Our goal is the rehabilitation of goal-directed hand and finger movements following localized brain lesions of vascular or traumatic origin. Our concept is based on an activation of a reorganization process in the CNS by induction of a propriocep-tive inflow, physiologically corresponding to the lost inflow during active movements. Hence we use the repetitive peripheral magnetic stimulation (RPMS) which depolarizes thick myelinated nerve fibers of the terminal sensorimotor branches, generating an adequate (activation of mechanoreceptors during the induced contraction and relaxation) and an inadequate (via the direct activation of the sensorimotor afferents) inflow. Due to RPMS of the upper extremity muscles, different effects can be observed: Spasticity independent of the level of origin can be suppressed. The muscle stiffness around the elbow joint during alternating movements under relaxed state is modified due to the RPMS target muscle. In disturbed goal-directed motor perfor-mances the regularity of the performed trajectory could be im-proved. The position sense (proprioceptive only) during pointing tasks shows remarkable improvements in healthy subjects. In a PET-study on 8 patients it was shown that areas of the fronto parietal circuits are activated. Therefore we suppose that RPMS primarily facilitates the parieto-frontal neuronal circuits involved in goal-directed movements.