Cytoplasmic protein talin connects integrin receptors to actin cytoskeleton. Talin is a large protein, which has several interaction partners. N-terminal head domain of talin resembles FERM-domains, and is responsible for the interactions with integrin. The C-terminal rod domain consists of alpha-bundles and contains several binding sites for vinculin. Talin is thought to act as integrin-activating protein, and it plays important role in the cell attachment. Talin also possibly acts as cellular force sensor. This could be mediated by the exposure of vinculin-binding sites in talin by mechanical stress.