Several steps can be considered in regulation of lipid oxidation in skeletal muscle during exercise. The lecture will focus on regulatory molecular steps involved in utilisation of lipid fuels in skeletal muscle during exercise. Transmembrane and cytosolic transport of lipids is considered. Furthermore, the putative role of AMP- activated protein kinase (AMPK) in lipid metabolism during exercise as well as in regulation of lipid entry into the mitochondria will be discussed. With regard to the latter, focus will also be on acetylCoA carboxylase (ACC) and carnitine. The contribution of triacylglycerol located in skeletal muscle (IMTG) for energy provision may not be large covering about 10% of total energy provision during fasting exercise in male subjects whereas in females, IMTG may cover a larger proportion of energy delivery. Molecular mechanisms involved in breakdown of IMTG during exercise are also considered focussing on hormone sensitive lipase (HSL) and the regulation hereof in human skeletal muscle.

REFERENCE

Kiens, B. 2006. Skeletal Muscle Lipid Metabolism in Exercise and Insulin Resistance. Physiol Rev 86, 205-243.