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Acta Physiologica 2007; Volume 191, Supplement 658
Joint Meeting of The Slovak Physiological Society, The Physiological Society and The Federation of European Physiological Societies
9/11/2007-9/14/2007
Bratislava, Slovakia
MICRO POSITRON EMISSION TOMOGRAPHY AS AN IMAGING TOOL FOR MONITORING OF TUMOURS AND DEFINED BRAIN STRUCTURES ACTIVITY
Abstract number: PTH14-112
Jakubikova1 L., Petrak1 J., Ondkova1 S., Macejova1 D., Mravec1 B., Brtko1 J., Kvetnansky1 R., Kovac1 P., Strbak1 V.
1Institute of Experimental Endocrinology, Slovak Academy of Sciences (IEE SAS); Joined research MicroPET Laboratory of IEE SAS and BIONT a.s., Bratislava, Slovak Republic; [email protected]
Aims:
The objective of this study was to analyse in vivo monitoring ofdisease progression or a state of metabolic/therapeutic processes in the small laboratory animals by micro positron emission tomography (mPET). Uptake of [18F]-Fluoro-2-deoxyglucose (FDG) reflecting metabolic activity of the tissue can be used for monitoring of response to chemotherapyin some forms of cancers. Moreover FDG is also a marker of neuronal activity.
Methods:
Longitudinal development of response to a specific new chemotherapy of tumours was measured by uptake of FDG in tumours as a "pre-therapeutic" staging and three months after therapeutic interventionas "therapeutic monitoring". We also investigated whether FDG uptake will reveal activation of discrete brain structures in rats exposed to stressful stimuli.
Results:
Images of individual tumours allowed quantification oftumour's volume, metabolic activity and their possible dependence and changes of their relation in time. mPET imaging revealed to be useful toanalyze activity of discrete brain structures like thalamus, hypothalamus, frontal cortex, striatum and quantify their metabolism.
Conclusion:
mPET for small laboratory animals is suitable non-invasive imaging method for repeated monitoring of tumour diseases and effect of possible therapy. The images of FDG accumulation also revealed feasible application of mPET in study of neuroendocrine regulation. This work was supported by project ofthe ESF No 13120200067 and APVV Grant No 0148-06.
To cite this abstract, please use the following information:
Acta Physiologica 2007; Volume 191, Supplement 658 :PTH14-112