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Acta Physiologica Congress

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Acta Physiologica 2009; Volume 195, Supplement 669
The 88th Annual Meeting of The German Physiological Society
3/22/2009-3/25/2009
Giessen, Germany

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    R
    Raciti D.- From frog to mouse: Identification of three putative novel transporters
    Racz I.- Modulation of the Ca2+ conductance of nicotinic acetylcholine receptors by the endogenous protein Lypd6
    Raddatz D.- Downregulation of Na+/H+ exchanger isoform 3 (NHE3) function, but not expression, in colonic mucosa of patients with ulcerative colitis may be related to loss of PDZK1 adaptor protein expression
    Radhakrishnan K.- Recombinant and native Cav2.3 E-type voltage-gated Ca2+ channels interact with the molecular chaperone Hsp70
    Radosavljevic T.- L-NAME potentiate homocysteine-induced convulsions in adult rats
    Rafalzik S.- The Organum Vasculosum Laminae Terminalis (OVLT) as a central nervous sensor for putative exogenous and endogenous pyrogens
     - LPS, MDP and FSL-1 induced cellular activation in rat area postrema microglial cells
    Raha S.- Resveratrol targets key survival gene hsp70 and induces apoptosis in chronic myeloid leukaemia
    Rahimi R.- Effect of different rest intervals during resistance training on growth hormone, testosterone and blood lactate
    Rakonczay Z.- Downregulation of Na+/H+ exchanger isoform 3 (NHE3) function, but not expression, in colonic mucosa of patients with ulcerative colitis may be related to loss of PDZK1 adaptor protein expression
    Ramadan T.- Expression of the neutral amino acid transporter B0AT1 (Slc6a19) and its specific renal accessory protein collectrin in MDCK cell line
    Randriamboavonjy V.- Cytochrome P450-derived metabolites of nitro-fatty acids are signaling molecules
    Rangelov G.- From physics to physiology - transfer of knowledge within a practical course in physics
    Raquel Martins J.- Tuesday, March 24, Audimax, Poster Area FPoster Session: LungModerators: K. Kunzelmann (Regensburg)H. Schillers (Mnster) ER localized and Pak2 phosphorylated bestrophin 1 confers receptor activation of epithelial Ca2+ dependet ion channels
    Rasic - Markovic A.- L-NAME potentiate homocysteine-induced convulsions in adult rats
     - Pretreatment with L-arginine reverse redutionof brain Na+/K+ ATPase activity induced by homocysteine thiolactone in adult rats
    Rassler B.- Effects of antihypertensive therapy on the development of cardiac insufficiency and structural remodeling in aged hypertensive rats
    Rauen U.- Improvement of vessel graft storage in a new preservation solution on human internal mammary artery (HIMA)
    Rauh R.- Functional characterization of the -subunit of human ENaC
     - Tuesday, March 24, Hall 5Oral SessionEpithelial sodium channelsChairpersons: C. Korbmacher (Erlangen)K. Kusche-Vihrog (Mnster) Functional characterization of a loss-of-function mutation of human ENaC associated with atypical CF
    Raupach A.- Tuesday, March 24, Audimax, Poster Area APoster Session: Ca? and energy homeostasisModerators: U. Flgel (Dsseldorf)K.-D. Schlter (Giessen) HL-1 cardiomyocytes display isoform-specific functions of Akt1 and Akt2
    Rausch B.- Sunday, March 22, Audimax, Poster Area BPoster SessionYoung Investigator Award (Poster):Channels and transportModerators: J. Daut (Marburg)J. Leipziger (Aarhus, DK) The PDZ proteins NHERF1 and NHERF2 have distinct roles in G-protein coupled receptor regulation of CFTR-mediated intestinal anion secretion in vivo
     - Genetic deletion of NHE3, Slc26a6 (PAT1), Slc26a3 (DRA) and CFTR helps unravel the different pathways for duodenal HCO3- and H+ secretion in vivo
     - NBCn1 (Slc4a7) is a major HCO3- importer in murine duodenum and essential for basal and stimulated HCO3- secretion in vivo
     - Effect of genetic ablation of the acid/base transporters pNBC1, NHE1, NHE2, and Slc26a7, on gastric epithelial functions
    Ravens U.- Impaired vascular function in small resistance arteries of LOX-1 overexpressing mice on high-fat diet
    Rehberg M.- Spatial learning and long-term potentiation in aged chronically epileptic rats
    Rehn M.- Effects of H2O2 at rat myenteric neurones in culture
     - Involvement of cGMP-sensitive phosphodiesterases in the action of NO on rat myenteric neurons
    Reichold M.- KCNJ10 potassium channels in the mouse distal nephron
     - Monday, March 23, Audimax, Poster Area BPoster Session: Neuroprotection and hypoxiaModerators: D. Katschinski (Gttingen)U. Schrder (Magdeburg) TASK2 potassium channels are important determinants for central respiratory adaptation to hypoxia
     - Monday, March 23, Hall 1Main SessionPhysiology and pathophysiology of K2P -channelsSymposium of the Working Group Heart and Circulation PhysiologyChairpersons: J. Daut (Marburg)R. Warth (Regensburg) Invalidation of TASK1 K+ channels disrupts adrenal gland zonation and mineralocorticoid homeostasis
     - Expression and localization of the TASK K+ channels in adrenal glands
     - The role of TASK3 potassium channel in the regulation of aldosterone secretion
    Reifenberger G.- Tuesday, March 24, Audimax, Poster Area BPoster Session: Cell death and survivalModerators: G. Euler (Giessen),V. Shahin (Mnster) Expression of DNA-methyltransferases and DNA-methyl-binding proteins in intrinsic and UVB induced extrinsic skin ageing: a pilot study
    Reifenberger J.- Tuesday, March 24, Audimax, Poster Area BPoster Session: Cell death and survivalModerators: G. Euler (Giessen),V. Shahin (Mnster) Expression of DNA-methyltransferases and DNA-methyl-binding proteins in intrinsic and UVB induced extrinsic skin ageing: a pilot study
    Reinartz M.- Wednesday, March 25, Hall 4Oral SessionEndothelial cell biologyChairpersons: M. Cattaruzza (Heidelberg)T. Noll (Giessen) The cardiac ankyrin repeat protein (CARP) interacts with cytoplasmic -actin in migrating endothelial cells
     - Glycogen synthase kinase 3-beta (GSK3) forms multiple protein complexes
     - Comparative phosphoproteome analysis of NO induced heart failure
     - Identification of protein interactions of AKT2 via TAP and MS
    Reis A.- Inhibition of prolyl hydroxylase attenuates hypoxia-reoxygenation-induced injury in endothelial cells
    Reiser G.- Inhibition of Na+/H+ exchangers protects hippocampal slices from oxygen-glucose-deprivation induced injury
    Reiss B.- TGF-1-induced anchor sites in cell junctions detected by AFM
    Reiss M.- Sphingosine-1-phosphate receptors stimulate macrophage plasma membrane actin assembly via ADP release, ATP synthesis and P2X7 receptor activation
    Renigunta A.- The glycolytic enzymes GAPDH and enolase- serve as accessory proteins of the renal epithelial potassium channel hROMK-2 and regulate its function
     - Tamm-Horsfall glycoprotein interacts with renal potassium channel ROMK2 and regulates its function
    Renigunta V. K.- Tamm-Horsfall glycoprotein interacts with renal potassium channel ROMK2 and regulates its function
     - Mutation of the critical histidine residue in the T1 domain of Kv2.1 prevents the heteromeric assembly of Kv2.1/Kv6.x channels
    Renigunta V.K.- The glycolytic enzymes GAPDH and enolase- serve as accessory proteins of the renal epithelial potassium channel hROMK-2 and regulate its function
    Renker S.- COX-inhibition restores renal organic anion transport and positively influences renal outcome in a rat model of ischemic acute kidney injury
    Reshkin S. J.- Extracellular matrix digestion depends on the matrix composition and on NHE1 activity
    Rettig R.- Monday, March 23, Hall 3Oral SessionRenal transport IChairpersons: C. Wagner (Zrich, CH)R. Warth (Regensburg) Cyclosporine A-induced increases of renal and hepatic MDR1 expression do not depend on renal MRP2
     - Wednesday, March 25, Hall 4Oral SessionVascular inflammation: Clinical aspectsChairpersons: W. Franz (Mnchen)A. Grlach (Mnchen) The renin-angiotensin system as a primary cause in the pathophysiology of polyarteritis nodosa in rats
     - Superoxide formation in human intrarenal arteries is mainly due to NADPH oxidase activity and contributes to endothelium-dependent vasodilation
     - Amiloride potently lowers arterial pressure in Cyp1a1ren-2 transgenic rats without significant effects on small artery function
    Reusch H. P.- Sodium-bicarbonate co-transporter SLC4A7 modulates the mitochondrial pathway of apoptosis in coronary cells under ischemic stress
    Reuter J.- Enhanced hypoxia susceptibility in hippocampal slices from a mouse model of Rett Syndrome
    Revermann M.- sEH-deficiency attenuates neointima formation in the femoral artery cuff model of hyperlipidemic mice
    Rexhepaj R.- Hyperaldosteronism in Klotho-deficient mice
     - Responses to diuretic treatment of SGK1 knockout mice
     - SGK1-dependent regulation of intestinal peptide transport
    Reymann K.- Inhibition of Na+/H+ exchangers protects hippocampal slices from oxygen-glucose-deprivation induced injury
    Riaz M.A.- Activation of AMP-activated protein kinase protects endothelial barrier against reperfusion-induced failure
    Richter F.- Influence of otoplastics or hearing impairment on auditory evoked potentials, auditory evoked magnetic fields and source localization in professional musicians from classical orchestras
     - Transient anoxic depolarization is unable to condition the brainstem of adult rats for spreading depression (SD)
     - Sensitization of afferent nerve fibers by TNF in normal rat knee can be prevented by etanercept, COX-inhibitors, and by inhibitors of the p38 kinase pathway
    Richter J. F.- Tuesday, March 24, Hall 4Oral SessionKidney PhysiologyChairpersons: M. Gekle (Halle/Saale),F. Schweda (Regensburg) Tricellulin enhances the barrier for ions and for macromolecules depending on its localization within the tight junction
    Richter M.- Metabolic pathways regulate P-glycoprotein gene expression via reactive oxygen species
    Rieck J.- Monday, March 23, Audimax, Poster Area EPoster Session: Stem and progenitor cells and transcription factorsModerators: B. Fleischmann (Bonn)A. Sachinidis (Kln) Cytosolic exon(29)renin protects H9c2 cardiomyoblasts from necrosis induced by oxidative stress via beneficial effects on mitochondrial functions
    Riederer B.- Sunday, March 22, Hall 4Oral SessionIntestinal transportChairpersons: M. Bleich (Kiel)G. Breves (Hannover) Gastric KNCQ1 channels provide luminal K+ to the H+/K+ ATPase, whereas Kir 4.1 channels are involved in secretory membrane recycling
     - Genetic deletion of NHE3, Slc26a6 (PAT1), Slc26a3 (DRA) and CFTR helps unravel the different pathways for duodenal HCO3- and H+ secretion in vivo
     - Adrenaline-induced colonic K+ secretion is conducted via KCa1.1 (BK) channel: implications of a regulated ZERO splice variant
     - Sunday, March 22, Audimax, Poster Area BPoster SessionYoung Investigator Award (Poster):Channels and transportModerators: J. Daut (Marburg)J. Leipziger (Aarhus, DK) The PDZ proteins NHERF1 and NHERF2 have distinct roles in G-protein coupled receptor regulation of CFTR-mediated intestinal anion secretion in vivo
     - Downregulation of Na+/H+ exchanger isoform 3 (NHE3) function, but not expression, in colonic mucosa of patients with ulcerative colitis may be related to loss of PDZK1 adaptor protein expression
     - NBCn1 (Slc4a7) is a major HCO3- importer in murine duodenum and essential for basal and stimulated HCO3- secretion in vivo
     - Monday, March 23, Audimax, Poster Area EPoster Session: Gut and epithelial transporters IModerators: M. Ritter (Salzburg, AT)J. Roth (Giessen) Dual role of the Na+/H+ exchanger isoform 3 for PEPT1-mediated H+/dipeptide cotransport in native murine intestine
     - Preserved abundance but functional dysregulation of Na+/H+ exchanger isoform NHE3 in the small and large intestine in CD45RBhigh transfer colitis mice with diarrhea
     - Secretagogue stimulation enhances NBCe1-B (electrogenic intestinal/pancreatic Na+/HCO3- cotransporter) surface expression in murine colonic crypts
     - Effect of genetic ablation of the acid/base transporters pNBC1, NHE1, NHE2, and Slc26a7, on gastric epithelial functions
    Rieg T.- Impaired urinary concentration abilityin mice lacking adenylyl cyclase 6
    Riemann A.- Acidosis-induced activation of ERK1/2 and p38 kinases in rat prostate cancer cells (AT1)
     - Acidosis modulates invasiveness of rat prostate cancer cells (AT1) via MAPK
    Riepe K.- Use-dependent block of the transient outward K+ current in rat left ventricular myocytes by the anti-malarial drug primaquine
    Riethmuller C.- TGF-1-induced anchor sites in cell junctions detected by AFM
     - Extracellular ATP reduces paracellular endothelial permeability via mechanical relaxation
     - Atrial natriuretic peptide antagonizes the vasopressin mediated water permeability in inner medullary collecting duct cells via proteinkinase G
    Ringkamp M.- NGF induces long-term changes in axonal excitability of mechano-insensitive C-afferents in pig skin, in vivo
    Ringstad L.- Arteriosclerosis prophylaxis by Ginkgo biloba (EGb 761) in patients with metabolic syndrome
    Rinne S.- Identification of a C-terminal region causing intracellular retention of TASK-3 channels
     - Mutation of the critical histidine residue in the T1 domain of Kv2.1 prevents the heteromeric assembly of Kv2.1/Kv6.x channels
     - TASK-1 channels in cardiac muscle cells of murine and human heart
    Rinschen M.- Cyclosporin A induced apoptosis in primary cultured inner medullary collecting duct cells correlates with increased TNF expression
    Ristic D.- Reduced perception of vibration and myofascial pain during strong aerobic exercise in man
     - Tuesday, March 24, Audimax, Poster Area DPoster Session: Sensory PhysiologyModerators: S. Grnder (Aachen),F. Richter (Jena) Neuronal NOS mediates long-term facilitation of neck muscle nociception in anesthetized mice
    Ritter M.- Regulation of CD45 expression and correlation with apoptosis in myelomonocytic HL60 cells
     - Resveratrol inhibits stimulus-secretion-coupling and induces apoptosis in INS-1E rat insulinoma cells
     - The role of AMPK in the regulation of insulin secretion and proliferation in INS-1E rat insulinoma cells
     - The non-gastric H+/K+-ATPase ATP12A exerts an anti-apoptotic effect on butyrate-treated myelomonocytic HL60 cells
     - ICln-self interactions assessed by fluorescence resonance energy transfer (FRET)
    Robaye B.- The molecular compass for macrophage chemotaxis
    Rock J. R.- Monday, March 23, Hall 3Oral SessionEpitheliumChairpersons: K. Kunzelmann (Regensburg)H. Oberleithner (Mnster) Defective Ca2+ dependent chloride secretion by TMEM16A knockdown
    Roder M.- COX-inhibition restores renal organic anion transport and positively influences renal outcome in a rat model of ischemic acute kidney injury
    Rodrigues Camargo S. M.- ACE2 and collectrin are tissue-specific associated proteins of the amino acid transporter B0AT1 and B0AT1-Hartnup-causing mutations
    Roeper J.- Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP
    Rohde M.- Inhibitory interneurons are not required for metabotropic glutamate receptor-dependent LTD in the hippocampal CA1 region
     - Spatial learning and long-term potentiation in aged chronically epileptic rats
    Rohe C.- Establishing mRNA transfection procedures for functional CFTR correction
    Rohrbach S.- Long-term caloric restriction improves mitochondrial and left ventricular function in senescent rats
     - Mitochondrial biogenesis and PGC-1alpha deacetylation by physical activity: Intact leptin signaling is required
     - AMPK activation is indispensable for the protective effects of caloric restriction on left ventricular function in the postinfarct myocardium
    Rohsius R.- Amiloride potently lowers arterial pressure in Cyp1a1ren-2 transgenic rats without significant effects on small artery function
    Rolfes C.- TASK-1 channels in cardiac muscle cells of murine and human heart
    Romio M.- Role of CD73 (ecto-5-nucleotidase) on T-cell mediated immune response
     - Accelerated atherosclerosis inapolipoprotein E/ecto-5nucleotidase (CD73) double-deficient mice
    Rosenblatt K.- Hyperaldosteronism in Klotho-deficient mice
    Rosenkranz S.- Induction of diabetes like hyperfiltration in heterozygous eNOS mice overexpressing TGF-b1 does not depend on changes in the mRNA expression of fibrotic markers
     - Monday, March 23, Audimax, Poster Area DPoster Session: Regulation and myocardial metabolism and functionModerators: T. Noll (Giessen)H.-G. Zimmer (Leipzig) PPAR activation limits the nonenzymatic effect of renin on cell lengths in adult ventricular cardiomyocytes
     - From risk to heart failure in mice: Identification of UCP-2 and biglycan as potential risk factors in the left ventricle leading to severe heart failure
    Rosenwick C.- Extracellular matrix proteins are regulated by exhaustive exercise in trained athletes
    Roth A.- Wednesday, March 25, Hall 5Oral SessionVoltage-dependent channelsChairpersons: I. Dietzel-Meyer (Bochum)T. Noack (Rostock) Energy efficient propagation of action potentials in hippocampal mossy fibers
    Roth B.- Ileal smooth muscle contractile activity of neonatal mice is less sensitive to cAMP/PKA than to cGMP/PKG signaling
    Roth I.- Connexin 37: A modifier gene in atherosclerosis and thrombosis
    Roth J.- Spatiotemporal activation of the transcription factor NF-IL6 in the rat brain during systemic inflammation
     - LPS, MDP and FSL-1 induced cellular activation in rat area postrema microglial cells
     - Fever, sickness behavior and circulating cytokines in response to macrophage-activating lipopeptide-2 and lipopolysaccharide in toll-like receptor-2-deficient mice and CD36-deficient rats
     - The Organum Vasculosum Laminae Terminalis (OVLT) as a central nervous sensor for putative exogenous and endogenous pyrogens
     - The role of peripheral and central cyclooxygenase products in the manifestation of brain-controlled sickness responses during localized inflammation induced by macrophage-stimulating lipopeptide-2
     - Purinoceptor mediated signaling in neuronal and glial cells of the rat hypothalamic median preoptic nucleus
    Rothstein J. D.- Regulation of the EAAT3 by PIKfyve
    Rotte A.- SGK1-dependent regulation of intestinal peptide transport
    Rotte C.- Excitatory actions and corresponding innervation patterns of GABA, tyramine and octopamine in the cockroach salivary gland complex
    Rotterman K.- The glycolytic enzymes GAPDH and enolase- serve as accessory proteins of the renal epithelial potassium channel hROMK-2 and regulate its function
    Rottger Y.- Identification of a C-terminal region causing intracellular retention of TASK-3 channels
    Rottmann S.- Long-term depression of pain perception in man affects peripheral receptive fields
    Rubio-Aliaga I.- Monday, March 23, Audimax, Poster Area EPoster Session: Gut and epithelial transporters IModerators: M. Ritter (Salzburg, AT)J. Roth (Giessen) Dual role of the Na+/H+ exchanger isoform 3 for PEPT1-mediated H+/dipeptide cotransport in native murine intestine
    Ruckstuhl L.- Expression of the neutral amino acid transporter B0AT1 (Slc6a19) and its specific renal accessory protein collectrin in MDCK cell line
    Rudakova E.- Localisation of K+ channel subunits in lipid rafts and modulation of K+ currents by membrane cholesterol content in rat left ventricular myocytes
    Rueckschloss U.- Tuesday, March 24, Audimax, Poster Area FPoster Session: Contractile mechanisms andcardiac functionsModerators: K. Brixius (Kln)P. Sasse (Bonn) Superoxide and nitric oxide differentially modulate calcium transients and contraction in aged murine ventricular myocytes
    Ruetten H.- Monday, March 23, Audimax, Poster Area APoster Session: Cardiomyocyte membrane potential regulationModerators: T. Baukrowitz (Jena)R. Meyer (Bonn) Viable heart slices: Action potential recordings from atrial and ventricular tissues
    Ruhe C.- Nox1, Nox2 and Nox4 are key regulators of mouse embryonic stem cell-derived cardiovascular differentiation
     - Investigating the interplay of NO and ROS during cardiomyocyte differentiation from mouse embryonic stem cells
     - NAD(P)H oxidases are key regulators of cardiomyocyte differentiation from embryonic stem cells
    Rukwied R.- NGF induces long-term changes in axonal excitability of mechano-insensitive C-afferents in pig skin, in vivo
    Rumig C.- Fluid shear stress-induced expression of the human nos-3
    Rummel C.- Spatiotemporal activation of the transcription factor NF-IL6 in the rat brain during systemic inflammation
     - Leptin modulates neuroinflammation and neutrophil recruitment into the brain of mice during severe LPS-induced systemic inflammation
     - The role of peripheral and central cyclooxygenase products in the manifestation of brain-controlled sickness responses during localized inflammation induced by macrophage-stimulating lipopeptide-2
    Rump A.- A novel role of class 1 myosin: The tail domain of a class 1 myosin binds and stabilizes microtubules and modulates kinesin motility
    Ruth P.- Control of aldosterone secretion by ANP in adrenal slices from mice with disrupted BK channel subunits
     - Adrenaline-induced colonic K+ secretion is conducted via KCa1.1 (BK) channel: implications of a regulated ZERO splice variant

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