The aim of the Epitheliome Project (http://www.epitheliome.com) is to develop a computational model of cell behaviour within the context of tissue architecture, differentiation, wound repair and malignancy. The biological models used as exemplars are in vitro models of skin (Professor Sheila Mac Neil, Sheffield) and urothelium (Professor Jenny Southgate, York). An individual- based modelling paradigm is used in which there is a 1:1 mapping between biological entities (cells, protein molecules, receptors etc) and the software agents (specifically, communicating stream X-machines) which are used to represent them in silico. The modelling framework is publicly available (http://www.flame.ac.uk). The presentation will describe the modelling process, starting with a natural language description of the problem, and leading to an in silico representation of cellular interaction, and will compare the behaviour of biological and computational models.