Objective: To evaluate the hemodynamic effects of two models of coronary artery occlusion in pigs. Methods: LV function was assessed by the slope (E_es) of ESPVR and stroke work (SW), and systemic arterial properties, including peripheral resistance (R₂), compliance (C), and arterial elastance (E_a) with a windkessel model. Ventriculo-arterial (VA) coupling was defined as E_es/E_a, and mechanical efficiency as SW/pressure-volume area (PVA). After baseline, the pigs were randomised in 2 groups: in group LIG (n = 6), LAD coronary artery was ligated, while in group FeCl₃ (n = 6), it was wrapped for 45 minutes with a strip satured with FeCl₃. Results: LAD coronary artery flow dropped immediately to zero in group LIG, but progressively decreased in group FeCl₃ (occlusion time 23.2  1.2 min). In group LIG, mean aortic pressure (P_mean) and flow (Q_mean) decreased abruptly, between baseline and T60, from 101  3 to 78  6 mmHg and from 56.4  5.4 to 34.9  3.8 ml/sec, respectively, while HR was unchanged; R₂ and E_a increased from 1.77  0.33 to 2.33  0.22 mmHg.sec/ml, and from 3.12  0.22 to 4.24  0.28 mmHg/sec, respectively, while E_es dropped from 2.7  0.3 to 1.7  0.4 mmHg/sec. VA coupling falled from 0.90  0.19 to 0.41  0.12, while SW/PVA dropped from 0.85  0.12 to 0.59  0.06. Most significant hemodynamic changes were observed in the first 30 min after the LAD ligation. In group FeCl₃, P_mean remained constant, while Q_mean progressively decreased from 57.8  6.6 to 47.3  5.5 ml/sec, and HR increased from 107  10 to 142  13 beats/min, between baseline and T180; R₂ and E_a increased from 1.72  0.22 to 1.95  0.28 mmHg.sec/ml, and from 2.99  0.33 to 3.55  0.22 mmHg/sec, respectively, while E_es decreased from 2.7  0.4 to 2.2  0.3 mmHg/sec. VA coupling falled from 0.90  0.16 to 0.63  0.18, while SW/PVA dropped from 0.85  0.07 to 0.72  0.07. Most hemodynamic changes observed in the FeCl₃ were progressive. Conclusion: Progressive coronary artery occlusion, as obtained by topical FeCl₃ application, is responsible for a less impaired hemodynamic condition. This model, closer to the clinical condition of coronary artery thrombus formation, could be more suitable to assess pharmaceutical or mechanical cardiac support during acute myocardial ischemia.