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Acta Physiologica 2006; Volume 186, Supplement 650
Joint Meeting of The German Society of Physiology and The Federation of European Physiological Societies 2006
3/26/2006-3/29/2006
Ludwig-Maximilians-University, Munich
THE CARDIAC CALCIUM CHANNEL REGULATES MORE THAN JUST CARDIAC CONTRACTILITY.
Abstract number: SW6-5
Hofmann1 F, Kleppisch1 T, Lee1 TS, Moosmang1 S, Wegener1 J, Welling1 A
1Institut fr Pharmakologie und Toxikologie, TU Mnchen
Classical inactivation of the L-type Cav1.2 (a1C) calcium channel gene is embryonal lethal before day 14.5 pc (1). We have generated a mouse line in which exon 14 and 15 of Cav1.2 is flanked by two loxP sites. These mice were crossed with various lines expressing tissue-specific Cre The off-springs of these mice had severe defects in insulin secretion (2), blood pressure regulation (3), intestinal muscle contraction (4), hippocampal memory acquisition (5). These mice lines showed that mibefradil lowers blood pressure by inhibition of the Cav1.2 channel (6). Together, these results show that the L-type Cav1.2 channel mediates a number of cellular functions not identified previously by pharmacological and electrophysiological techniques.
1) Seisenberger et al. (2000) JBC 275, 39193--99.
2) Schulla et al. (2003) EMBO J 22, 3844--54
3) Moosmang et. al. (2003) EMBO J 22, 6027--34
4) Wegener et al. (2004) FASEB J 18, 1159--61
5) Moosmang et al. (2005) J Neurosci 25, 9883--92
6) Moosmang et. al. Circ Res. 2005 Nov 23; [Epub ahead of print]
To cite this abstract, please use the following information:
Acta Physiologica 2006; Volume 186, Supplement 650 :SW6-5