High-resolution imaging approaches recently revealed that neurotransmitter receptors, embedded in the plasma membrane of neurons, dynamically explore synaptic and extrasynaptic membrane compartments. Although a lot of attention has been devoted to the understanding of the molecular and cellular mechanisms involved in the regulation of the receptor content in synapses, much less is known about the regulation of extrasynaptic receptor dynamics and its potential role. I will here described recent findings describing how the surface dynamics of extrasynaptic glutamate NMDA (NMDAR) and dopamine receptors are dynamically regulated. For instance, dopamine D1 receptors (D1R) are highly dynamic at the surface of hippocampal neurons. Their activation rapidly induces a lateral redistribution of both extrasynaptic D1R and NMDAR, impacting on NMDAR synaptic content and favouring synaptic long- term potentiation. At the macroscopic level, surface D1R and NMDAR form extrasynaptic clusters in the vicinity of the glutamate synapses, forming a reserve pool of perisynaptic NMDAR that can be mobilized on demand to synapse in a dopamine and developmental manner. Finally, I will further discuss evidences demonstrating the glutamate synapse remodelling is accompanied by rapid lateral redistribution of NMDAR subtypes between synaptic and extrasynaptic areas. Together, these data provide evidence that the extrasynaptic receptor trafficking is highly regulated, supporting the view that the extrasynaptic compartment integrate various intracellular and extracellular signalling.