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Acta Physiologica 2007; Volume 191, Supplement 658
Joint Meeting of The Slovak Physiological Society, The Physiological Society and The Federation of European Physiological Societies
9/11/2007-9/14/2007
Bratislava, Slovakia
STORE-OPERATED CALCIUM ENTRY IN SENSORY DRG NEURONS
Abstract number: PW01-7
Korol1 S., Korol1 T.
1Department of General Physiology of Nervous System, Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Kiev, Ukraine [email protected]
Aims:
It is known that store-operated calcium influx is the main route of Ca2+entry in non-excitable cells. Recently this type of Ca2+entry was revealed in neurones. But there are few works dedicated to store-operated Ca2+entry (SOCE) in neuronal cells. The aim of this study was to discover SOCE in sensory DRG neurons mediated by caffeine-sensitive Ca2+stores.
Methods:
Current-voltage relationships have been recorded in control conditions and after applying caffeine by means of patch clamp technique from rat acute isolated sensory DRG neurons. Results:
Difference between these two relationships turned out to be similar to current-voltage relationship of store-operated Ca2+channels. It has region of inward rectifying and very positive reversal potential (>+70 mV). After applying the blocker of store-operated Ca2+channels 2-APB, this difference disappeared.
Conclusion:
These results demonstrated that sensory DRG neurons needs in one else mechanism of Ca2+entry besides the voltage-operated one. We conclude that SOCE is one of the constituents of calcium signaling in sensory DRG neurons.
To cite this abstract, please use the following information:
Acta Physiologica 2007; Volume 191, Supplement 658 :PW01-7
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