Energy homeostasis and temperature regulation are important integrative physiological processes with a strong pathophysi- ological and clinical relevance. Therefore, it is important to develop practical teaching elements for these objectives. Be-sides determination of their body-mass-index and discussion of its relevance the students perform two major experiments. During experiment A (energy turnover & feedback temperature control) O2-expenditure, energy turnover, heat release (by radiation, convection and evaporation) as well as heat storage is determined under three conditions (supine, sitting, during exercise of 100-150 W). For each condition energy and heat release are balanced and the relative contributions determined. The students learn the relative contribution of heat production and the different forms of heat release for energy expenditure during rest and exercise. In experiment B (anticipatory tem-perature control) blood flow in the 3rd finger of the right hand and heart rate are determined by plethysmography before and during immersion of the left hand in ice water. Blood flow in the right hand changes immediately without alterations of heart rate and before changes of the core temperature occur. The concept of feed-forward regulation and basic principles of hemodynamic regulation can be explained.