## The theory of natural selection (part 1) - Can we assess the frequencies of genes or genotypes?

Measuring frequencies of genes and genotypes

Genotype frequency and gene frequency are closely related variables, and both are easy to measure.

Genotype frequency

The simplest case is one genetic locus with two alleles (A and a ) and three genotypes (AA, Aa, and aa ). Each individual has a genotype made up of two genes at the locus and a population can be symbolized like this:

Aa AA aa aa AA Aa AA Aa

This is an imaginary population with only eight individuals. To find the genotype frequencies we simply count the numbers of individual with each genotype. Thus:

frequency of AA = 3/8 = 0.375 frequency of Aa = 3/8 = 0.375 frequency of aa = 2/8 = 0.25

In general we can symbolize genotype frequencies algebraically, as follows.

Genotype AA Aa aa Frequency P Q R

P, Q, and R are expressed as percentages or proportions, so in our population, P = 0.375, Q = 0.375, R = 0.25 (they have to add up to one, or to 100%). They are measured simply by observing and counting the numbers of each type of organism in the population, and dividing by the total number of organisms in the population (the population size).

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