HMG-CoA reductase inhibitors (statins) are used in primary and secondary prevention of cardiovascular disease (CVD). In a rat model of maternally-induced CVD, chronic statin treatment restored endothelial function in adult rats. In a similar model, early targeted, acute interventions have long term benefits on cardiovascular function so it was hypothesised that early age acute statin treatment would improve cardiovascular function in later life in this model. Wistar rat dams were fed 18% protein (control, C) or 9% protein restricted (PR) diet throughout pregnancy and returned to standard chow on delivery. At weaning (3 weeks) pups were divided into a statin group (S) receiving atorvastatin (10mg/kg; Pfizer, UK) for 2 weeks or controls. This gave four groups: control (C), control + statin (CS), protein restricted (PR) and protein restricted + statin (PRS). At 16 weeks vascular reactivity of mesenteric arteries (MA) was measured by wire myography. Results are expressed as mean ± SEM and differences were assessed by one-way ANOVA. Significance was assumed at p0.05. Enhanced constriction to phenylephrine was observed in PRS groups in both males (mN/mm: C, 4.120.16, n=6; CS, 4.570.16, n=6; PR, 4.660.29, n=5; PRS, 5.270.21, n=5; p<0.01) and females (mN/mm: C, 3.220.26, n=5; CS, 4.170.23, n=6; PR, 3.820.40, n=5; PRS, 4.710.24, n=6; p<0.01). In female MA increased constriction to endothelin was also shown in the PRS group (mN/mm: C, 3.270.56, n=4; CS, 4.430.36, n=5; PR, 3.440.62, n=4; PRS, 6.200.89, n=5; p<0.01). These data show enhanced constriction in PR offspring, but not in controls, following statin withdrawal. The PR offspring appear to be more susceptible to statin withdrawal and subsequent rebound than controls.