Readme file

SERIES C
Applied Statistics

Flexible estimates of tumour incidence for intermediately lethal tumours in a typical long-term animal bioassay, by H. Parise, G. E. Dinse and L. M. Ryan
Journal of the Royal Statistical Society, Applied Statistics, Sercies C, Volume 50 (2001) part 2, pages 171 - 185

Tetrafluoroethylene is used in the production of polytetrafluoroethylene (Teflon) and other polymers. Tetrafluoroethylene was nominated by the National Cancer Institute for toxicity and carcinogenicity studies based on the potential for human exposure to the chemical due to the large production volume and on the lack of adequate data for tetrafluoroethylene in the literature. Male and female F344/N rats and B6C3F1 mice were exposed to tetrafluoroethylene (98% to 99% pure) by whole body inhalation exposure for 16 days, 13 weeks, or 2 years. Genetic toxicity studies were conducted in mouse peripheral blood erythrocytes.

The file parise.zip contains the data for the 2 year study in the male F344/N rats for leukemias in the control and high dose group. Following is a description of the variables. Variable names appear in the first row.

cid =
 the animal id number,
days =
 the time of death/sacrifice
sex =
 M for male F for female, ONLY males are given here
dose =
 the dose level in ppm
leuk =
 1 if the animal developed leukemia by the time of death and 0 otherwise.

ALSO NOTE: if the animals death time, days, is 733 then the animal was sacrificed.

These data are publically available along with the abstract at the following web site: http://ntp-server.niehs.nih.gov/.

Helen Parise
Statistics and Consulting Unit
Department of Mathematics and Statistics Boston University
111 Cummington Street
Boston
MA 02215
USA

E-mail: hparise@bu.edu

 

Dataset (parise.zip 1.61kb)

 

 Journals

SERIES A
Statistics in Society

SERIES B
Statistical Methodology

SERIES C
Applied Statistics

SERIES D
The Statistician