Angiotensin II (Ang) is known to induce heart failure. Beside the pharmacological intervention with ACE-inhibitors or AT1 blockers, stem cell therapy may play an attractive alternative. This study describes the contractile function of insufficient cardiomyocytes after treatment with statins or after PTH addition (PTH increases the release of G-CSF, a factor which increases the mobilisation of stem cells) and the effects caused by the addition of supernatant of ex vivo generated cardiac progenitor cells. Freshly isolated cardiomyocytes of adult rats were stimulated with Ang (100 nM) for 24 hours. Parameters of contractile function were examined at 0.5, 1.0, and 2.0 Hz via a line camera. The supernatant of ANF expressing ex vivo generated cardiac progenitor cells was used to examine the influence of generated and secreted factors. Cells chronically stimulated with Ang (100 nM) showed a loss in contractile function of 25 %. Treatment with cerivastatin (100 nM) totally diminished this Ang-induced effect. The addition of PTH increased concentration dependently the angiotensin-mediated effects. Less efficient effects could be detected with the supernatant of progenitor cells. Treatment of heart failure with statins seems to be more efficient than treatment with factors produced by generated progenitor cells to reduce signs of heart failure in this cell culture model. PTH seems to be a new promising therapeutic target in heart failure to improve heart function.