Objective: 

To evaluate relationships between adipokines (adiponectin, resistin, leptin, interleukin-6, tumor necrosis factor-a) and cutaneous vasomotor responses in metabolic syndrome (MS) patients with insulin resistance (IR).

Methods: 

MS patients with IR were divided into two groups: 20 patients with type-2 diabetes mellitus (without insulin therapy and pronounced diabetic complications) (DM) and 20 patients without DM. 20 healthy subjects were selected as controls (C). The study groups were matched for age and sex. Adipokines were measured by xMAP technology. We recorded cutaneous laser Doppler flux (LDF) variables: postocclusive hyperemia (m1-LDF), vasoconstrictor response (v-LDF) to deep inspiration, and heat induced hyperemia (m2-LDF).

Results: 

Only the patient group with diabetes demonstrated a significant diminution in v-LDF compared to the group of healthy subjects (p<0.05). m1-LDF was decreased in both patient groups in comparison with the group of controls (p<0.05), but only in diabetics the decrease of m2-LDF was significant (p<0.05). Adipokines levels were changed (p<0.05) in diabetic patient group.

Conclusion: 

MS patients with IR have significant cutaneous vasomotor dysfunction but diabetics (with IR and MS) have also changed adipokines levels.