Krushinski-Molodkina rats exhibit different kind of epileptic activity as a response to auditory stimulus. The rats that develop generalizing seizure activity were used for hystochemical and immunohystochemical investigation of GABA-ergic cells and principal neurons in different areas of hippocampus, piriform cortex, audiotory cortex and colliclulus inferior. Especially, 1 month after exposure to stimulus, the quantitative analysis of GABA-ergic cells and principal neurons in different areas of hippocampus, piriform cortex, auditory cortex and colliculus inferior was made. The cell loss is more prominent in hippocampus and piriform cortex, lesser - in colliculus inferior and auditory cortex has almost normal structure. Thus, the Kroushinski-Molodkina rats - animals with inherited peculiarity to develop auditory seizure activity -as a response to audiotory stimulus are characterized by the more prominent cell loss in limbic structures then in auditory zones directly responding to stimulus.