Aims: 

The cerebellum and inferior olive provide transformation and integration of diverse influences, in particular vibration. This is necessary for the adequate control of motor activity. Therefore, a comparative study of baseline activity of cerebellar and olivary neurons in the dynamics of vibration influence was conducted.

Methods: 

In acute experiments on Nembutal-anesthetized albino rats, extracellular recording of baseline activity of neurons in the fastigial nucleus of cerebellum and inferior olive were performed in norm and after exposure to whole – body vibration for 5, 10 and 15 days. The distributions of neurons were analyzed in terms of the regularity and dynamic of spike flows along with the mean spike frequency and the coefficient of variation of interspike intervals.

Results: 

The significant increase of average frequency of neurons' impulsation in both fastigial nucleus and inferior olive were observed at 5^th day of influence. Starting from 10^th day of exposure there was a gradual transformation of the rhythm of fastigial neuron activity, which by 15^th day turned into a sharp decrease, along with significant increase in the coefficient of variation. We have revealed also drastic decrease in quantity of neurons with group activity and mean frequency of impulsation of olivary neurons on day 10 of influence that stayed in the same level on 15^th day, along with an increase in the coefficient of variation.

Conclusion: 

These results testify to weakness of vibration stimulative influence on the neuronal activity of these structures and initiation of adaptive processes occurring at 10^th day of action of factor.