Aims: 

In a common blood circulation river-bed histamine shows vasodilatation properties. The purpose of the study was to discover effects of histamine on hepatic portal vessels and hepatic blood filling.

Methods: 

Experiments registered the system arterial and portal pressurechanges. For this purpose were cannulation of general carotid and portal vein done. One more catheter was used for intraportal conduction of the explored preparations. Hepatic blood filling was registered by the methodof impedance reography. Research was made in sharp experiments on white laboratory rats (weight 200 – 300 g). Rats were anaesthetized by intracavitary conduction of urethan solution (1 g/kg).

Results: 

Intraportal conduction ofhistamine did not draw the reactions on system arterial pressure. At the same time were observed vasomotor effects of histamine in the vascularriver – bed of liver. Actually, the blood pressure in portal vein increased on 53.4 ± 15.7% in relation to an initial level. The latent period of pressorial reaction in the portal vessel was 9.6 ± 2.0 s, and the maximum of reaction amounted in 17.5 ± 3.7 s after the beginning of conduction of preparation. At the same time with the changes of pressure in portal vein, hepatic blood filling decreased on 18.7 ± 6.6% (p < 0.05).

Conclusion: 

In the hepatic portal system histamine shows vasoconstrictor effects, which are accompanied by the increase of tone of portal vein and decrease of hepatic blood filling.