Congress of the International Society on Thrombosis and Haemostasis

Outcome of catheter-related arterial thrombosis in children

Abstract number: PP-TH-446

Kroiss¹ S., Kretschmar² O., Forster³ I., Schmugge¹ M., Albisetti¹ M.

¹¹Hematology ²²Cardiology ³³Radiology, University Children Hospital, Zurich, Switzerland

How-to-cite Kroiss S, Kretschmar O, Forster I, Schmugge M, Albisetti M. Outcome of catheter-related arterial thrombosis in children. Journal of Thrombosis and Haemostasis 2009; Volume 7, Supplement 2: Abstract PP-TH-446

Introduction: Catheter-related arterial thrombosis (CAT) is increasingly recognized in children requiring cardiac surgery or catheterization. The long-term outcome of these thrombotic complications is not known.

Methods: Children with congenital heart disease treated for CAT between 2002 and 2007 were investigated. Follow-up examinations consisted of Doppler-ultrasonography (US), and measurements of blood pressure and of both leg length and circumference.

Results: The follow-up of 68 cases of CAT in a total of 61 children (median age 35 days) is presented. CAT was related to indwelling arterial catheters in 42% and cardiac catheterization in 58%, and located in the inguinal arteries in all cases. Initial treatment of CAT consisted of heparin in 64, and acetylsalicylic acid in 4 of the 68 cases. Follow-up was performed at a median of 20 months (range: 1 month-5.6 years) after CAT diagnosis. On US, complete resolution of CAT was observed in 47 (69%), no resolution in 18 (26.5%), and partial resolution in 3 (4.5%) of the 68 cases. Difference in blood pressure of more than 15 mmHg was present in 15 (24.5%) of the 61 children, 10 of them showing no or only partial resolution of CAT. Difference in leg length and/or circumference of more than 1 cm was present in 15 (24.5%) of the 61 children, 6 of them showing no or only partial resolution of CAT. In 1 child, claudication was present.

Conclusions: CAT in children with congenital heart disease is possibly associated with long-term morbidity including difference in blood pressure, disturbances of leg growth, and claudication. Moreover, persistent vascular occlusion in 1/3 of children may limit easy vascular access for future interventions. Studies on optimal therapy of CAT in children are required.

Disclosure of interest: none declared.

To cite this abstract use the following format:

Journal of Thrombosis and Haemostasis 2007; Volume 5, Supplement 2: abstract number

Session Details

Date:	Unpresented
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Session name:	ISTH2009
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