Back
Acta Physiologica 2012; Volume 206, Supplement 693
Joint FEPS and Spanish Physiological Society Scientific Congress 2012
9/8/2012-9/11/2012
Santiago de Compostela, Spain
SERUM ADIPONECTIN AND OXIDATIVE STRESS ASSOCIATION IN TYPE 2 DIABETES MELLITUS PATIENTS
Abstract number: P163
Bondor1 CI, Kacso2 IM, Lenghel2 AR, Muresan3 A
1Medical Informatics and Biostatistics Department, University of Medicine and Pharmacy "Iuliu Hatieganu",
2Nephrology Department, University of Medicine and Pharmacy "Iuliu Hatieganu",
3Physiology Department, University of Medicine and Pharmacy "Iuliu Hatieganu"
Objectives:
Endothelial dysfunction is an important determinant of oxidative stress; adiponectin has also been linked to these processes. In this study we assessed relationship of serum adiponectin with oxidative stress in type 2 diabetes patients.
Materials:
We included 64 consecutive ambulatory type 2 diabetic patients. Exclusion criteria were diabetic kidney disease stage 4–5 and recent history of inflammatory/infectious diseases. Urinary albumin-to-creatinine ratio (uACR) was determined as mean of three random morning urinary spot measurements.
Results:
Adiponectin was significantly correlated with uACR r=0.55, p<0.001; malondialdehyde (MDA) r=-0.28, p=0.03, HDL-cholesterol r=0.26, p=0.04; triglycerides r=-0.32, p=0.01 and abdominal circumferences r=-0.26, p=0.04. MDA was significantly correlated with glycated hemoglobin (HBA1c) r=0.40, p=0.0009; catalase r=-0.30, p=0.02 and systolic blood pressure (SBP) r=-0.28, p=0.03. In multiple linear regression MDA depended on adiponectin p=0.01, HBA1c p=0.003 and SBP p=0.05. We divided patients according to a cut-off (ROC curve) for adiponectin of 8.9mcg/ml. There was statistical significant difference between patients with adiponectin<=8.9mcg/ml (n=48) and patients with adiponectin>8.9mcg/ml for MDA (4.13±1.55nmol/ml vs. 2.92±0.79nmol/ml, p=0.005). Correlation between MDA and adiponectin was greater for patients with metabolic syndrome r=-0.32, p=0.03 (n=45), for patients with uACR>=30mg/g r=-0.56, p=0.004 (n=27), for patients with neuropathy r=-0.53, p=0.01 (n=21), for patients with glomerural filtration rate (eGFR/MDRD)<=60ml/min r=-0.58, p=0.02 (n=16). Correlation between MDA and adiponectin was not significant for patients with retinopathy r=-0.11, p=0.68 (n=17).
Conclusions:
Low level of oxidative stress correlated with high level of adiponectin in patients with diabetes type 2.
Acknowledgements:
The author CB was partly supported by European Social Fund within the Sectoral Operational Programme Human Resources Development 2007-2013-POSDRU /89/1.5/S/58965.
To cite this abstract, please use the following information:
Acta Physiologica 2012; Volume 206, Supplement 693 :P163