A number of past studies have focused on olfactory responses at the level of both the olfactory epithelium and the olfactory bulb (OB) of aquatic species. However, the recording and analysis of responses to a high number of odorants of many individual olfactory glomeruli is to date missing. Here we report on amino acid-evoked responses of individual glomeruli in the OB of Xenopus laevis tadpoles. We first show that only glomeruli in the lateral half of the OB respond to mucosal application of amino acids and that in cases where an individual glomerulus responds to more than one amino acid, the intraglomerular appearance of the [Ca2+]_i responses of different amino acids is virtually identical. We further recorded the response profile to 15 amino acids of a high number of individual glomeruli, show that there is a strong tendency of glomeruli to respond to few rather than to many amino acids and that the response frequency of basic and aromatic amino acids is explicitly higher than that for the other two subgroups of amino acids that were applied. Surprisingly, the glomerular response profiles were partly contradictory to the response profiles of olfactory receptor neurons of the same species obtained in a previous study. We thoroughly compare the two datasets and give some possible explanations of these inconsistent results. [Supported by DFG:SFB 406 (B5) and by DFG Research Center for Molecular Physiology of the Brain (CMPB, Project B4)]