At the medical faculty of the University of Kiel, e-learning is integrated into the physiology curriculum covering lectures, lab courses, seminars, propaedeutics and a physiology forum. In "blended learning" scenarios this method supplements more traditional methods of teaching and learning with the objective to support students' learning. For example, face-to-face teaching in lectures focuses on the presentation of concepts and interrelations. Students use the faculty's e-learning platform NICKELS (http://www.e-learning-service.de/) in order to repeat the content of the lectures, to enhance their knowledge by working on special e-learning modules for self determined learning, to get feedback about their learning progress and to pose questions to the lecturer. In physiology lab courses, e-learning is utilized to supplement the traditional manuals, e.g., with videos demonstrating the performance of the experiments. A skills lab ("introduction to clinical medicine") in the 4^th term aims at integrating clinical and preclinical knowledge. The learning of medical examination techniques is coupled with the repetition of the anatomical and physiological basics as well as with typical patient cases in which these techniques are applied. This novel approach was developed in the innovative joint project "CliSO – Clinical Skills Online" with the medical faculty of the LMU Munich: Two platforms that complement each other were connected with regard to technique and content: NICKELS which is specially suited for systematic learning and communication and CASUS which focuses on case based learning. Before attending a face to face lab course where the skills are learned and practiced in small groups, students work through a patient case, repeat basic knowledge and get first standardized demonstrations of the skills in videos via the e-learning platforms. Evaluations reveal that this approach is very much appreciated by the students.