Functioning of erythrocytes depends on state of their membranes. Erythrocyte membranes are affected substances got into blood. This study was undertaken to investigate influence of the basic component of rocket fuel 1,1-dimethylhydrazine (1,1-DMH) on the condition of human erythrocyte membranes. Hemolysis in isotonic and hypotonic solutions, peroxyde resistance, activity of catalase of erythrocytes was investigated in vitro. The results of our experiments have shown, that 1,1-DMH (3–650 mM) causes dose-dependent increase of hemolysis degree in hypotonic and isotonic solutions of NaCl. Activity of catalase was raised and peroxyde hemolysis was reduced in concentrations of 1,1-DMH up to 3 mM. At higher concentration of 1,1-DMH (up to 26ìÌ) these parameters remained at same levels. The further increase of substance concentration reduced catalase activity and raised peroxyde hemolysis. Probably, increase of catalase activity at low concentration of 1,1-DMH led to decrease of H2O2 concentration in the environment, and it was reason of reduce of peroxyde hemolysis. The increase of hemolysis in solutions of NaCl and H2O2 at high concentration of 1,1-DMH could be caused not only as a result of decrease of catalase activity by intensification of peroxidation of membrane lipids.

This study was supported by the grant (451.2 ISTC).