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Acta Physiologica 2009; Volume 195, Supplement 669
The 88th Annual Meeting of The German Physiological Society
3/22/2009-3/25/2009
Giessen, Germany
A NOVEL FAMILY OF PROTEINS THAT CONTROL TRAFFICKING AND GATING OF AMPA RECEPTORS
Abstract number: O533
Schwenk1 J., Harmel1 N., Zolles1 G., Bildl1 W., Heimrich2 B., Chisaka3 O., Jonas4 P., Schulte5 U., Fakler1 B., Klocker1 N.
1Department of Physiology II, University of Freiburg, Freiburg
2Department of Neuroanatomy, University of Freiburg, Freiburg
3Department of Cell and Developmental Biology, Kyoro University, Kyoto, Japan
4Department of Physiology I, University of Freiburg, Freiburg
5Logopharm GmbH, Freiburg
Glutamate receptors of the AMPA subtype (AMPARs) together with the transmembrane AMPAR-regulating proteins (TARPs) are widely accepted to mediate fast excitatory synaptic transmission in the mammalian brain. Here, we show by proteomic analysis that the majority of AMPARs in the rat brain are co-assembled with isoforms of a novel family of transmembrane proteins, referred to as auxiliary AMPAR subunits (auxAMPARs). Functionally, auxAMPARs promote surface expression and profoundly alter channel gating by slowing deactivation and desensitization kinetics. These results introduce a novel auxiliary subunit of native AMPAR complexes providing a novel molecular determinant for modulating excitatory neurotransmission in the CNS.
This work was supported by grants of the Deutsche Forschungsgemeinschaft to B.F. (SFB 746/TP16, SFB780/TPA3,GRK843, EXC 294) and to N.K. (SFB780/TPB4)
To cite this abstract, please use the following information:
Acta Physiologica 2009; Volume 195, Supplement 669 :O533