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Acta Physiologica Congress

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Acta Physiologica 2007; Volume 189, Supplement 653
The 86th Annual Meeting of The German Physiological Society
3/25/2007-3/28/2007
Hannover, Germany


MEMORY FOR EXPERIMENTALLY INDUCED PAIN - A CAPSAICIN STUDY
Abstract number: P21-L2-03

Jantsch1 HHF, Gawlitza1 M, Magerl1 W, Geber1 C, Birklein1 F, Treede1 RD, Baumgartner1 U, Kramer1 HH

1Institut fr Physiologie, Neurologie, Universitt Mainz

Pain memory after intracutaneous injection of capsaicin was studied in nine healthy male volunteers. Three different doses of capsaicin (0,05mg, 1mg and 20 mg) were applied in a balanced scheme concerning capsaicin dose, injection site and time of rating. The subjects rated their pain on a visual analogue scale (VAS) running on the program DapSys 3 at four different times: acute, one hour, one day and one week later. The dose of capsaicin injected was readily discriminated in all subjects (all differences p<0.005). Analysing the impact of assessment times on pain rating revealed that subjects were well capable to remember duration and intensity of capsaicin pain (median correlation coefficient: r(0,05mg)=0,824, r(1mg)=0,828; r(20mg)=0,771). However, the magnitude of pain rating varied significantly across assessment times (ANOVA: F(3,288)=9,03; p<<0,001), specifically recall at one hour after capsaicin returned significantly lower pain ratings compared to all other times (approximately 25% lower, p<<0,001). We conclude that by and large explicit pain memory retains reliably the temporal structure of the pain experience. However, the magnitude of pain is likely subject to an emotional-affective evaluation bias. Acknowledgement: Supported by Maifor, DFG and BMBF

To cite this abstract, please use the following information:
Acta Physiologica 2007; Volume 189, Supplement 653 :P21-L2-03

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