By Sandy B Primrose & Richard M Twyman

ISBN 1405101202
September 2002
320 pages
136 illustrations

Genome analysis and genomics are at the forefront of current research in the life sciences. Since the first edition of Principles of Genome Analysis, the sequencing of genomes has continued apace with the major landmark of the human genome sequence being achieved in 2001. Now the emphasis of biological research is on genomics: the understanding of gene function and the interaction of gene products at the whole genome level.

As before, this book provides a step-by-step outline of the techniques involved in genome mapping and sequencing. However, the text has now been greatly expanded to cover genomics and its sub-disciplines. Sections on genome sequencing and bioinformatics have been extensively revised and new chapters have been included which cover comparative genomics, functional genomics and proteomics. The book concludes with an exciting new chapter describing a variety of ways to utilize genome analysis and sequencing in biology, medicine and agriculture.

Aimed at advanced undergraduates, this text will follow the same format as the highly successful Principles of Gene Manipulation by Sandy B Primrose, Richard M Twyman and Robert W Old, now in its sixth edition.

• Completely revised new edition of an established textbook
• Featuring new chapters and examples from exciting new research in genomics, including the human genome project
• Excellent new co-author in Richard Twyman, also co-author of the new edition of hugely popular Principles of Gene Manipulation

Contents list

Preface, vii
Abbreviations
1 Setting the scene: the new science of genomics
2 The organization and structure of genomes
3 Subdividing the genome
4 Assembling a physical map of the genome
5 Sequencing methods and strategies
6 Genome annotation and bioinformatics
7 Comparative genomics
8 Protein structural genomics
9 Global expression profiling
10 Comprehensive mutant libraries
11 Mapping protein interactions
12 Applications of genome analysis and genomics
References
Index

Reviews

Dr David Burt, Roslin Institute, Edinburgh

" past editions appear to be successful and I certainly would buy the new updated edition"

"it will certainly be of use to advanced undergraduates and post-graduates"