Hennig T.- Proteolytic fragmentation of laminin modulates endothelial proliferation and differentiation via induction of oxygen radical formation and anoikis
     - Elastase treatment induces v3 integrin dependent activation of focal adhesion complexes
    Henning H. A.- MGluR/TRPC3-mediated synaptic Ca2+ signaling in spiny dendrites of central neurons
    Hennings J. C.- Localization and regulation of the anion exchanger 3 (Slc4A3) in mouse kidney
    Henrion U.- Disruption of stimulation of glutamate receptors by a schizophrenia-associated kinase mutant
     - Long QT syndrome-associated mutations in the voltage sensor of IKs channels may favor early after depolarizations
     - Altered stress-dependent IKs channel trafficking in LQTS
    Herbsleb M.- Muscle activation patterns of selected ankle muscles in haemophilic patients during bipedal upright standing depending on Orthopaedic Joint Score
    Hercule H.- Novel interaction between P450 eicosanoidsandendothelial nitric oxide in thecontrol arterial tone in mice
    Herget U.- Rehabilitation program for cerebellar patients presenting postural ataxia
    Hertel F.- A FRET-based approach for optical recording of adenosine A1 receptor activation
    Hertel S.- Possible explanation of the contrasting effects of minocycline in experiments on mitochondria and in a clinical study
    Hescheler J.- Recombinant and native Cav2.3 E-type voltage-gated Ca2+ channels interact with the molecular chaperone Hsp70
     - From physiology to stem cell therapy
    Hess J.- Thrombin activates NOX1 involving Gi and Rac1 in pulmonary artery smooth muscle cells
     - PDE2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1
     - Expression of NADPH oxidase components during early mouse embryo development
    Hesse M.- Pregnancy induced cardiovascular adaptation in mouse
    Heusch G.- Sunday, March 22, Hall 1Plenary LectureCardiovascular PhysiologyChairperson: H. M. Piper (Dsseldorf) Coronary microembolization from bedside to bench and back to bedside
    Hidalgo P.- Cation binding by bacterial glutamate transporters characterized through equilibrium and stop flow tryptophane fluorescence
     - Sodium dependence of glutamate transport by a prokaryotic glutamate transporter
    Hieke B.- Control of ion transport by AMPK: Is it important?
    Hilber K.- Conformational stability of the domain IV S6 segment of the voltage-gated Na channel as assessed by single- and double mutant perturbation analysis
    Hilberg T.- Muscle activation patterns of selected ankle muscles in haemophilic patients during bipedal upright standing depending on Orthopaedic Joint Score
    Hildbrandt B.- H2O2-mediated modulation of cytosolic signaling and organelle function in rat hippocampus
    Hildebrandt A.- Cyclic stretch-mediated tyrosine nitration of CD40 impairs CD40L-stimulated IL12p40 expression in HUVEC
    Hildebrandt B.- Enhanced hypoxia susceptibility in hippocampal slices from a mouse model of Rett Syndrome
    Hille C.- Study of intracellular chloride homeostasis in cockroach salivary glands by using two-photon fluorescence lifetime imaging microscopy (2P-FLIM)
    Hillebrand I.- Myricetin-induced modulation of voltage activated calcium and potassium channel currents in sensory neurones of rat
    Himmerkus N.- Renal pathophysiology in mice deficient for the tetraspaninCD63/LIMP-1
     - Intestinal compensation mechanisms in mice with a collecting duct principal cell specific knockout of the mineralcorticoid receptor
     - Extracellular Ca2+ regulates paracellular permeability in the thick ascending limb of mouse kidney
    Hinrichs S.- Monday, March 23, Audimax, Poster Area DPoster Session: Regulation and myocardial metabolism and functionModerators: T. Noll (Giessen)H.-G. Zimmer (Leipzig) PPAR activation limits the nonenzymatic effect of renin on cell lengths in adult ventricular cardiomyocytes
    Hirdes W.- Erg K+ currents in gonadotropes
    Hitzel N.- Purinoceptor mediated signaling in neuronal and glial cells of the rat hypothalamic median preoptic nucleus
    Hocher B.- Endothelin receptor stimulation protects from suicidal erythrocyte death
    Hoffmann E.- Sphingosine-1-phosphate receptors stimulate macrophage plasma membrane actin assembly via ADP release, ATP synthesis and P2X7 receptor activation
    Hoffmann S.- Non secretory cytosolic renin protects cardiac cells from necrosis induced by glucose depletion or ischemia/reperfusion injury in the rat
    Hofmann A.- Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP
    Hofmann H.- Overexpressing somatodendritic A-type potassium channel subunits in hippocampal neurons
    Hofmann V. S.- Onconeuronal cerebellar degeneration-related antigen Cdr2 is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response
    Hogema B. M.- Sunday, March 22, Audimax, Poster Area BPoster SessionYoung Investigator Award (Poster):Channels and transportModerators: J. Daut (Marburg)J. Leipziger (Aarhus, DK) The PDZ proteins NHERF1 and NHERF2 have distinct roles in G-protein coupled receptor regulation of CFTR-mediated intestinal anion secretion in vivo
    Hollenhorst M.- Tuesday, March 24, Hall 4Oral SessionAnion transportChairpersons: J. Deitmer (Kaiserslautern)A. Schwab (Mnster) Nicotine activates chloride channels in mouse tracheal epithelium
    Hollmann M.- Disruption of stimulation of glutamate receptors by a schizophrenia-associated kinase mutant
    Holstein T. W.- The peptide-gated ion channel from Hydra magnipapillata is made of three homologous subunits
    Holthoff K.- Dendritic mechanisms of synaptic plasticity
    Holzer D.- Sphingosine-1-phosphate receptors stimulate macrophage plasma membrane actin assembly via ADP release, ATP synthesis and P2X7 receptor activation
    Holzherr B. D.- Tuesday, March 24, Hall 3Oral SessionCI? channels and non-selective cation channelsChairpersons: C. Fahlke (Hannover)K. Jurkat-Rott (Ulm) Cellular Na+ overload and K+-dependent depolarization indicate a nonselective cation leak
    Holzherr B.D.- hNav1.4 gating model with temperature dependence obtained from a coherent set of experimental data
    Holzinger H.- Inhibition of cyclooxygenases positively influences proximal tubular cell impairment in an in vitro model of renal ischemia and reperfusion.
    Hopfner M.- Novel antiangiogenic compounds for innovative treatment of renal cell carcinoma
    Hopp H.-H.- Effects of smooth muscle sensitized for light radiation with 5-aminolaevulinic acid and Bay K 8644
     - Biological network analysis in excitable tissues
    Hoppeler H.- Exercise dependent regulation of muscle plasticity
    Horth K.- Bile acids affect electrical activity and [Ca2+]c in pancreatic beta cells
    Hoshi T.- Functional impact of the S6-RCK linker in BK channels
     - Thiol-dependent modulation of human EAG1 potassium channels
    Hotzy J.- Anion-dependent conformational changes in glutamate transporters detected by fluorescence spectroscopy and voltage-clamp fluorometer
    Hou J.- Extracellular Ca2+ regulates paracellular permeability in the thick ascending limb of mouse kidney
    Hounker R.- Influence of otoplastics or hearing impairment on auditory evoked potentials, auditory evoked magnetic fields and source localization in professional musicians from classical orchestras
    Hoyer J.- Ca2+-dependent K+-channels (IK1, SK3) mediate arteriolar dilation in a distinct stimulus-dependent fashion
    Hrdina J.- Loss of mitochondrial thioredoxin reductase (TrxR-2) limits tumor growth
    Hrncic D.- L-NAME potentiate homocysteine-induced convulsions in adult rats
     - Pretreatment with L-arginine reverse redutionof brain Na+/K+ ATPase activity induced by homocysteine thiolactone in adult rats
    Hu H.- Propagation of action potentials in the dendrites of fast-spiking basket cells in the dentate gryus
     - Structural and functional properties of the dendritic cable in fast-spiking GABAergic interneurons
    Huang Y.- Novel interaction between P450 eicosanoidsandendothelial nitric oxide in thecontrol arterial tone in mice
    Huber K.- Dietary N supply modulates jejunal glucose absorption in goats
    Huber O.- Tuesday, March 24, Hall 4Oral SessionKidney PhysiologyChairpersons: M. Gekle (Halle/Saale),F. Schweda (Regensburg) Tricellulin enhances the barrier for ions and for macromolecules depending on its localization within the tight junction
    Huber R.- Tuesday, March 24, Hall 5Oral SessionEpithelial sodium channelsChairpersons: C. Korbmacher (Erlangen)K. Kusche-Vihrog (Mnster) Functional characterization of a loss-of-function mutation of human ENaC associated with atypical CF
    Huber S.- Effect of cyclosporine onparasitemia and survival of Plasmodium berghei-infected mice
     - Azathioprine favorably influences the course of malaria
     - Non-selective cation channel-mediated Ca2+-entry, modulation of calcium/calmodulin-dependent kinase II (CaMKII) and G2/M cell cycle arrest in irradiated K562 leukemia cells
    Hubner C. A.- Localization and regulation of the anion exchanger 3 (Slc4A3) in mouse kidney
    Hubricht J.- Downregulation of Na+/H+ exchanger isoform 3 (NHE3) function, but not expression, in colonic mucosa of patients with ulcerative colitis may be related to loss of PDZK1 adaptor protein expression
    Hubschle T.- Fever, sickness behavior and circulating cytokines in response to macrophage-activating lipopeptide-2 and lipopolysaccharide in toll-like receptor-2-deficient mice and CD36-deficient rats
    Huchzermeyer C.- Neurometabolic coupling and oxygen demands during gamma oscillations in the hippocampus
    Huebner A.- In vivo intramuscular electrical stimulation of rat triceps brachii with a multichannel electrode array
     - The back muscles of laboratory rats
    Hufnagl C.- The non-gastric H+/K+-ATPase ATP12A exerts an anti-apoptotic effect on butyrate-treated myelomonocytic HL60 cells
    Huggel K.- Human imino acid transporter SIT1 (SLC6A20) function is modulated by accessory proteins collectrin and ACE2
     - ACE2 and collectrin are tissue-specific associated proteins of the amino acid transporter B0AT1 and B0AT1-Hartnup-causing mutations
    Hulsmann S.- Visualisation of respiratory activity in breathing slices from mice using voltage-sensitive dyes
     - Activity-dependent currents recorded from astrocytes in the respiratory network
    Humberg J.- Regulation of human organic cation transporter 2 (hOCT2) by the new interacting partner lysosomal associated protein transmembrane 4 alpha (LAPTM4A)
    Hunger-Duda A.- Increasing conversion of AMP to adenosine by LPC and PAF is blocked by dihydrosphinganine
    Husse B.- Fibrosis mediated by aldosterone interaction with a second agonist in cultured fibroblasts of adult rat hearts
     - Direct interaction of mineralocorticoid receptor and EGF receptor

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