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Acta Physiologica Congress

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Acta Physiologica 2009; Volume 195, Supplement 669
The 88th Annual Meeting of The German Physiological Society
3/22/2009-3/25/2009
Giessen, Germany

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    L
    Ladilov Y.- Sodium-bicarbonate co-transporter SLC4A7 modulates the mitochondrial pathway of apoptosis in coronary cells under ischemic stress
    Lahn M.- Study of intracellular chloride homeostasis in cockroach salivary glands by using two-photon fluorescence lifetime imaging microscopy (2P-FLIM)
    Lalli E.- Monday, March 23, Hall 1Main SessionPhysiology and pathophysiology of K2P -channelsSymposium of the Working Group Heart and Circulation PhysiologyChairpersons: J. Daut (Marburg)R. Warth (Regensburg) Invalidation of TASK1 K+ channels disrupts adrenal gland zonation and mineralocorticoid homeostasis
     - The role of TASK3 potassium channel in the regulation of aldosterone secretion
    Lambert I. H.- HL-1mouse cardiomyocyte death after simulated ischemia and reperfusion is dependent on pHo: Roles of the Na+/H+ exchanger NHE1, and the Ca2+-independentphospholipase A2 PLA2-VI
    Lambert S.- The natural enantiomer of pregnenolone sulfate activates TRPM3 channels much stronger than its synthetic counterpart
     - Differentiation between homo- and heteromultimers of the ionotropic steroid receptors TRPM3 and TRPM1
    Lamle J.- Effect of genetic ablation of the acid/base transporters pNBC1, NHE1, NHE2, and Slc26a7, on gastric epithelial functions
    Lang C.- Effect of cyclosporine onparasitemia and survival of Plasmodium berghei-infected mice
    Lang F.- Effect of cyclosporine onparasitemia and survival of Plasmodium berghei-infected mice
     - Regulation of erythrocyte survival by AMP-activated protein kinase
     - SGK1 and PIKfyve in the regulation of the Ca2+ channel TRPV6
     - Non-selective cation channel-mediated Ca2+-entry, modulation of calcium/calmodulin-dependent kinase II (CaMKII) and G2/M cell cycle arrest in irradiated K562 leukemia cells
     - Involvement of phosphoinositide dependent kinase PDK1 in the regulation of channel activity in pancreatic beta cells by epinephrine
     - Involvement of PI3K/AKT pathway in the hypoglycemic effects of saponins from Helicteres isora
     - Blunted activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3
     - Ca2+-dependent functions in peptidoglycan-stimulated mouse dendritic cells
     - Regulation of calcium signaling in dendritic cells by 1,25-dihydroxyvitamin D3
     - Endothelin receptor stimulation protects from suicidal erythrocyte death
     - Role of APC in erythrocte survival
     - Colon tumors express functional membrane androgen receptors that trigger pro-apoptotic responses
     - Stimulation of the Na+-glucose cotransporter SGLT1 by AMP-activated protein kinase
     - SGK1-dependent downregulation of Foxo3a promotes growth of colon tumors
     - Decreased susceptibility of the PDK1 hypomorphic mouse to tumor growth upon chemical cancerogenesis
     - Disruption of stimulation of glutamate receptors by a schizophrenia-associated kinase mutant
     - Participation of leukotriene C4 in the regulation of suicidal erythrocyte death
     - Azathioprine favorably influences the course of malaria
     - Suicidal erythrocyte death associated with cholestasis
     - Regulation of the EAAT3 by PIKfyve
     - Parvovirus B19 protein NS1 inhibits Na+/H+ exchanger
     - SGK1-dependent regulation of intestinal peptide transport
     - Altered stress-dependent IKs channel trafficking in LQTS
     - Monday, March 23, Hall 5Oral SessionRenal transport IIChairpersons: J. Leipziger (Aarhus, DK)E. Schlatter (Mnster) Calciuria and phosphaturia in mice expressing PKB/SGK-resistant GSK
     - Effects of glucocorticoids on regulation of cytosolic Ca2+ activityin dendritic cells
     - Monday, March 23, Audimax, Poster Area CPoster Session: Kidney IModerators: W. Neuhofer (Mnchen)W. H. Castrop (Regensburg) Renal function of PDK1 hypomorphic mice
     - Hyperaldosteronism in Klotho-deficient mice
     - Responses to diuretic treatment of SGK1 knockout mice
     - Long QT syndrome-associated mutations in the voltage sensor of IKs channels may favor early after depolarizations
     - PIP5k2A-dependent regulation of the excitatory amino acid transporter EAAT3
     - PIKfyve-dependent regulation of the Cl- channel ClC-2
    Lang P.- Dynamic regulation of titin stiffness in the Z/I region of the sarcomere
    Lang P. A.- Parvovirus B19 protein NS1 inhibits Na+/H+ exchanger
    Lang U. E.- Regulation of the EAAT3 by PIKfyve
     - PIP5k2A-dependent regulation of the excitatory amino acid transporter EAAT3
    Lange S.- Signal transduction ofplatelet-derived growth factor BB action enhancing vasculogenesis of embryonic stem cells
    Lange T.- Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate background Ca2+ entry and muscle fatigue
    Langehanenberg P.- Atrial natriuretic peptide antagonizes the vasopressin mediated water permeability in inner medullary collecting duct cells via proteinkinase G
    Langelueddecke C.- The role of AMPK in the regulation of insulin secretion and proliferation in INS-1E rat insulinoma cells
     - Resveratrol inhibits stimulus-secretion-coupling and induces apoptosis in INS-1E rat insulinoma cells
    Langhorst H.- Characterization of the epithelial sodium channel delta subunit in human nasal epithelium
    Larkum M.- Martinotti interneurons control the generation of calcium spikes in layer 5 pyramidal dendrites in vivo
    Larsen L. E.- Long-term depression of pain perception in man affects peripheral receptive fields
    Laufer J.- PIKfyve-dependent regulation of the Cl- channel ClC-2
     - SGK1 and PIKfyve in the regulation of the Ca2+ channel TRPV6
     - Regulation of the EAAT3 by PIKfyve
    Laufer S.- Participation of leukotriene C4 in the regulation of suicidal erythrocyte death
    Lauritzen G.- pH-regulatory ion transport in MCF-7 breast cancer cells: Effects of truncated ErbB2 receptor expression on transporter expression and activity, and role in resistance to cisplatin-induced death
     - A N-terminally truncated ErbB2 receptor enhances migration of MCF-7 breast cancer cells: Roles of the Na+/H+ exchanger NHE1 and of cytoskeletal reorganization
    Lee W.-K.- Roles of oxidative stress, ceramide and calpains in heavy metal-induced cell death of cultured kidney proximal tubule cells
     - Role of ferroportin-1 (FPN-1) in renal iron (Fe) handling
    Lehmann-Horn F.- Amphotericin B induced cation leak in skeletal muscle membranes and its implications for familial hypokalemic periodic paralysis
     - Sunday, March 22, Hall 5Oral SessionSignaling in skeletal and smooth muscleChairpersons: K. Jurkat-Rott (Ulm)S. Wenzel (Giessen) Activation of the Na+/K+/2Cl--cotransporter in mammalian skeletal muscle
     - Tuesday, March 24, Hall 3Oral SessionCI? channels and non-selective cation channelsChairpersons: C. Fahlke (Hannover)K. Jurkat-Rott (Ulm) Cellular Na+ overload and K+-dependent depolarization indicate a nonselective cation leak
     - hNav1.4 gating model with temperature dependence obtained from a coherent set of experimental data
    Lehmenkuhler A.- Transient anoxic depolarization is unable to condition the brainstem of adult rats for spreading depression (SD)
    Le-Huu S.- Impact of prolyl-4-hydroxylase domain (PHD) enzyme 2 on cell motility and adhesion
     - HIF-1 affects etoposide-resistance and MDR-1 efflux activity
    Leier G.- Establishing mRNA transfection procedures for functional CFTR correction
    Leipold E.- Scorpion -toxin Tz1 switches between excitatory and depressant modes in a voltage- and use-dependent manner
     - A conserved splice variant of NaV1.8 voltage-gated sodium channel from human dorsal root ganglion neurons
    Leipziger J.- Hemolysis induced bya-hemolysin from Escherichia coli requires P2X and pannexin receptor activation
     - The molecular compass for macrophage chemotaxis
     - Impaired aldosterone responsiveness in corticosteroid binding gobulin deficient mice
     - Adrenaline-induced colonic K+ secretion is conducted via KCa1.1 (BK) channel: implications of a regulated ZERO splice variant
     - Characterizing the pathway for nucleotide-release in renal epithelia
    Leitner M. G.- Sphingosine-1-phosphate (S1P) pathway for heat hyperalgesia in C57Bl6J mice
    Leitner M.G.- The outer hair cell current Ik,n (KCNQ4) is modulated by the redox conditions
    Lenzen E.- Endurance exercise improves peroxiredoxin expression in erythrocytes of men suffering from type 2 diabetes
     - Effects of sodium bicarbonate ingestion on pH and lactate distribution in different blood compartments after short term high intensity exercise
     - Exercise alters MCT1-protein expression and exercise-induced translocation in erythrocytes of men suffering from non-insulin dependent type II-diabetes
     - Determination of lactate influx rates into erythrocytes after maximal exercise
    Lesage F.- Monday, March 23, Hall 1Main SessionPhysiology and pathophysiology of K2P -channelsSymposium of the Working Group Heart and Circulation PhysiologyChairpersons: J. Daut (Marburg)R. Warth (Regensburg) Invalidation of TASK1 K+ channels disrupts adrenal gland zonation and mineralocorticoid homeostasis
     - The role of TASK3 potassium channel in the regulation of aldosterone secretion
     - Expression and localization of the TASK K+ channels in adrenal glands
    Leuner A.- Impaired vascular function in small resistance arteries of LOX-1 overexpressing mice on high-fat diet
    Leung F. P.- Novel interaction between P450 eicosanoidsandendothelial nitric oxide in thecontrol arterial tone in mice
    Li L.- Mitochondrial biogenesis and PGC-1alpha deacetylation by physical activity: Intact leptin signaling is required
    Liashkovich I.- Caspases 3 and 9 pave the way for apoptosis through breakdown of the nuclear barrier
     - Delivery of herpes simplex virus type 1 genome through the nuclear pore complex
     - Endothelial cell stiffness explored by a combination of fluorescence and atomic force microscopy
    Lieberer E.- KCNJ10 potassium channels in the mouse distal nephron
    Liebner S.- sEH-deficiency attenuates neointima formation in the femoral artery cuff model of hyperlipidemic mice
    Limberg S.- TASK-1 channels in cardiac muscle cells of murine and human heart
    Lin J.-S.- Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone
    Lindecke A.- Accelerated atherosclerosis inapolipoprotein E/ecto-5nucleotidase (CD73) double-deficient mice
    Lindemann O.- Monday, March 23, Hall 4Oral SessionTRP channelsChairpersons: A. Cavali (Homburg/Saar)A. Schwab (Mnster) TRPC1 channels guide migrating cells in chemokine gradients
     - The role of the Ca2+ channels TRPC1 and TRPC6 in neutrophil migration
    Lindner R.- Regulation of the EAAT3 by PIKfyve
    Lindvig A.- Long-term depression of pain perception in man affects peripheral receptive fields
     - Long-term depression of pain perception in man affects peripheral receptive fields
    Linke W. A.- Dynamic regulation of titin stiffness in the Z/I region of the sarcomere
    Linn T.- Anti-inflammatory thalidomide improves islet grafts survival and functions in a xenogenic environment
    Lips K.- Tuesday, March 24, Hall 4Oral SessionAnion transportChairpersons: J. Deitmer (Kaiserslautern)A. Schwab (Mnster) Nicotine activates chloride channels in mouse tracheal epithelium
    List D.- Hypertrophic cardiomyopathy mutations R723G and R453C in the myosin head homain cause force enhancement by different mechanisms
    Littwitz C.- Overexpression of A1-adenosine receptors in rat atrial myocytes results in increased functional expression of Kir2 inward-rectifying K+ channels
     - Acetylcholine-activated GIRK current (IK(ACh)) provides a sensitive assay for autocrine production and action of extracellular adenosine in rat atrial myocytes in vitro
    Loh B.- Beta-adrenergic stimulation prevents inhibition of alveolar Na-transport in hypoxia
    Lohmann C.- Tuesday, March 24, Audimax, Poster Area GPoster Session: Vascular function and remodelingModerators: R. P. Brandes (Frankfurt a. M.)G. Siegel (Berlin) Diet-induced obesity increases plasma aldosterone and impairs endothelial function
    Loot A.- Angiotensin II impairs endothelial function through PYK2-dependent tyrosine phosphorylation and inactivation of eNOS
     - Interfering with the association of A kinase anchoring proteins (AKAPs) to PKA prevents the fluid shear stress induced phosphorylation of eNOS in endothelial cells
    Lopez Davila A.- Is contraction or relaxation of rabbit psoas myofibrils rate-limited by Ca2+-regulated switch of the troponin complex?
    Lorenz G.- Wednesday, March 25, Hall 4Oral SessionVascular inflammation: Clinical aspectsChairpersons: W. Franz (Mnchen)A. Grlach (Mnchen) The renin-angiotensin system as a primary cause in the pathophysiology of polyarteritis nodosa in rats
    Loser S.- Sensitization of afferent nerve fibers by TNF in normal rat knee can be prevented by etanercept, COX-inhibitors, and by inhibitors of the p38 kinase pathway
    Lubomirov L. T.- Ileal smooth muscle contractile activity of neonatal mice is less sensitive to cAMP/PKA than to cGMP/PKG signaling
     - Endothelium dependent modulation of phosphorylation of smooth muscle myosin phosphatase in brain vessels by the thromboxane A2 mimetic, U-46619
    Luft F. C.- Novel interaction between P450 eicosanoidsandendothelial nitric oxide in thecontrol arterial tone in mice
    Luheshi G. N.- Leptin modulates neuroinflammation and neutrophil recruitment into the brain of mice during severe LPS-induced systemic inflammation
     - Spatiotemporal activation of the transcription factor NF-IL6 in the rat brain during systemic inflammation
    Luhmann H.- Sunday, March 22, Audimax, Poster Area APoster SessionYoung Investigator Award (Poster)Cardiovascular systemModerators: K. Brixius (Kln)U. Decking (Dsseldorf) Protein based nanoparticles for the efficient delivery of genes into brain endothelial cells
     - Use dependent shifts in intracellular Cl- alter GABAergicactions in identified neurons of the immature neocortex
     - GABAergic networks in the developing cerebral cortex are activated by taurine
    Luik S.- Participation of leukotriene C4 in the regulation of suicidal erythrocyte death
    Lullmann-Rauch R.- Renal pathophysiology in mice deficient for the tetraspaninCD63/LIMP-1
    Lunnemann M.- Preserved abundance but functional dysregulation of Na+/H+ exchanger isoform NHE3 in the small and large intestine in CD45RBhigh transfer colitis mice with diarrhea
    Lupescu A.- Parvovirus B19 protein NS1 inhibits Na+/H+ exchanger
    Lutze P.- Monday, March 23, Audimax, Poster Area EPoster Session: Stem and progenitor cells and transcription factorsModerators: B. Fleischmann (Bonn)A. Sachinidis (Kln) Cytosolic exon(29)renin protects H9c2 cardiomyoblasts from necrosis induced by oxidative stress via beneficial effects on mitochondrial functions
    Luu V.-D.- Onconeuronal cerebellar degeneration-related antigen Cdr2 is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response
    Lysenko N.- Unusual role of Kv2 channels in rat posterior cerebral small arteries

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