Olfactory information processing is influenced by a variety of neuromodulators at different stages of the olfactory system. Here, we demonstrate for the first time that odor processing is influenced by the cannabinergic system and discuss its possible function. We report on cannabinergic actions in the olfactory system of Xenopus laevis tadpoles. By means of calcium imaging and patch clamp we show that cannabinergic substances alter odor induced neuronal activitiy patterns and spike associated currents. Furthermore we describe the cellular distribution of CB1 receptors using CB1 immunoreactivity.

[Supported by the "Research program, Faculty of Medicine, Georg-August-University, Goettingen]