Chapters 2, 7 and 13 are available for download.
Preface
Section 1: Groundwork
1. The Excitement of Developmental Biology
- Where the subject came from
- Central position in biology
- Impact on society
- Future impact
2. Common Features of Development (3mb)
- Genomic equivalence, cloning of animals
- Gametogenesis
- Early development
- Morphogenetic processes
- Growth and death
3. Developmental Genetics
- Developmental mutants
- Screening for mutants
- Cloning of genes
- Transgenesis
- Gene duplication
4. Experimental Embryology
- Normal development
- Developmental commitment
- Acquisition of commitment
- Homeotic genes
- Criteria for proof
5. Techniques for the Study of Development
- Microscopy
- Study of gene expression by biochemical methods
- Study of gene expression by in situ methods
- Reporter genes
- Microinjection
- Cell-labelling methods
- Cell sorting
Section 2: Major model organisms
6. Model Organisms
- The big six
- Availability and cost
- Access and micromanipulation
- Genetics and genome maps
- Relevance and temp
- Oogenesis, maturation, fertilization
- Embryonic development
- Experimental methods
- Regional specification
- Inductive interactions
8. The Zebrafish
- Normal development
- Mutagenesis
- Regional specification
9. The Chick
- Normal development
- Regional specification of the early embryo
- Description of organogenesis in the chick
10. The Mouse
- Mammalian fertilization
- Normal embryonic development
- Technology of mouse development
- Regional specification in development
- Other topics in mouse development
11. Drosophila
- Insects
- Normal development
- Drosophila developmental genetics
- Overview of the developmental program
- The dorsoventral pattern
- The anteroposterior system
12. Caenorhabditis elegans
- Normal development
- Regional specification in the embryo
- Analysis of postembryonic development
- Programmed cell death
Section 3: Organogenesis
13. Tissue Organization and Stem Cells (8mb)
- Types of tissue
- Tissue renewal
- Skin
- Intestine
- Haematopoietic system
14. Development of the Nervous System
- Overall structure and cell types
- Anteroposterior patterning of the neural plate
- Dorsoventral patterning of the neural tube
- Neurogenesis and gliogenesis
- The neural crest
- Development of neuronal connectivity
15. Development of Mesodermal Organs
- Somitogenesis and myogenesis
- The kidney
- Germ cells and gonadal development
- Limb development
- Heart and blood vessels
16. Development of Endodermal Organs
- Normal development
- Determination of the endoderm
- The pancreas
17. Drosophila Imaginal Discs
- Metamorphosis
- Genetic study of larval development
- Mitotic recombination
- Disc development
- Regional patterning of the wing disc
Section 4: Growth, regeneration and evolution
18. Growth, ageing, and cancer
- Size and proportion
- Growth in stature
- Aging
- Postnatal disorders of growth and differentiation
19. Regeneration of Missing Parts
- Distribution of regenerative capacity
- Planarian regeneration
- Vertebrate limb regeneration
20. Evolution and Development
- Macroevolution
- The primordial animal
- What really happened in evolution?
Appendix
Key Molecular Components
- Genes
- Transcription factor families
- Signalling systems
- Inducing factor families
- Cell adhesion molecules
- Extracellular matrix components
