ATP^4-metabolism is associated with acid base-base production as recently reminded by Robergs et al. (2004). ATP^4-- related acid - base production can be considered as H⁺ / H₂O exchange or, more simple, as OH^-production and uptake. In the presented paper, ATP^4-related net production, uptake, and circulation of OH^-in cytosol are studied theoretically, applying stoichiometry and principles, previously developed for facilitated CO₂ diffusion. It is derived that 1 OH^-per 1 ATP^4-is produced during glycolytic as well as during oxidative ATP^4-- synthesis and that 1 OH^-/1 ATP^4-is taken up during ATP^4-- break down. For red cells it is derived that OH^-is carried from the ATP synthase system to the ATPase system predominantly by CO₂ in form of HCO₃^-(= CO₂OH^-) and, to minor extent, by water diffusing in exchange to protonated protein and phosphate. In cells containing the creatine kinase system (CK), OH^-is carried by HOH diffusing with phosphocreatine in exchange to creatine. OH^-is transported backwardly to the ATP^4-synthase molecules by flux of uncharged HO- in HPO₄^2-(= HO-PO₃^-) and separate flux of the negative charge within ADP^3-and creatine respectively. -It is concluded that, intracellular energy transfer is generally associated with OH^-circulation where CO₂, creatine / phosphocreatine and phosphate are the carriers.