Stress plays the significant role in the pathogenesis of mental disorders including anxiety and depression, which have dramatic impact on human and animal biology. Exposure to stress has detrimental effects on the impairment of antioxidant defences, leading to oxidative damage. WE suggest that an antioxidant administration will decrease impair consequences of stress and preserve developing the stress-related damages. We applied adiachrom (AD) to previously stressed rats. AD belongs to bioflavonoids family with significant antioxidant properties. The animal's behavioural activity were measured in Open Field Test. According to obtained data we suppose that AD administration can decrease the stress impairment pattern and attenuate the developing of stress-related behavioural activity's inhibition. For example, the locomotor activity of stressed rats decreased at the beginning of post-stress period and increased two weeks after by AD administration. The further study of stress-induced reactions and their modifications by antioxidant agents treating will help to clear mechanisms of stress-related behavioural disorders and to provide some novel therapeutic strategies to the treatment of impair anxiety and depression.