Cisplatin is used to treat various tumours but it shows serious side effects as well. It is oto-, nephro- and neurotoxic and the effects were attributed to disturbances in calcium homeostasis. The effect of cisplatin on voltage activated calcium, potassium and sodium channels of dorsal root ganglion neurones, taken from `wistar´rats was examined in this study by means of the whole cell patch clamp method. Cisplatin reduced the voltage activated currents of the channels tested in a dose dependent manner though with different efficiency. Voltage activated calcium channel currents (VACCCs) have a threshold concentration around 1 mM, 10 mM cisplatin reduces the current by 45%± 7.8% and currents are almost fully inhibited at 100 mM (reduction of 76.7%± 3.9%). Voltage activated potassium channel currents (VAPCCs) are less affected. Cisplatin in a concentration of 10 mM (100 mM) reduces the current by 20.9%±4.7% (51.9%± 8.4%). Voltage activated sodium channel currents are reduced by 9.8%± 5.3% at a concentration of 10 mM. These results are true for small cells (diameter up to 20 mm). Voltage gated channels of large cells (diameter above 25 mm) are less sensitive. VACCCs (100 mM) are reduced by 14.05%± 5.27% and VAPCCs (100 mM) by 12.7%± 3.4%. Our findings might be linked to the sensible neuropathologic effects induced by cisplatin.