11 female mice (mean weight 30.8±0.6 g) were anesthetized (chloralose 50 mg/100 g i.p.), paralyzed (cis-atracurium 0.5 mg/100 g i.p.) and trachetomized. A cannula was inserted into the second tracheal ring, and positive pressure ventilation (tidal volume 0.4 ml, breathing frequency 120/min) was started. The thorax was open, and the lungs exposed to athmospheric pressure. The tracheal cannula was connected to a constant flow pump set to deliver an inflation volume of 0.4 ml at a constant flow rate of 1 ml/sec. The time for the rise and the fall of flow was about 30 msec. Lateral tracheal pressure was monitored and recorded. The pressure tracings allowed the measurements of lung mechanics according to the end-inflation occlusion method. The mean value of static lung compliance (Cst,l) resulted 0.043±0.002 ml/cmH₂O and of total lung resistance (Rmax,l) 1.59±0.06 cmH₂O/ml sec^-1. The latter includes the newtonian lung resistance due to the movement of airflow and lung's tissue (Rmin,l = 0.38±0.03 cmH₂O/ml sec^-1), and the pressure dissipation due to stress-relaxation and time constants inhomogeneity within the lung (Rvisc,l = 1.21±0.05 cmH₂O/ml sec^-1). Equipment resistance (Req) was separately measured and subtracted from results, which hence represent intrinsic values. Confirming what observed in rats and humans, the component of visco-elastic pressure dissipation in mice lung is higher than the newtonian component. Mice lung mechanics measurements by the end-inflation occlusion method are scanty in the literature. Present results are generally comprised in the range of previously reported values for normal mice. Thus, present data validate our measurement technique. We conclude that the end-inflation occlusion method is suitable for mechanics measurements in the small mice lungs.