Hormones and neurotransmitters are released from cells by being passed through an exocytotic pore that forms following the fusion of the vesicle and the plasma membrane. In a number of cell types exocytosis proceeds by two mechanisms: by the transient fusion also known as kiss-and-run, or by the full fusion. An elegant way to discern between these two mechanisms is to monitor fusion pore properties by the electrophysiological method of monitoring membrane capacitance (C_m), a parameter linearly related to the membrane surface area. In the past our focus was to study the release properties of pituitary cells at cellular level. However, to learn directly about the conductance and kinetics of the fusion pore, it is imperative to monitor the time-course of single fusion events in the cell-attached mode of recording. Our results show that by measuring discrete steps in C_m, we most likely monitored fusion-fission events of single vesicles. Moreover, the recorded reversible C_m steps most likely mirror transient (kiss-and-run) fusion events, while irreversible C_m steps most likely reflect full fusion events.