Journal of Neurochemistry Virtual Issues

Journal of Neurochemistry

Published for the International Society for Neurochemistry

• Nicotinic Acetylcholine Receptors, October 2009
• Special issue on cerebral ischemia - pathology and potential countermeasures April 2008
• Special issue on Alzheimer's disease April 2008

TopNicotinic Acetylcholine Receptors, October 2009

Nicotinic acetylcholine receptors (nAChRs) have come of age! The large family of vertebrate and invertebrate subunits gives rise to multiple subtypes of nAChR expressed in neuronal, muscle and many non-excitable tissues. As well as mediating the physiological actions of acetylcholine, nAChRs are implicated in the pathogenesis or treatment of neurodegenerative and neuropsychiatric diseases, they mediate the dependence-producing effects of nicotine that underlie tobacco smoking, and they are targets for neonicotinoid pesticides. The structural heterogeneity and functional diversity of nAChRs has stimulated a raft of research to interrogate these receptors at various levels, from structure-function relationships, to cell signalling and in vivo consequences. This virtual issue of recent nAChR research papers published in the Journal of Neurochemistry reflects the quality and variety of studies emanating form some of the top international laboratories, and includes papers from Australia, China, Europe, South America and the USA.

Nicotine-induced and depolarisation-induced glutamate release from hippocampus mossy fibre synaptosomes: two distinct mechanisms
Victor Bancila, J. Miguel Cordeiro, Alain Bloc, Yves Dunant

Mutations of cytosolic loop residues impair assembly and maturation of α7 nicotinic acetylcholine receptors
Jayanta Mukherjee, Alexander Kuryatov, Stephen J. Moss, Jon M. Lindstrom, Rene Anand

A novel fluorescent α7-conotoxin for the study of α7 nicotinic acetylcholine receptors
Arik J. Hone, Paul Whiteaker, Sean Christensen, Yingxian Xiao, Erin L. Meyer, J. Michael McIntosh

Identification of two Lynx proteins in Nilaparvata lugens and the modulation on insect nicotinic acetylcholine receptors
Zewen Liu, Guangchun Cao, Jian Li, Haibo Bao, Yongjun Zhang

Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeys
Luping Z. Huang, Neeraja Parameswaran, Tanuja Bordia, J. Michael McIntosh, Maryka Quik

Defining pre-synaptic nicotinic receptors regulated by beta amyloid in mouse cortex and hippocampus with receptor null mutants
Tejal K. Mehta, John J. Dougherty, Jianlin Wu, Catherine H. Choi, Ghous M. Khan, Robert A. Nichols

Pre-synaptic nicotinic and D2 receptors functionally interact on dopaminergic nerve endings of rat and mouse nucleus accumbens
Massimo Grilli, Stefania Zappettini, Michele Zoli, Mario Marchi

Role of the N-terminal α-helix in biogenesis of α7 nicotinic receptors
Mar Castillo, José Mulet, Marcos Aldea, Susana Gerber, Salvador Sala, Francisco Sala, Manuel Criado

Role of GSK-3β activation and α7 nAChRs in Aβ1-42-induced tau phosphorylation in PC12 cells
Min Hu, Jeffrey F. Waring, Murali Gopalakrishnan, Jinhe Li

Agonist- and competitive antagonist-induced movement of loop 5 on the α subunit of the neuronal α4β4 nicotinic acetylcholine receptor
Alexandre Mourot, Ernst Bamberg, Jürgen Rettinger

Host-cell specific effects of the nicotinic acetylcholine receptor chaperone RIC-3 revealed by a comparison of human and Drosophila RIC-3 homologues
Stuart J. Lansdell, Toby Collins, Arisa Yabe, Veronica J. Gee, Alasdair J. Gibb, Neil S. Millar

The α4β2α5 nicotinic cholinergic receptor in rat brain is resistant to up-regulation by nicotine in vivo
Danyan Mao, David C. Perry, Robert P. Yasuda, Barry B. Wolfe, Kenneth J. Kellar

NIDA522131, a new radioligand for imaging extrathalamic nicotinic acetylcholine receptors: in vitro and in vivo evaluation
Svetlana I. Chefer, Olga A. Pavlova, Yi Zhang, D. Bruce Vaupel, Alane S. Kimes, Andrew G. Horti, Elliot Stein, Alexey G. Mukhin

Nicotinic α5 subunit deletion locally reduces high-affinity agonist activation without altering nicotinic receptor numbers
Robert W. B. Brown, Allan C. Collins, Jon M. Lindstrom, Paul Whiteaker

Cyclic AMP-dependent protein kinase (PKA) phosphorylates Ser362 and 467 and protein kinase C phosphorylates Ser550 within the M3/M4 cytoplasmic domain of human nicotinic receptor α4 subunits
Veronica V. Pollock, Tina E. Pastoor, Lynn Wecker

Nicotine-induced phosphorylation of ERK in mouse primary cortical neurons: evidence for involvement of glutamatergic signaling and CaMKII
Rebecca C. Steiner, Christopher J. Heath, Marina R. Picciotto

The α1 subunit of nicotinic acetylcholine receptors in the inner ear: transcriptional regulation by ATOH1 and co-expression with the γ subunit in hair cells
Deborah Scheffer, Cyrille Sage, Paola V. Plazas, Mingqian Huang, Carolina Wedemeyer, Duan-Sun Zhang, Zheng-Yi Chen, A. Belen Elgoyhen, David P. Corey, Veronique Pingault

Cholesterol effects on nicotinic acetylcholine receptor
Francisco J. Barrantes

Nicotinic receptor activation by epibatidine induces heme oxygenase-1 and protects chromaffin cells against oxidative stress
Javier Egea, Angelo O. Rosa, Antonio Cuadrado, Antonio G. García, Manuela G. López

Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures
N. Moser, N. Mechawar, I. Jones, A. Gochberg-Sarver, A. Orr-Urtreger, M. Plomann, R. Salas, B. Molles, L. Marubio, U. Roth, U. Maskos, U. Winzer-Serhan, J.-P. Bourgeois, A.-M. Le Sourd, M. De Biasi, H. Schröder, J. Lindstrom, A. Maelicke, J.-P. Changeux, A. Wevers

The β-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the α7 nicotinic acetylcholine receptor
David H. Small, Danuta Maksel, Megan L. Kerr, Judy Ng, Xu Hou, Cindy Chu, Hossein Mehrani, Sharon Unabia, Michael F. Azari, Richard Loiacono, Marie-Isabel Aguilar, Mary Chebib

The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery
Roger L. Papke, Linda P. Dwoskin, Peter A. Crooks

Differential coupling of α7 and non-α7 nicotinic acetylcholine receptors to calcium-induced calcium release and voltage-operated calcium channels in PC12 cells
Jane A. Dickinson, Katharine E. Hanrott, M. H. Selina Mok, James N. C. Kew, Susan Wonnacott

TopSpecial issue on cerebral ischemia - pathology and potential countermeasures April 2008

Edited by Sean Murphy

Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation
Jyh-Fei Liao, Yuh-Chiang Shen, Yea-Hwey Wang, Yueh-Ching Chou, Kuo-Tong Liou, Jin-Cherng Yen, Wen-Yen Wang

Superoxide dismutase/catalase mimetics but not MAP kinase inhibitors are neuroprotective against oxygen/glucose deprivation-induced neuronal death in hippocampus
Miou Zhou, eymundo Dominguez, Michel Baudry

Role of K_ATP channels in protection against neuronal excitatory insults
Youming Lu, Mangala Soundarapandian, Xiaofen Zhong, Lisheng Peng, Di Wu

Reduced neuronal nitric oxide synthase is involved in ischemia-induced hippocampal neurogenesis by up-regulating inducible nitric oxide synthase expression
Chun-Xia Luo, Xin-Jian Zhu, Qi-Gang Zhou, Bin Wang, Wei Wang, Hui-Hui Cai, Yong-Jun Sun, Mei Hu, Jun Jiang, Yao Hua, Xiao Han, Dong Ya Zhu

Changes in brain levels of N-acylethanolamines and 2-arachidonoylglycerol in focal cerebral ischemia in mice
Matilda Degn, Kate Lambertsen, Gitte Petersen, Michael Meldgaard, Andreas Artmann, Bettina Clausen, Steen Hansen, Bente Finsen, Harald Hansen, Trine Lund

NO-induced neuroprotection in ischemic preconditioning stimulates mitochondrial Mn-SOD activity and expression via RAS/ERK1/2 pathway
A. Scorziello , M. Santillo , A. Adornetto , C. Dell’Aversano , R. Sirabella , S. Damiano , L.M.T. Canzoniero , G.F. Di Renzo , Lucio Annunziato

Cell death in an ischemic infarct rim model
Hang Yao, Xiaolu Sun, Xiang Gu, Juan Wang, Gabriel Haddad

Neuroprotection and stroke: time for a compromise
Alan Young, Carine Ali, Arnaud Duretete, Denis Vivien

High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo
G Faraco, S Fossati, M Bianchi, M Patrone, M Pedrazzi, B Sparatore, F Moroni, Alberto Chiarugi

Nitric oxide from neuronal nitric oxide synthase sensitises neurons to hypoxia-induced death via competitive inhibition of cytochrome oxidase
Aiste Jekabsone, Jonas Neher, Vilmante Borutaite, Guy Brown

Central nervous system regulation of mammalian hibernation: implications for metabolic suppression and ischemia tolerance
Kelly Drew, C. Loren Buck, Brian Barnes, Sherri Christian, Brian Rasley, Michael Harris

Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1α and apoptotic genes in a middle cerebral artery occlusion-induced focal ischemia rat model
Chunhua Chen, Qin Hu, Junhao Yan, Jiliang Lei, Lihua Qin, Xianzhong Shi, Liju Luan, Lei Yang, Ke Want, Jingyan Han, Anil Nanda, Changman Zhou

Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism
Kazuhide Hayakawa, Kenichi Mishima, Masanori Nozako, Mai Hazekawa, Keiichi Irie, Masayuki Fujioka, Kensuke Orito, Kohji Abe, Nobuyoshi Hasebe, Nobuaki Egashira, Katunori Iwasaki, Michihiro Fujiwara

Constitutively active calcineurin mediates delayed neuronal death through Fas-ligand expression via activation of NFAT and FKHR transcriptional activities in mouse brain ischemia
Norifumi Shioda, Feng Han, Shigeki Moriguchi, Kohji Fukunaga

Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia
Mushfiquddin Khan, Chinnasamy Elango, Mubeen Ansari, Avtar Singh, Inderjit Singh

Inhibition of the myosin light chain kinase prevents hypoxia-induced blood–brain barrier disruption
Christoph Kuhlmann, Ryo Tamaki, Martin Gamerdinger, Volkmar Lessmann, Christian Behl, Oliver Kempski, Heiko Luhmann

Neuroprotective actions of a histidine analogue in models of ischemic stroke
Sung-Chun Tang, Thiruma Arumugam, Roy Cutler, Dong-Gyu Jo, Tim Magnus, Sic Chan, Mohamed Mughal, Richard Telljohann, Matthew Nassar, Xin Ouyang, Andrea Calderan, Paolo Ruzza, Andrea Guiotto, Mark Mattson

Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein
Leslie Johnson-Anuna, Gunter Eckert, Cornelia Franke, Urule Igbavboa, Walter Müller, W. Gibson Wood

Factors influencing cell fate in the infarct rim
Hang Yao, Yousheng Shu, Juan Wang, Brendan Brinkman, Gabriel Haddad

Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood–brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats
Eduardo Candelario-Jalil, Armando González-Falcón , Michel García-Cabrera, Olga Sonia León , Bernd Fiebich

TopSpecial issue on Alzheimer's disease April 2008

Cerebral clearance of human amyloid-β peptide (1–40) across the blood–brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes
Shingo Ito, Sumio Ohtsuki, Junichi Kamiie, Yasuko Nezu, Tetsuya Terasaki

Important differences between human and mouse APOE gene promoters: limitation of mouse APOE model in studying Alzheimer's disease
Bryan Maloney, Yuan-Wen Ge, George Alley, Debomoy Lahiri

Single molecule profiling of tau gene expression in Alzheimer's disease
Chris Conrad, Jun Zhu, Cintia Conrad, David Schoenfeld, Zhide Fang, Martin Ingelsson, Stefan Stamm, George Church, Bradley Hyman

GABA_A receptors in aging and Alzheimer's disease
Robert Rissman, Angel DeBlas, David Armstrong

Intraneuronal amyloid-β plays a role in mediating the synergistic pathological effects of apoE4 and environmental stimulation
Ofir Levi, Iftach Dolev, Haim Belinson, Daniel Michaelson

Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo
Sam Gandy, Yun-wu Zhang, Annat Ikin, Stephen Schmidt, Efrat Levy, Roxanne Sheffield, Ralph Nixon, Francesca-Fang Lio, Paul Matthews, Huaxi Xu, Michelle Ehrlich

Sensitive ELISA detection of amyloid-β protofibrils in biological samples
Hillevi Englund, Dag Sehlin, Ann-Sofi Johansson, Lars Nilsson, Pär Gellerfors, Staffan Paulie, Lars Lannfelt, Frida Ekholm Pettersson

In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques
Joseph Poduslo, Muthu Ramakrishnan, Marina Ramirez-Alvarado, Karunya Kandimalla, Emily Gilles, Geoffry Curran, Thomas Wengenack

High intracellular concentrations of amyloid-beta block nuclear translocation of phosphorylated CREB
D Arvanitis, A Ducatenzeiler, J Ou, E Grodstein, S Andrews, S Tendulkar, A Ribeiro-da-Silva, M Szyf, A Cuello

Oxysterols, cholesterol homeostasis, and Alzheimer disease
Jacob Vaya, Hyman Schipper

Enhancement of α-secretase cleavage of amyloid precursor protein by a metalloendopeptidase nardilysin
Yoshinori Hiraoka, Mikiko Phno, Kazuhiro Yoshida, Katsuya Okawa, Hidekazu Tomimoto, Toru Kita, Eiichirio Nichi

Inhibition of amyloid β-peptide production by blockage of β-secretase cleavage site of amyloid precursor protein
Chan Na, Sang Jeon, Guangtao Zhang, Gary Olson, Chi-Bom Chae

Folate deprivation increases presenilin expression, gamma-secretase activity, and Abeta levels in murine brain: potentiation by ApoE deficiency and alleviation by dietary S-adenosyl methionine
Amy Chan, Thomas Shea

Genetically augmenting tau levels does not modulate the onset or progression of Aβ pathology in transgenic mice
Salvatore Oddo, Antonella Caccamo, David Cheng, Bahareh Jouleh, Reidun Torp, Frank LaFerla

Elevated plasma cholesterol does not affect brain Aβ in mice lacking the low-density lipoprotein receptor
Gregory Elder, Julie Cho, Daniel English, Sonia Franciosi, James Schmeidler, Miguel Gama Sosa, Rita De Gasperi, Edward Fisher, Paul Matthews, Vahram Haroutunian, Joseph Buxbaum

The Arctic Alzheimer mutation favors intracellular amyloid-β production by making amyloid precursor protein less available to α-secretase
Charlotte Sahlin, Anna Lord, Kristina Magnusson, Hillevi Englund, Claudia Almedia, Paul Greengard, Fred Nyberg, Gunnar Gouras, Lars Lannfelt, Nilsson

Effects of the monomeric, oligomeric, and fibrillar Aβ₄₂ peptides on the proliferation and differentiation of adult neural stem cells from subventricular zone
Chaejeong Heo, Keun-A Chang, Hee Soon Choi, Hye-Sun Kim, Seonghan Kim, Hyunjeong Liew, Jeong a Kim, Eunah Yu, Jie Ma, Yoo-Hun Suh

Inverse and distinct modulation of tau-dependent neurodegeneration by presenilin 1 and amyloid-β in cultured cortical neurons: evidence that tau phosphorylation is the limiting factor in amyloid-β-induced cell death
Juila Leschik, Alfred Welzel, Carina Weissmann, Anne Eckert, Roland Brandt

Aβ Oligomers – a decade of discovery
Dominic Walsh, Dennis Selkoe

The β-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the α7 nicotinic acetylcholine receptor
David. H Small, Danuta Maksel, Megan Kerr, Judy Ng, Xu Hou, Cindy Chu, Hossein Mehrani, Sharon Unabia, Michael Azari, Richard Loiacono, Marie Isabel Aguilar, Mary Chebib

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases β-cleavage of amyloid precursor protein and amyloid-β production in vivo
Ishrut Hussain, Julie Hawkins, David Harrison, Christopher Hille, Gareth Wayne, Leanne Cutler, Tania Buck, Daryl Walter, Emmanuel Demont, Colin Howes, Alan Naylor, Philip Jeffrey, Maria Gonzalez, Colin Dingwall, Anton Michel, Sally Redshaw, John Davis

Acyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-β peptide
Rina Yamin, Sandipan Bagchi, Rick Hildebrant, Andrea Scaloni, Russell Widom, Carmela Abraham

Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator–monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease¹
Yael Avramovich-Tirosh, Tamar Amit, Orit Bar-Am, Hailin Zheng, Mati Fridkin, Moussa Youdim

Novel modulators of amyloid-β precursor protein processing
Bor Luen Tang, Yih Cherng Liou

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