Objective: 

We aimed to investigate the effects of and caffeic acid phenethyl ester (CAPE) on adipokine (leptin, ghrelin, resistin) levels and lipid parameters in rats after chronic exercise.

Methods: 

This study was performed on 60 Sprague-Dawley male rats at 6 weeks. Groups were formed as follows: Group 1(sedantary+saline), group 2 (exercise+ saline), group 3 (sedantary+ ethanol), group 4 (exercise+ ethanol), group 5 (sedantary+ CAPE), group 6 (exercise+ CAPE). Leptin, ghrelin, and resistin levels were determined with ELISA technique and lipid concentrations (TG, TK, HDL-K) were measured with colorimetric methods in serum samples obtained from rats.

Results: 

Significantly decreased ghrelin levels in CAPE groups (p<0.05, p<0.01) were observed. Triglyceride levels were found to be significantly increased in sedantary+CAPE groups.

Conclusion: 

According to our findings we concluded two suggestions a) exercise alone can't be sufficient on weight loss. b) exercise is not the only factor which influence the studied parameters (leptin, ghrelin, resistin, TG, TK, HDL-K ve LDL-K). As a result, it can be suggested that exercise application with dietary restriction might more efficient in weight control.