Principles of Gene Manipultation: An Introduction to Genetic Engineering
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As part of the website for the sixth edition of 'Principles of Gene Manipulation', we would like to introduce you to a range of exciting developments or new topics in the field of gene manipulation since the publication of the text in January 2002.

These pages will be updated at regular intervals, and will also include supplementary material and information for our sister text, 'Principles of Genome Analysis and Genomics, 3rd Edition', due for publication in September 2002.

This long-awaited sixth edition of a classic introductory textbook on gene manipulation has been substantially updated and revised to incorporate emerging technologies.

one of the most rapidly growing fields of study within science
provides coverage of a wider range of topics whilst maintaining the distinctive approach and organization of the previous edition
new chapters on genome-associated techniques and expression analysis have been added to the new edition

Principles of Gene Manipulation provides an excellent introduction to the area of gene manipulation for advanced level undergraduates with a basic grounding in genetics. Following the first chapter, which gives a general introduction to the text, chapters two to six provide the reader with the basic biology needed to understand this topic area. Chapters seven to thirteen are designed to be stand-alone topics which students can dip into depending on their course structure, thus extending the knowledge of a given subject and building upon the groundwork established in the first set of chapters. Finally, Chapter 14 aims to apply the topic of gene manipulation to a commercial context, exploring the applications of this technology.


Sandy B Primrose was an academic for 10 years and a senior manager in the biotechnology industry for 20 years. He now manages a consultancy practice focussed on technology management.

Richard M Twyman obtained a first class degree in genetics at the University of Newcastle upon Tyne in 1992 and a PhD in molecular biology at the University of Warwick in 1995. He has worked as a post-doctoral fellow at the MRC Laboratory of Molecular Biology in Cambridge and as a scientific writer at the John Innes Centre in Norwich. He is currently a Visiting Fellow at the Department of Biology, University of York, and a freelance scientific writer and teacher.

Robert W Old studied genetics at Cambridge University and obtained his doctorate in the Department of Molecular Biology at Edinburgh. He currently lectures at the University of Warwick where his principal research interests include the regulation of gene expression in Xenopus development.

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New Edition of Principles of Genome Analysis and Genomics