Aim: 

to investigate the action of the antagonists of the H₃-histamine receptors on fast motility of stomach and duodenum in dogs.

Methods: 

the investigations were carried out in chronic experiments on dogs with fistulas of fundal part of stomach and duodenum. By ballonographic method we recorded the periodical motility of stomach and duodenum and studied the influence on it the antagonists of H₃-histamine receptors: thioperamide (0.07 mg/kg, intravenously), betahistine (1.2 mg/kg, in duodenum).

Results: 

in the control experiments the phase of rest in stomach lasted 46.8 ± 12.5 min and in duodenum 29.14 ± 7.2 min. The phase of work in stomach and in duodenum lasted 44.3 ± 14.6 and 61.3 ± 10.1 min, consequently. Thioperamide evoked the lengthening the phase of work of periodical motility in the stomach on 93.5% (p < 0.01) and in duodenum on 61.3% (p < 0.01). The phase of rest in the stomach decreased on 10.8% (p > 0.05) and in duodenum on 28.9% (p < 0.01). Another antagonist betahistine had the analogical effect on the duration of the phases of periodical motility. Betahistine increased the duration of the phase of work in stomach and duodenum on 100.5 and 72.3% (p < 0.01), accordingly. Whereas the duration of the phase of rest were diminished in stomach on 39.7% and in the duodenum 39.3% (p < 0.01).

Conclusion: 

1. Endogenous histamine acting on H₃-histamine receptors determine the duration of the phases of rest and work of periodical motility.

2. Antagonists of H₃-histamine receptors may be useful in patients with disturbances of periodical motility of gastrointestinal tract.