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Acta Physiologica Congress

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Acta Physiologica 2009; Volume 195, Supplement 669
The 88th Annual Meeting of The German Physiological Society
3/22/2009-3/25/2009
Giessen, Germany

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    da Costa Goncalvez A.- Novel interaction between P450 eicosanoidsandendothelial nitric oxide in thecontrol arterial tone in mice
    da Costa Rebelo R. M.- Monday, March 23, Audimax, Poster Area DPoster Session: Regulation and myocardial metabolism and functionModerators: T. Noll (Giessen)H.-G. Zimmer (Leipzig) PPAR activation limits the nonenzymatic effect of renin on cell lengths in adult ventricular cardiomyocytes
     - Monday, March 23, Audimax, Poster Area DPoster Session: Exercise under physiological andpathophysiological conditionsModerators: N. Maassen (Hannover)S. Rohrbach (Halle/Saale) The effect of exercise on cardiac physiology of hypertensive animals: Risk reduction or risk progression?
     - Physical exercise and hypertension: Risk or benefit?
    Da Silva-Azevedo L.- Possible atheroprotective effects of hyaluronic acid from the endothelial surface layer
    Da Tan C.- Monday, March 23, Hall 1Main SessionPhysiology and pathophysiology ofpulmonary epithelial ionJoint Symposium with the Excellence Cluster Cardiopulmonary System and SFB 547 Cardio-Pulmonary VasculatureChairpersons: W. Clauss (Giessen)R. E. Morty (Giessen) Regulation of Na+ transport by AMPK in human lung epithelial cells
    Dahlmann A.- Dual-specificity tyrosine phosphorylated and regulated kinase type 2 (DYRK2) activates the epithelial sodium channel (ENaC) in Xenopus laevis oocytes and in mouse distal nephron
    Daiber A.- Sunday, March 22, Hall 3Oral SessionPulmonary pathophysiology and hypoxiaChairpersons: D. M. Katschinski (Gttingen)H. Scholz (Berlin) Deletion of the subunit of the large conductance calcium-activated potassium channel abrogates epoxyeicosatrienoic acid-induced pulmonary vasoconstriction
    Damm J.- Spatiotemporal activation of the transcription factor NF-IL6 in the rat brain during systemic inflammation
    Daniel H.- Monday, March 23, Audimax, Poster Area EPoster Session: Gut and epithelial transporters IModerators: M. Ritter (Salzburg, AT)J. Roth (Giessen) Dual role of the Na+/H+ exchanger isoform 3 for PEPT1-mediated H+/dipeptide cotransport in native murine intestine
     - SGK1-dependent regulation of intestinal peptide transport
    Daniel J.-M.- Time course analysis of bone marrow derived progenitor cell transdifferentiation during neointima formation
     - Role of Sirt1 in vascular homeostasis and pathologic remodeling
    Danilczyk U.- ACE2 and collectrin are tissue-specific associated proteins of the amino acid transporter B0AT1 and B0AT1-Hartnup-causing mutations
    Darvas M.- Modulation of the Ca2+ conductance of nicotinic acetylcholine receptors by the endogenous protein Lypd6
    Datchev A.- Metabolic pathways regulate P-glycoprotein gene expression via reactive oxygen species
    Daut J.- Mutation of the critical histidine residue in the T1 domain of Kv2.1 prevents the heteromeric assembly of Kv2.1/Kv6.x channels
     - Identification of a C-terminal region causing intracellular retention of TASK-3 channels
     - TASK-1 channels in cardiac muscle cells of murine and human heart
     - The glycolytic enzymes GAPDH and enolase- serve as accessory proteins of the renal epithelial potassium channel hROMK-2 and regulate its function
    Dauwalder T.- Expression of the neutral amino acid transporter B0AT1 (Slc6a19) and its specific renal accessory protein collectrin in MDCK cell line
    David R.- Genetic or pharmacological CD26/DPP-IV inhibition combined with G-CSF administration enhances homing of stem cells and improves ventricular function after acute myocardial infarction
    De Col R.- New insights into the activity-dependent regulation of axonal conduction velocity
    de Marees M.- Differential influence of acute and chronic altitude training on apoptosis, proliferation and senescence of endothelial progenitor cells
    de Morree H.- Influence of a combined low-carbohydrate high intensity interval training intervention on insulin sensitivity, blood lipids and whole body metabolism in obese sedentary individuals
    de Wit C.- Tuesday, March 24, Hall 1Main SessionConnexins and gap junctions: Functional role in thevascular systemSymposium of the Working Group Heart and Circulation PhysiologyChairpersons: R. P. Brandes (Frankfurt a. M.)U. Pohl (Mnchen) Coordination of vasomotor responses along the vascular wall through gap junctions and connexins
    Decher N.- Tamm-Horsfall glycoprotein interacts with renal potassium channel ROMK2 and regulates its function
     - TASK-1 channels in cardiac muscle cells of murine and human heart
    Decking U.- What is the role of extracellular adenosine formation by ecto-5-nucleotidase (CD73) in ischemic preconditioning in the mouse heart?
    Deitmer J. W.- Carbonic anhydrase II supports lactate transport via monocarboxylate transporter isoform 4, but not via isoform 2
     - Enzymatic suppression of SNAT3-associated ion conductance by different carbonic anhydrase isoforms depend on the substrate
     - Functional interaction of carbonic anhydrase isoforms I, II and III with the electrogenic sodium-bicarbonate cotransporter NBCe1
    del Rey A.- Single-cell caspase-3/7 imaging: P2X7 receptor activation triggers cell death
    Delhasse Y.- Influence of focused and radial shock wave treatment on the behavior of human mesenchymal stem cells (MCSs)
    Derst C.- Mutation of the critical histidine residue in the T1 domain of Kv2.1 prevents the heteromeric assembly of Kv2.1/Kv6.x channels
    Desch M.- Human renin promoter cAMP response sequences are important for the cell-specific expression of renin in the adult kidney
     - Kidney-specific deficiency of PPAR results in increased mouse renin production
    Deussen A.- Complex regulation of inotropy, flow and NO/adenosine metabolism by platelet activating factor in mouse heart
     - Characterization of AMP-hydrolysis in human internal mammary artery
     - Increasing conversion of AMP to adenosine by LPC and PAF is blocked by dihydrosphinganine
     - Effect of omega-3-fatty acid DHA on the regulation of ecto-5-nucleotidase in endothelial cells
     - Sunday, March 22, Hall 2Oral SessionExtracellular nucleotides and ischemiaChairpersons: U. Decking (Dsseldorf)A. Deussen (Dresden) Mathematical modeling of the AMP conversion to adenosine in flow experiments with human internal mammary arteries
     - Improvement of vessel graft storage in a new preservation solution on human internal mammary artery (HIMA)
     - ACE-inhibiting peptides in hypoallergenic infant formulas lower blood pressure and induce cardiac remodeling in the SHR-model
    Dhein S.- Calcium-sensing receptor in the human heart
     - Is there any evidence for ephaptic coupling? A computer simulation study giving new insights
    D'hoedt D.- Towards a better understanding of SK channel physiology and pharmacology
    Di Virgilio F.- Single-cell caspase-3/7 imaging: P2X7 receptor activation triggers cell death
    Diakov A.- Tuesday, March 24, Hall 5Oral SessionEpithelial sodium channelsChairpersons: C. Korbmacher (Erlangen)K. Kusche-Vihrog (Mnster) Functional characterization of a loss-of-function mutation of human ENaC associated with atypical CF
     - Dual-specificity tyrosine phosphorylated and regulated kinase type 2 (DYRK2) activates the epithelial sodium channel (ENaC) in Xenopus laevis oocytes and in mouse distal nephron
    Diebold I.- PDE2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1
     - Thrombin activates NOX1 involving Gi and Rac1 in pulmonary artery smooth muscle cells
    Diehl A.- The effect of hyperglycaemia on the -adrenoceptor responsiveness in adult ventricular cardiomyocytes
    Diener M.- Carbon monoxide-induced anion secretion across rat distal colon
     - Actions of the gasotransmitter H2S on ion transport across rat distal colon
     - Characterization of bradykinin-induced effects in colonic submucosal neurons of the rat
     - Effects of H2O2 at rat myenteric neurones in culture
     - Involvement of cGMP-sensitive phosphodiesterases in the action of NO on rat myenteric neurons
    Dieterich P.- Monday, March 23, Hall 5Oral SessionCell migrationChairpersons: E. Schlatter (Mnster)H.-J. Schnittler (Dresden) The Na+/H+ exchanger NHE1 plays a central role in directional fibroblast migration stimulated via PDGFR signaling in the primary cilium
     - Analysis and quantification of cell migration during chemotaxis
     - Improvement of vessel graft storage in a new preservation solution on human internal mammary artery (HIMA)
     - Sunday, March 22, Hall 2Oral SessionExtracellular nucleotides and ischemiaChairpersons: U. Decking (Dsseldorf)A. Deussen (Dresden) Mathematical modeling of the AMP conversion to adenosine in flow experiments with human internal mammary arteries
    Dieterle A.- Upregulation of CGRP- and nNOS-immunoreactive neurons in the rat trigeminal ganglion after infusion of a NO donor
    Dietl P.- TRP channel modulators 2-aminoethoxydiphenyl borate and capsazepine induce clathrin dependent endocytosis in H441 cells
     - TRP channel blockers inhibit amiloride-sensitive whole cell currents in distal lung epithelia with higher potency than transepithelial shortcircuit currents
    Dietrich A.- The role of the Ca2+ channels TRPC1 and TRPC6 in neutrophil migration
     - TRPC1 suppresses the Ca2+ permeability in heteromeric channel complexes without effects on arterial tone
    Dietz G. P.- Recombinant and native Cav2.3 E-type voltage-gated Ca2+ channels interact with the molecular chaperone Hsp70
    Dietzel-Meyer I.- Upregulation of neuronal sodium current density in hippocampal neurons by thyroid hormone involves bFGF and glial cells
     - Migrating oligodendrocyte precursor cell somata swell prior to dislocation
    Dimitrova T.- Inhibition of prolyl hydroxylase attenuates hypoxia-reoxygenation-induced injury in endothelial cells
    Ding Z.- Accelerated atherosclerosis inapolipoprotein E/ecto-5nucleotidase (CD73) double-deficient mice
    Dinu C.- Erg K+ currents in gonadotropes
    Djordjevic T.- PDE2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1
    Djuric D.- Pretreatment with L-arginine reverse redutionof brain Na+/K+ ATPase activity induced by homocysteine thiolactone in adult rats
     - L-NAME potentiate homocysteine-induced convulsions in adult rats
    Dobler T.- The two-pore domain channel TRESK is the major component of potassium background current and a molecular target for plant ingredients in DRG neurons
    Domenighetti A.- Angiotensin II-mediated adaptive and maladaptive remodeling of cardiomyocyte excitation-contraction coupling
    Donowitz M.- Sunday, March 22, Audimax, Poster Area BPoster SessionYoung Investigator Award (Poster):Channels and transportModerators: J. Daut (Marburg)J. Leipziger (Aarhus, DK) The PDZ proteins NHERF1 and NHERF2 have distinct roles in G-protein coupled receptor regulation of CFTR-mediated intestinal anion secretion in vivo
    Doring F.- The two-pore domain channel TRESK is the major component of potassium background current and a molecular target for plant ingredients in DRG neurons
    Dorner A.- ANT1-overexpression compensates TGF induced apoptosis via stabilization of the mitochondrial permeability transition pore
    Dosche C.- Study of intracellular chloride homeostasis in cockroach salivary glands by using two-photon fluorescence lifetime imaging microscopy (2P-FLIM)
    Draguhn A.- Effects of glutamate uptake blockers on different forms of epileptiform activity in vitro
    Drews A.- Differentiation between homo- and heteromultimers of the ionotropic steroid receptors TRPM3 and TRPM1
     - The natural enantiomer of pregnenolone sulfate activates TRPM3 channels much stronger than its synthetic counterpart
    Drews G.- Altering AMPK activity affects pancreatic beta cell function
     - Limiting KATP channel activity leads to upregulation of antioxidant enzymes and protection of pancreatic beta cells against oxidative stress
     - Bile acids affect electrical activity and [Ca2+]c in pancreatic beta cells
    Dringenberg U.- NBCn1 (Slc4a7) is a major HCO3- importer in murine duodenum and essential for basal and stimulated HCO3- secretion in vivo
     - Monday, March 23, Audimax, Poster Area EPoster Session: Gut and epithelial transporters IModerators: M. Ritter (Salzburg, AT)J. Roth (Giessen) Dual role of the Na+/H+ exchanger isoform 3 for PEPT1-mediated H+/dipeptide cotransport in native murine intestine
     - Genetic deletion of NHE3, Slc26a6 (PAT1), Slc26a3 (DRA) and CFTR helps unravel the different pathways for duodenal HCO3- and H+ secretion in vivo
    Dubrovska G.- TRPC1 suppresses the Ca2+ permeability in heteromeric channel complexes without effects on arterial tone
    Dufer M.- Bile acids affect electrical activity and [Ca2+]c in pancreatic beta cells
     - Altering AMPK activity affects pancreatic beta cell function
     - Limiting KATP channel activity leads to upregulation of antioxidant enzymes and protection of pancreatic beta cells against oxidative stress
    Duhme N.- Wednesday, March 25, Hall 3Oral SessionRegulation of cardiac ion channelsChairpersons: H. Ehmke (Hamburg)L. Pott (Bochum) Functional analysis of two new HCN4 mutant channels with different clinical characteristics
    Duncker D.- Excercise in adverse remodeling
    Durrnagel S.- The peptide-gated ion channel from Hydra magnipapillata is made of three homologous subunits
    Dustin S.- Human imino acid transporter SIT1 (SLC6A20) function is modulated by accessory proteins collectrin and ACE2
    Duszenko M.- Long QT syndrome-associated mutations in the voltage sensor of IKs channels may favor early after depolarizations
    Dutschmann M.- Neonatal brainstem is prone to the generation of spreading depression during severe hypoxia
     - Hypoxia prolonged effects of the central cholinergic modulation of breathing after organophosphorus poisoning in the perfused brainstem preparation of rat

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