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Acta Physiologica Congress

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Acta Physiologica 2009; Volume 195, Supplement 669
The 88th Annual Meeting of The German Physiological Society
3/22/2009-3/25/2009
Giessen, Germany

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    W
    Wagner A. H.- Cyclic stretch-mediated tyrosine nitration of CD40 impairs CD40L-stimulated IL12p40 expression in HUVEC
    Wagner C.- The multiple physiological functions of acid-sensing
     - Impaired renal blood flow autoregulation due to compromised tubuloglomerular feedback in mice lacking connexin 40
     - From frog to mouse: Identification of three putative novel transporters
     - Localization and regulation of the anion exchanger 3 (Slc4A3) in mouse kidney
     - Tuesday, March 24, Audimax, Poster Area CPoster Session: Gut and epithelial transporters IIModerators: S. Amasheh (Berlin)U. Seidler (Hannover) Expression and dietary modulation of intestinal phosphate cotransporters
     - ACE2 and collectrin are tissue-specific associated proteins of the amino acid transporter B0AT1 and B0AT1-Hartnup-causing mutations
     - Differential regulation of three renal phosphate transporters by parathyroid hormone (PTH)
    Wagner M.- Localisation of K+ channel subunits in lipid rafts and modulation of K+ currents by membrane cholesterol content in rat left ventricular myocytes
     - Use-dependent block of the transient outward K+ current in rat left ventricular myocytes by the anti-malarial drug primaquine
     - The antioxidant n-acetylcysteine reduces L-type Ca2+ current density and ameliorates hypertrophy in cardiomyocytes of rats with ascending aortic stenosis
    Wagner N.- The LEM-domain protein MAN1 is required for presynaptic function at the drosophila neuromuscular junction
    Wagner T. F.- The natural enantiomer of pregnenolone sulfate activates TRPM3 channels much stronger than its synthetic counterpart
     - Differentiation between homo- and heteromultimers of the ionotropic steroid receptors TRPM3 and TRPM1
    Wahl P.- Effects of active or passive recovery between high-intensity cycling bouts on power output, lactate and pH time course
     - Determination of lactate influx rates into erythrocytes after maximal exercise
     - Effects of different warm up intensities on lactate distribution in different blood compartments and power output
     - Effects of sodium bicarbonate ingestion on pH and lactate distribution in different blood compartments after short term high intensity exercise
    Waldegger S.- Tamm-Horsfall glycoprotein interacts with renal potassium channel ROMK2 and regulates its function
     - The glycolytic enzymes GAPDH and enolase- serve as accessory proteins of the renal epithelial potassium channel hROMK-2 and regulate its function
    Wallner S.- Monday, March 23, Audimax, Poster Area GPoster Session: Cell PhysiologyModerators: S. Frede (Essen)H. Scholz (Berlin) Cells can exchange miRNA through gap junctions
    Walte M.- Real-time monitoring of cell elasticity and cytoskeletal dynamics in living cells with atomic force microscopy
    Waltenberger J.- Cellular VEGF resistance as a novel pathophysiological concept
    Walter U.- Dysregulation of hypothalamic-pituitary-adrenal hormone secretion in SPRED2-deficient mice
    Walther J.- Influence of high-fat diet on murine vascular dynamics in LDLR knockout compared to C57BL/6 mice analyzed in vivo by Doppler Fourier Domain Optical Coherence Tomography
    Walther T.- Protective effect of the angiotensin metabolite angiotensin-(17) in experimental acute lung injury
    Walz B.- cAMP affects Ca2+ signaling in salivary glands of the blowfly Calliphora vicina
     - Excitatory actions and corresponding innervation patterns of GABA, tyramine and octopamine in the cockroach salivary gland complex
    Walzog B.- Monday, March 23, Hall 4Oral SessionVascular inflammation: Basic aspectsChairpersons: H.-J. Schnittler (Dresden)B. Walzog (Mnchen) The mammalian actin binding protein 1 (mAbp1) is required for firm arrest and intraluminal crawling of neutrophils during the acute inflammatory response
    Wang H.-V.- Endurance training in heterozygous ILK-deficient mice induces a hypertrophic cardiomyopathy
    Wang J.- NBCn1 (Slc4a7) is a major HCO3- importer in murine duodenum and essential for basal and stimulated HCO3- secretion in vivo
     - Monday, March 23, Audimax, Poster Area EPoster Session: Gut and epithelial transporters IModerators: M. Ritter (Salzburg, AT)J. Roth (Giessen) Dual role of the Na+/H+ exchanger isoform 3 for PEPT1-mediated H+/dipeptide cotransport in native murine intestine
    Wang K.- SGK1-dependent downregulation of Foxo3a promotes growth of colon tumors
     - Regulation of erythrocyte survival by AMP-activated protein kinase
     - Participation of leukotriene C4 in the regulation of suicidal erythrocyte death
    Wanka H.- Non secretory cytosolic renin protects cardiac cells from necrosis induced by glucose depletion or ischemia/reperfusion injury in the rat
     - Monday, March 23, Audimax, Poster Area EPoster Session: Stem and progenitor cells and transcription factorsModerators: B. Fleischmann (Bonn)A. Sachinidis (Kln) Cytosolic exon(29)renin protects H9c2 cardiomyoblasts from necrosis induced by oxidative stress via beneficial effects on mitochondrial functions
    Wanner C.- COX-inhibition restores renal organic anion transport and positively influences renal outcome in a rat model of ischemic acute kidney injury
    Wartenberg M.- Investigating the interplay of NO and ROS during cardiomyocyte differentiation from mouse embryonic stem cells
     - Signal transduction ofplatelet-derived growth factor BB action enhancing vasculogenesis of embryonic stem cells
     - Nox1, Nox2 and Nox4 are key regulators of mouse embryonic stem cell-derived cardiovascular differentiation
     - Stimulation of cardiomyogenesis of embryonic stem cells by nitric oxide downstream of AMPK and mTOR signalling pathways
     - Phosphoinositide 3-kinases (PI3Ks) control early steps of cardiovascular differentiation of mouse embryonic stem cells
     - Characterisation of the 5-lipoxygenase pathway and leukotriene receptors in differentiating mouse embryonic stem cell derived embryoid bodies
     - Tumor-induced angiogenesis analyzed in confrontation cultures of multicellular tumor spheroids and embryonic stem cell-derived embryoid bodies
     - Metabolic pathways regulate P-glycoprotein gene expression via reactive oxygen species
     - NAD(P)H oxidases are key regulators of cardiomyocyte differentiation from embryonic stem cells
    Warth R.- The role of TASK3 potassium channel in the regulation of aldosterone secretion
     - Monday, March 23, Audimax, Poster Area BPoster Session: Neuroprotection and hypoxiaModerators: D. Katschinski (Gttingen)U. Schrder (Magdeburg) TASK2 potassium channels are important determinants for central respiratory adaptation to hypoxia
     - KCNJ10 potassium channels in the mouse distal nephron
     - Expression and localization of the TASK K+ channels in adrenal glands
     - Monday, March 23, Hall 1Main SessionPhysiology and pathophysiology of K2P -channelsSymposium of the Working Group Heart and Circulation PhysiologyChairpersons: J. Daut (Marburg)R. Warth (Regensburg) Invalidation of TASK1 K+ channels disrupts adrenal gland zonation and mineralocorticoid homeostasis
    Waschke J.- Atrial natriuretic peptide stimulates microvascular endothelial permeability
    Wassmann H.- The effect of DC potential shifts associated with quenching thirst on neuronal network activities
    Weber A.- Expression and localization of the TASK K+ channels in adrenal glands
    Weber K.- Gait abnormalities as an indicator for pain or structural joint damage in antigen-induced arthritis of the rat
    Weber M.- The two-pore domain channel TRESK is the major component of potassium background current and a molecular target for plant ingredients in DRG neurons
    Weber M.-A.- Tuesday, March 24, Hall 3Oral SessionCI? channels and non-selective cation channelsChairpersons: C. Fahlke (Hannover)K. Jurkat-Rott (Ulm) Cellular Na+ overload and K+-dependent depolarization indicate a nonselective cation leak
    Weber T.- Tuesday, March 24, Audimax, Poster Area DPoster Session: Central homeostatic regulationModerators: H. Braun (Marburg)R. Gerstberger (Giessen) Activation of (non-)nitrergic hypothalamic MnPO neurons due to systemic thermal and osmoregulatory stimulations in the rat
    Weber W.-M.- Characterization of the epithelial sodium channel delta subunit in human nasal epithelium
     - Establishing mRNA transfection procedures for functional CFTR correction
    Webler A.- Cytochrome P450-derived metabolites of nitro-fatty acids are signaling molecules
    Wedemeyer J.- Downregulation of Na+/H+ exchanger isoform 3 (NHE3) function, but not expression, in colonic mucosa of patients with ulcerative colitis may be related to loss of PDZK1 adaptor protein expression
    Wegener J.- Extracellular ATP reduces paracellular endothelial permeability via mechanical relaxation
     - TGF-1-induced anchor sites in cell junctions detected by AFM
    Wegner F.- Functional and molecular analysis of glutamate receptors in human midbrain-derived neural precursor cells
     - Monday, March 23, Audimax, Poster Area FPoster Session: Potassium channelsModerators: R. Preisig-Mller (Marburg)J. R. Schwarz (Hamburg) Functional characterization of voltage-gated potassium channels in human neural progenitor cells
    Weiergraber M.- Recombinant and native Cav2.3 E-type voltage-gated Ca2+ channels interact with the molecular chaperone Hsp70
    Weil T.- Sunday, March 22, Audimax, Poster Area APoster SessionYoung Investigator Award (Poster)Cardiovascular systemModerators: K. Brixius (Kln)U. Decking (Dsseldorf) Protein based nanoparticles for the efficient delivery of genes into brain endothelial cells
    Weinman E. J.- Sunday, March 22, Audimax, Poster Area BPoster SessionYoung Investigator Award (Poster):Channels and transportModerators: J. Daut (Marburg)J. Leipziger (Aarhus, DK) The PDZ proteins NHERF1 and NHERF2 have distinct roles in G-protein coupled receptor regulation of CFTR-mediated intestinal anion secretion in vivo
    Weise A.- Enzymatic suppression of SNAT3-associated ion conductance by different carbonic anhydrase isoforms depend on the substrate
    Weiser N.- CFTR expression controls the paracellular permeability of bronchial epithelium
    Weissmann N.- The cytoskeletal protein paxillin is associated with pulmonary vascular remodeling
     - Chronic hypoxia-induced pulmonary hypertension and pulmonary vascular remodeling are linked to the downregulation of the soluble epoxide hydrolase
    Weller J.- Establishing mRNA transfection procedures for functional CFTR correction
    Welsch J.- Fever, sickness behavior and circulating cytokines in response to macrophage-activating lipopeptide-2 and lipopolysaccharide in toll-like receptor-2-deficient mice and CD36-deficient rats
    Welschoff J.- Tuesday, March 24, Hall 3Oral SessionEndothelial cell biology: NO, NADPH oxidaseChairpersons: H. Morawietz (Dresden)U. Pohl (Mnchen) The 2-adrenoceptor antagonist ICI 118,551 relaxes pulmonary arteries via a Gi/o protein-dependent NO release
    Welsh M.J.- The Acid-Sensing Ion Channel 1a confers pH-dependent Modulation of Excitability in Central Neurons
    Wemhoner K.- TASK-1 channels in cardiac muscle cells of murine and human heart
    Wemmie J.A.- The Acid-Sensing Ion Channel 1a confers pH-dependent Modulation of Excitability in Central Neurons
    Wendel M.- Characterization of AMP-hydrolysis in human internal mammary artery
     - Effect of omega-3-fatty acid DHA on the regulation of ecto-5-nucleotidase in endothelial cells
    Wenger R.- Onconeuronal cerebellar degeneration-related antigen Cdr2 is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response
    Wenzel D.- Tuesday, March 24, Hall 3Oral SessionEndothelial cell biology: NO, NADPH oxidaseChairpersons: H. Morawietz (Dresden)U. Pohl (Mnchen) The 2-adrenoceptor antagonist ICI 118,551 relaxes pulmonary arteries via a Gi/o protein-dependent NO release
     - Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP
    Wenzel S.- The effect of hyperglycaemia on the -adrenoceptor responsiveness in adult ventricular cardiomyocytes
     - From risk to heart failure in mice: Identification of UCP-2 and biglycan as potential risk factors in the left ventricle leading to severe heart failure
     - The arginine competition: eNOS deficiency and polyamine metabolism
     - Induction of diabetes like hyperfiltration in heterozygous eNOS mice overexpressing TGF-b1 does not depend on changes in the mRNA expression of fibrotic markers
     - Biglycan: A negative regulator of cardiac elastin expression in diabetic hearts
     - Comparable parcrine effects of human progenitor cells irrespectively of the donor's age
     - Enhanced paracrine effects of cardiac progenitor cells depending on the underlying cardiovascular disease of the donor
     - Extracellular matrix in cardiac remodeling
    Wess J.- Impact of M3 and M5 acetylcholine receptors on cholinergic dilatation of mesenteric arteries in genetically modified mice
    Wesselborg S.- Parvovirus B19 protein NS1 inhibits Na+/H+ exchanger
    Westphal J. K.- Tuesday, March 24, Hall 4Oral SessionKidney PhysiologyChairpersons: M. Gekle (Halle/Saale),F. Schweda (Regensburg) Tricellulin enhances the barrier for ions and for macromolecules depending on its localization within the tight junction
    Wetzker R.- Modulatory function ofPI3K in mu-opioid inhibition of voltage-gated calcium channels in nociceptive neurons
    Weyhersmuller A.- Bruchpilot filaments accelerate vesicle reloading at active zones
     - The LEM-domain protein MAN1 is required for presynaptic function at the drosophila neuromuscular junction
    Wichmann C.- Bruchpilot filaments accelerate vesicle reloading at active zones
    Wieland T.- Atrial (ANP) and B-type natriuretic peptides (BNP) stimulate endothelial matrix metalloproteinase secretion and postischemic endothelial regeneration
    Wienands J.- Monday, March 23, Hall 4Oral SessionVascular inflammation: Basic aspectsChairpersons: H.-J. Schnittler (Dresden)B. Walzog (Mnchen) The mammalian actin binding protein 1 (mAbp1) is required for firm arrest and intraluminal crawling of neutrophils during the acute inflammatory response
    Wilkens M.- Effect of 1,25-dihydroxyvitamin D3 on macromineral homoeostasis of sheep fed different levels of calcium
    Willadt S.- Facilitated exocytosis of synaptic vesicles lacking the sensor for Ca2+-dependent fusion
    Williamson M.- The peptide-gated ion channel from Hydra magnipapillata is made of three homologous subunits
    Willnov T.- Impaired aldosterone responsiveness in corticosteroid binding gobulin deficient mice
    Wilson S.- The role of SGK1 in the glucocorticoid-induced activation of the -Enacgene promoter
     - PI3K and the regulation of airway Na+ transport
    Wilting J.- Hypoxia-inducible factor-1 affects cardiac function during chronic pressure overload
    Winkler K.- Arteriosclerosis prophylaxis by Ginkgo biloba (EGb 761) in patients with metabolic syndrome
    Winning S.- Induction of endotoxin tolerance mimics HIF-1 knockout and effects monocyte-endothelial interaction
    Winter J.- Gender and Toll-like receptor signaling affect cardiac function in hypertrophy
    Wischmeyer E.- The two-pore domain channel TRESK is the major component of potassium background current and a molecular target for plant ingredients in DRG neurons
    Wisden W.- Expression and localization of the TASK K+ channels in adrenal glands
    Wissuwa B.- Investigating the interplay of NO and ROS during cardiomyocyte differentiation from mouse embryonic stem cells
    Wit C.- Ca2+-dependent K+-channels (IK1, SK3) mediate arteriolar dilation in a distinct stimulus-dependent fashion
     - Impaired renal blood flow autoregulation due to compromised tubuloglomerular feedback in mice lacking connexin 40
    Wittekindt O. H.- TRP channel modulators 2-aminoethoxydiphenyl borate and capsazepine induce clathrin dependent endocytosis in H441 cells
    Wittekindt O.H.- TRP channel blockers inhibit amiloride-sensitive whole cell currents in distal lung epithelia with higher potency than transepithelial shortcircuit currents
    Wiwel M.- pH-regulatory ion transport in MCF-7 breast cancer cells: Effects of truncated ErbB2 receptor expression on transporter expression and activity, and role in resistance to cisplatin-induced death
     - A N-terminally truncated ErbB2 receptor enhances migration of MCF-7 breast cancer cells: Roles of the Na+/H+ exchanger NHE1 and of cytoskeletal reorganization
    Wojtowicz A.- Wall tension-induced signaling in endothelial cells
    Wolff N. A.- Role of ferroportin-1 (FPN-1) in renal iron (Fe) handling
    Wolff S.- Tuesday, March 24, Audimax, Poster Area BPoster Session: Motor systemsModerators: F. P. Kolb (Mnchen)J. P. Kuhtz-Buschbeck (Kiel) Cortical representation of pelvic floor muscles - an fMRI study
    Wolfram S.- Role of Sirt1 in vascular homeostasis and pathologic remodeling
    Wong C.- Connexin 37: A modifier gene in atherosclerosis and thrombosis
    Worek F.- Distribution of acetylcholine receptor subtypes in the respiratory related areas of the rat brainstem
    Wottawa M.- Normoxic destabilization of ATF-4 depends on proteasomal degradation
    Wotzlaw C.- Regulation of cellular oxygen-sensor activity controlling hypoxia-dependent transcription in mammalian cells
     - The cellular activity of prolyl-hydroxylase 2 is upregulated by nitric oxide
    Wree A.- Metabolic adaptation of tumor-initiating cells is a key factor determining angiogenesis in a sarcoma allograft model
    Wuchert F.- LPS, MDP and FSL-1 induced cellular activation in rat area postrema microglial cells
     - The Organum Vasculosum Laminae Terminalis (OVLT) as a central nervous sensor for putative exogenous and endogenous pyrogens
    Wulf G.- Tuesday, March 24, Audimax, Poster Area APoster Session: Kidney IIModerators: A. Kurtz (Regensburg)T. Volk (Erlangen) Organic cation transporter mediated cytotoxicity of irinotecan and paclitaxel

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