The purpose of this study is to evaluate some osteogenic markers involved in bone remodeling, such as osteoprotegerin-ligand (RANKL) and PMN-elastase concentrations in the sinovial fluid, as well as in the serum of patients with rheumatoid arthritis (RA). These measurements were performed in the initial stage of the disease, without using any anti-inflammatory non-steroidal therapy for at least 1 month before the beginning of the study. The concentration of RANKL in the sinovial fluid was 3.7±1.35 pmol/l, while the serum level was 2.23±1.18 pmol/l. The RANKL serum was significantly higher (p<0.01) compared to its concentration measured in the serum of the control group (1.3±1.16 pmol/l). The increase of PMN-elastase concentration evolved in the same manner in both serum and sinovial fluid, ranging 44.44±14.04 ng/ml and 3.15±1.94 ng/ml respectively, compared to its serum level in the controls (3.52±2.65ng/ml). The increased values of RANKL and PMN-elastase in the sinovial fluid of RA patients suggests the existance of an intense local bone remodeling process.