Hippocampus is heavily implicated in long-term potentiation and long-term depression which may represent as cellular mechanisms for learning and memory. There is increasing evidence that the hippocampus relies on input from the vestibular system in the inner ear in order for spatial memory to occur. There is no evidence for a direct projection from the vestibular system to the hippocampus. However, several potential polysynaptic pathways have been described. Behavioural studies have shown that disruption of peripheral vestibular function results in an impairment of spatial learning and memory in the hippocampus. Since damage to the vestibular system causes disruption of learning and memory in humans and animals, the aim of this study was to determine whether or not LTP and LTD would be impaired in the CA1 region of the hippocampus following unilateral vestibular deafferentation. Our results demonstrated for the first time that LTP and LTD were intact at 2, 4 and 12 weeks after unilateral vestibular damage. This is the first study to demonstrate that despite a severe deficit in spatial learning and memory after unilateral vestibular lesion, long-term plasticity remained largely unaltered.