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Acta Physiologica Congress

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Acta Physiologica 2009; Volume 195, Supplement 669
The 88th Annual Meeting of The German Physiological Society
3/22/2009-3/25/2009
Giessen, Germany

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    Paczulla A.- Amphotericin B induced cation leak in skeletal muscle membranes and its implications for familial hypokalemic periodic paralysis
     - Tuesday, March 24, Hall 3Oral SessionCI? channels and non-selective cation channelsChairpersons: C. Fahlke (Hannover)K. Jurkat-Rott (Ulm) Cellular Na+ overload and K+-dependent depolarization indicate a nonselective cation leak
    Padmasekar M.- Stimulation of cardiomyogenesis of embryonic stem cells by nitric oxide downstream of AMPK and mTOR signalling pathways
    Pagi K.- Involvement of PI3K/AKT pathway in the hypoglycemic effects of saponins from Helicteres isora
    Palmada M.- Regulation of the EAAT3 by PIKfyve
    Palme D.- Non-selective cation channel-mediated Ca2+-entry, modulation of calcium/calmodulin-dependent kinase II (CaMKII) and G2/M cell cycle arrest in irradiated K562 leukemia cells
    Pan R.- Mitochondrial biogenesis and PGC-1alpha deacetylation by physical activity: Intact leptin signaling is required
    Pape H.-C.- Wednesday, March 25, Hall 2Main SessionMathematical models in physiologyChairpersons: A. Deussen (Dresden)E.-J. Speckmann (Mnster) A thalamo-cortical neuronal network model targets absence epilepsy
    Parmentier R.- Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone
    Passier R.- Human embryonic stem cells as a model for cardiac development and disease
    Patejdl R.- Transversal coordination of spontaneous activity in smooth muscle
    Patel H.- Monday, March 23, Hall 1Main SessionPhysiology and pathophysiology ofpulmonary epithelial ionJoint Symposium with the Excellence Cluster Cardiopulmonary System and SFB 547 Cardio-Pulmonary VasculatureChairpersons: W. Clauss (Giessen)R. E. Morty (Giessen) Regulation of Na+ transport by AMPK in human lung epithelial cells
    Patzak A.- Impact of M3 and M5 acetylcholine receptors on cholinergic dilatation of mesenteric arteries in genetically modified mice
    Paulmichl M.- ICln-self interactions assessed by fluorescence resonance energy transfer (FRET)
    Paulsen O.- Spike timing-dependent synaptic plasticity in cortical circuits
    Pavenstadt H.- TGF-1-induced anchor sites in cell junctions detected by AFM
     - Cyclosporin A induced apoptosis in primary cultured inner medullary collecting duct cells correlates with increased TNF expression
     - Atrial natriuretic peptide antagonizes the vasopressin mediated water permeability in inner medullary collecting duct cells via proteinkinase G
     - Regulation of human organic cation transporter 2 (hOCT2) by the new interacting partner lysosomal associated protein transmembrane 4 alpha (LAPTM4A)
    Pawlak M.- Reduced perception of vibration and myofascial pain during strong aerobic exercise in man
    Pearce D.- Blunted activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3
    Pedarzani P.- Signaling domains involved in the modulation of excitability and firing properties of hippocampal pyramidal neurons
    Pedersen L.- Monday, March 23, Hall 5Oral SessionCell migrationChairpersons: E. Schlatter (Mnster)H.-J. Schnittler (Dresden) The Na+/H+ exchanger NHE1 plays a central role in directional fibroblast migration stimulated via PDGFR signaling in the primary cilium
    Pedersen S. F.- Monday, March 23, Hall 5Oral SessionCell migrationChairpersons: E. Schlatter (Mnster)H.-J. Schnittler (Dresden) The Na+/H+ exchanger NHE1 plays a central role in directional fibroblast migration stimulated via PDGFR signaling in the primary cilium
     - A N-terminally truncated ErbB2 receptor enhances migration of MCF-7 breast cancer cells: Roles of the Na+/H+ exchanger NHE1 and of cytoskeletal reorganization
     - HL-1mouse cardiomyocyte death after simulated ischemia and reperfusion is dependent on pHo: Roles of the Na+/H+ exchanger NHE1, and the Ca2+-independentphospholipase A2 PLA2-VI
     - pH-regulatory ion transport in MCF-7 breast cancer cells: Effects of truncated ErbB2 receptor expression on transporter expression and activity, and role in resistance to cisplatin-induced death
    Pedrazzini T.- Angiotensin II-mediated adaptive and maladaptive remodeling of cardiomyocyte excitation-contraction coupling
    Pelvan A.- Fluid shear stress-induced expression of the human nos-3
    Penninger J.- ACE2 and collectrin are tissue-specific associated proteins of the amino acid transporter B0AT1 and B0AT1-Hartnup-causing mutations
    Penton Ribas D.- The role of TASK3 potassium channel in the regulation of aldosterone secretion
    Penzel T.- Sunday, March 22, Hall 4Oral SessionAdaptive processes in sleep and exerciseChairpersons: M. E. Schlfke (Hagen)P. Wahl (Kln) Sleep stages modify the coupling of respiration and heartbeat
    Perisic T.- Loss of mitochondrial thioredoxin reductase (TrxR-2) limits tumor growth
    Perlewitz A.- Untranslated regionsof the ENaC subunit mRNA act as targets forregulatory binding proteins in kidney cell lines
    Perrotti N.- SGK1-dependent downregulation of Foxo3a promotes growth of colon tumors
    Persson P. B.- Tuesday, March 24, Audimax, Poster Area EPoster Session: Neural degeneration and agingModerators: D. Bsselberg (El Paso, US),M. Diener (Giessen) Fragile X mental retardation protein (FMRP) stimulates translation of the human achaete-scute homologue-1 (hASH1) mRNA
     - Untranslated regionsof the ENaC subunit mRNA act as targets forregulatory binding proteins in kidney cell lines
     - EazyClone: A user-friendly application for the development of cloning strategies
     - Seed based systematic discovery of specific transcription factor target genes
    Peters B.- Wednesday, March 25, Hall 4Oral SessionVascular inflammation: Clinical aspectsChairpersons: W. Franz (Mnchen)A. Grlach (Mnchen) The renin-angiotensin system as a primary cause in the pathophysiology of polyarteritis nodosa in rats
    Peters J.- Wednesday, March 25, Hall 4Oral SessionVascular inflammation: Clinical aspectsChairpersons: W. Franz (Mnchen)A. Grlach (Mnchen) The renin-angiotensin system as a primary cause in the pathophysiology of polyarteritis nodosa in rats
     - Non secretory cytosolic renin protects cardiac cells from necrosis induced by glucose depletion or ischemia/reperfusion injury in the rat
     - Amiloride potently lowers arterial pressure in Cyp1a1ren-2 transgenic rats without significant effects on small artery function
     - Monday, March 23, Audimax, Poster Area EPoster Session: Stem and progenitor cells and transcription factorsModerators: B. Fleischmann (Bonn)A. Sachinidis (Kln) Cytosolic exon(29)renin protects H9c2 cardiomyoblasts from necrosis induced by oxidative stress via beneficial effects on mitochondrial functions
    Peters S. C.- Mitochondrial ROS initiate reoxygenation-induced calcium overload in cardiac endothelial cells
    Petersen M.- NGF induces long-term changes in axonal excitability of mechano-insensitive C-afferents in pig skin, in vivo
    Petry A.- Thrombin activates NOX1 involving Gi and Rac1 in pulmonary artery smooth muscle cells
     - PDE2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1
    Pexa A.- Accelerated atherosclerosis inapolipoprotein E/ecto-5nucleotidase (CD73) double-deficient mice
    Peyronnet-Roux J.- Monday, March 23, Audimax, Poster Area BPoster Session: Neuroprotection and hypoxiaModerators: D. Katschinski (Gttingen)U. Schrder (Magdeburg) TASK2 potassium channels are important determinants for central respiratory adaptation to hypoxia
    Pfannmuller B.- Calcium-sensing receptor in the human heart
    Pfeifer A.- Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP
    Pfeiffer N.- Impact of M3 and M5 acetylcholine receptors on cholinergic dilatation of mesenteric arteries in genetically modified mice
    Pfitzer G.- Ileal smooth muscle contractile activity of neonatal mice is less sensitive to cAMP/PKA than to cGMP/PKG signaling
     - Endothelium dependent modulation of phosphorylation of smooth muscle myosin phosphatase in brain vessels by the thromboxane A2 mimetic, U-46619
     - Is contraction or relaxation of rabbit psoas myofibrils rate-limited by Ca2+-regulated switch of the troponin complex?
     - The impact of the FHC-associated mutation K183 of troponin I on the Ca2+-transients of cardiomyocytes
    Philipp M.- TRPC1 suppresses the Ca2+ permeability in heteromeric channel complexes without effects on arterial tone
    Philipp S.- Modulation of TRPC4 channels by calcium and via calmodulin-binding sites
     - Differentiation between homo- and heteromultimers of the ionotropic steroid receptors TRPM3 and TRPM1
     - The natural enantiomer of pregnenolone sulfate activates TRPM3 channels much stronger than its synthetic counterpart
    Picard N.- Differential regulation of three renal phosphate transporters by parathyroid hormone (PTH)
     - Tuesday, March 24, Audimax, Poster Area CPoster Session: Gut and epithelial transporters IIModerators: S. Amasheh (Berlin)U. Seidler (Hannover) Expression and dietary modulation of intestinal phosphate cotransporters
    Pichler B. J.- Monday, March 23, Hall 5Oral SessionRenal transport IIChairpersons: J. Leipziger (Aarhus, DK)E. Schlatter (Mnster) Calciuria and phosphaturia in mice expressing PKB/SGK-resistant GSK
    Pinyazhko R.- Role of the nitrosative stress (NS) in the resistance of the esophageal epithelial barrier (EEB) in the experimental nonerosive damages
    Piper H. M.- Stimulation of cardiomyogenesis of embryonic stem cells by nitric oxide downstream of AMPK and mTOR signalling pathways
     - Matrix metalloproteinases as repressors of hypertrophy in ventricular cardiomyocytes of rats
     - Signal transduction ofplatelet-derived growth factor BB action enhancing vasculogenesis of embryonic stem cells
     - The role of cellular pH and mitochondrial permeability transition pore (MPTP) in postconditioning-mediated protection against acute myocardial reperfusion injury
     - Mitochondrial ROS initiate reoxygenation-induced calcium overload in cardiac endothelial cells
     - Sunday, March 22, Hall 5Oral SessionCalcium signaling and calcium storesChairpersons: Y. Abdallah (Giessen)H. Sauer (Giessen) Ca2+-induced necrosis in human astrocytes after cerebral hemorrhage
     - Hypoxia-induced ATP release protects human endothelial cells against apoptosis via autocrine P2Y2 receptor-mediated MEK/ERK signaling
     - Cannabinoid receptor activation protects coronary endothelium against reperfusion injury in a cellular model of ischemia and reperfusion
     - Activation of AMP-activated protein kinase protects endothelial barrier against reperfusion-induced failure
     - Tuesday, March 24, Audimax, Poster Area CPoster Session: Cardiovascular pathophysiologyModerators: B. F. Becker (Mnchen)H.-G. Zimmer (Leipzig) The role of cytosolic Ca2+-oscillations for inflammation in human cerebrovascular endothelial cells after subarachnoid hemorrhage
     - Wednesday, 25 March, Hall 3Oral SessionSarcomeric and mitochondrial function in cardiac andskeletal muscleChairpersons: K. Boengler (Essen)T. Kraft (Hannover) Protection of cardiac myocytes against reperfusion injury through inhibition of glycogen synthase kinase-3 (GSK-3) involves the mitochondrial permeability transition pore (MPTP)
     - ANT1-overexpression compensates TGF induced apoptosis via stabilization of the mitochondrial permeability transition pore
    Platen P.- eNOS patterns in human erythrocytes are regulated by physical exercise
    Platzer M.- A conserved splice variant of NaV1.8 voltage-gated sodium channel from human dorsal root ganglion neurons
    Plesnila N.- Inhaled nitric oxide improves left ventricular function and reduces infarct size during myocardial ischemia by the Robin Hood effect
    Plomer M.- From physics to physiology - transfer of knowledge within a practical course in physics
    Pogoda K.- Monday, March 23, Audimax, Poster Area GPoster Session: Cell PhysiologyModerators: S. Frede (Essen)H. Scholz (Berlin) Cells can exchange miRNA through gap junctions
     - A gap junction independent role of Cx43 in the control of migration of HeLa cells
     - Connexin 43 interacts with cortactin and enhances the migration of HeLa cells.
    Pohl U.- Connexin 43 interacts with cortactin and enhances the migration of HeLa cells.
     - A gap junction independent role of Cx43 in the control of migration of HeLa cells
     - Monday, March 23, Audimax, Poster Area GPoster Session: Cell PhysiologyModerators: S. Frede (Essen)H. Scholz (Berlin) Cells can exchange miRNA through gap junctions
     - Monday, March 23, Hall 4Oral SessionVascular smooth muscle tone and vascular remodelingChairpersons: M. Hecker (Heidelberg)M. Kuhn (Wrzburg) Activation of the AMP-activated protein kinase by A769662 induces dilation in hamster microvessels
     - Proteolytic fragmentation of laminin modulates endothelial proliferation and differentiation via induction of oxygen radical formation and anoikis
     - Gap junction mediated control of endothelial vasomotor activity
     - Elastase treatment induces v3 integrin dependent activation of focal adhesion complexes
    Poole S.- Leptin modulates neuroinflammation and neutrophil recruitment into the brain of mice during severe LPS-induced systemic inflammation
    Porten S.- eNOS patterns in human erythrocytes are regulated by physical exercise
    Pos K.- ACE2 and collectrin are tissue-specific associated proteins of the amino acid transporter B0AT1 and B0AT1-Hartnup-causing mutations
    Postnova S.- A mathematical model of hypothalamic regulation of sleep-wake cycles: Role of hypocretin/orexin
     - A computer modeling study of neuronal sensitivity and synchronization at tonic-to-bursting transitions
    Poteser M.- Calcium-dependent translocation of TRPC3 channels to the sarcolemma of mouse skeletal muscle fibres
    Pott L.- Downregulation of GIRK subunits by RNA-interference in rat atrial myocytes reveals transcriptional coupling of Kir3.1 and Kir3.4
     - Analysis of GIRK current desensitization using FRET
     - Acetylcholine-activated GIRK current (IK(ACh)) provides a sensitive assay for autocrine production and action of extracellular adenosine in rat atrial myocytes in vitro
     - A FRET-based approach for optical recording of adenosine A1 receptor activation
     - Overexpression of A1-adenosine receptors in rat atrial myocytes results in increased functional expression of Kir2 inward-rectifying K+ channels
    Poulsen K. A.- HL-1mouse cardiomyocyte death after simulated ischemia and reperfusion is dependent on pHo: Roles of the Na+/H+ exchanger NHE1, and the Ca2+-independentphospholipase A2 PLA2-VI
    Pouokam E.- Effects of H2O2 at rat myenteric neurones in culture
    Powell A. D.- Monday, March 23, Hall 2Keynote Lecture IINetwork synchronizationChairpersons: J. Bischofberger (Freiburg)O. A. Sergeeva (Dsseldorf) Network synchronisation in the brain in health and disease
    Praetorius H. A.- Characterizing the pathway for nucleotide-release in renal epithelia
     - Impaired aldosterone responsiveness in corticosteroid binding gobulin deficient mice
     - Adrenaline-induced colonic K+ secretion is conducted via KCa1.1 (BK) channel: implications of a regulated ZERO splice variant
     - Hemolysis induced bya-hemolysin from Escherichia coli requires P2X and pannexin receptor activation
    Praetorius J.- NBCn1 (Slc4a7) is a major HCO3- importer in murine duodenum and essential for basal and stimulated HCO3- secretion in vivo
    Preisig-Muller R.- Mutation of the critical histidine residue in the T1 domain of Kv2.1 prevents the heteromeric assembly of Kv2.1/Kv6.x channels
     - Identification of a C-terminal region causing intracellular retention of TASK-3 channels
     - The glycolytic enzymes GAPDH and enolase- serve as accessory proteins of the renal epithelial potassium channel hROMK-2 and regulate its function
    Preissner K. T.- Role of extracellular RNA on vascular permeability, edema formation and myocardial infarction size
    Preissner R.- Novel antiangiogenic compounds for innovative treatment of renal cell carcinoma
    Pries A. R.- Novel antiangiogenic compounds for innovative treatment of renal cell carcinoma
     - Possible atheroprotective effects of hyaluronic acid from the endothelial surface layer
     - Contribution of altered microvascular responses to orthostatic intolerance after simulated exposure to microgravity
    Prinzen F. W.- Is stretch mediated hypertrophy mediated by hormonal or autocrine factors?
    Pritschow B.- Inhibition of OAG-induced Ca2+ transients in TRPC6 transfected HEK 293 cells by the protein kinase inhibitor ML-9
     - Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate background Ca2+ entry and muscle fatigue
    Prock A.- miRNA-dependent regulation of smooth muscle cell function during neointima formation
     - The regulator of G protein signaling 5 (RGS5) prevents cell cycle entry and proliferation of smooth muscle cells and attenuates neointima formation
    Protzel C.- Superoxide formation in human intrarenal arteries is mainly due to NADPH oxidase activity and contributes to endothelium-dependent vasodilation
    Puta C.- Muscle activation patterns of selected ankle muscles in haemophilic patients during bipedal upright standing depending on Orthopaedic Joint Score
    Putz S.- Ileal smooth muscle contractile activity of neonatal mice is less sensitive to cAMP/PKA than to cGMP/PKG signaling

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