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Acta Physiologica 2009; Volume 196, Supplement 671
Scandinavian Physiological Society’s Annual Meeting
8/14/2009-8/16/2009
Uppsala, Sweden
TRANSGENERATIONAL EFFECTS OF ACUTE HYPOBARIC HYPOXIA OF EARLY ORGANOGENESIS ON WHITE RATS POSTERITY BEHAVIOR AND COGNITION FUNCTION
Abstract number: O6
DUNAEVA1 TY, GRAF1 AV, TROFIMOVA1 LK, CHIRAZOVA1 EE, MASLOVA1 MV, MAKLAKOVA1 AS
1119992,Biology Faculty, Lomonosov Moscow State University, Leninskie Gory 1/12, Moscow, Russia. [email protected]
Objective of the study was to investigate delayed effects of acute hypobaric hypoxia on second generation (F2) posterity behavioral patterns and cognition function. Earlier we have demonstrated that in first generation (F1) females showed decreased linear locomotion and rearing in "Hole board" and increased risk coefficient (sum of open arm visits, rearing on open arms and overhanging) in elevated plus-maze. That's why we fixed our attention on F2, born by F1 females after mating with intact males. Methods. The rats on the 9th day of pregnancy were subjected to acute hypoxia in an altitude chamber. Two posterity generations have been grown up. At the age of 57 days, considered to be pubertal period, the motor and exploratory activity of the second F2 animals was tested in "Hole Board", and the anxiety level was assessed using an elevated plus-maze. At the age of 60 days education with positive reinforcement in "Complex maze" test has been started. Results. F2 males showed no alterations of behavioral patterns, while F2 females showed lower linear locomotion (36.9±3.6 vs 52.1±2.9), rearing (7.0±1.0 vs 9.2±0.9) and center visiting (2.1±0.5 vs 4.0±0.6) in "Hole board" and decreased risk coefficient (0.4±0.2 vs 1.6±0.4) in elevated plus-maze. Besides, we registered elimination of gender differences of these patterns. F2 females showed no changes of learning ability, whereas males showed decreased success frequency (0.2±0.1 vs 0.6±0.1) and increased performance latency (162.7±10.4 vs 109.1±17.2) on the 3rd day of education. Conclusion. Acute hypoxia of early organogenesis provoked variations of behavioral and cognition patterns of white rats at least in two generations. Females demonstrated altered behavior, and males decreased learning ability.
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Acta Physiologica 2009; Volume 196, Supplement 671 :O6