Osteoporosis is a bone disease characterized by reduced bone strength, which predisposes to increased risk of bone fractures. Strontium ranelate is a newly licensed drug, which has shown great promise in the treatment of osteoporosis and has been approved by the European Union on September 2004. In the present study, the effect of strontium ranelate treatment on skin biomechanical and biochemical properties were investigated. Twenty-one adult albino female Wistar rats weighing 200-250g were used in the study. Fourteen animals were ovariectomized by ventral incisions. The ovariectomized rats were randomly assigned into two groups. These groups were designed as ovariectomized group and treatment group. Ovariectomized group: Animals in this group (n=7) were administered placebo (saline) via oral gavage. Treatment group: Animals in this group (n=7) were treated with strontium ranelate (500 mg/kg/day p.o.) for 120 days, starting 90 days after ovariectomy. Other seven animals were named as control group: Animals in this group were administered placebo (saline) via oral gavage. The skin samples were excised and they were used for biomechanical and biochemical experiments. We measured stress, strain, toughness, malondialdehyde (MDA) concentration and antioxidant enzyme activities. In ovariectomized and treatment groups, stress and toughness values significantly reduced compared to the control group. In the ovariectomized group, strain value was significantly lower than control group. No statistical significance was found when treatment group was compared to ovariectomized and control groups. Skin MDA level increased almost two times in ovariectomized group, three times in treatment group compared to control group. Although catalase activity of skin decreased in treatment group compared to control, there were no significant differences for catalase activity between ovariectomized and control group. Skin SOD activity decreased in ovariectomized and treatment groups compared to control group. The results of this study show that the treatment of strontium ranelate has a negative effect on ovariectomized rats' skin.